Can we play Lego using proteins? Oh yeah! With some help from machine learning 🧪🧬🖥️ Read how here! plentyofroom.beehiiv.com/p/ai-designe...

Can you use DNA traps to fight tumors? This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬 Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪 More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎 Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

400 million tonnes of plastic are produced each year, with tons of environmental problems. Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬 PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...

Turning plastic waste into paracetamol, using bacteria? 😲 Is there something more sci-fi? 🧪 But yeah, now it's possible! Read all about it here 👉👉 plentyofroom.beehiiv.com/p/synbio-bre...

Is AI joining the CRISPR chat? CRISPR-GPT is a new AI-collaboration tool created to make the design of gene editing experiments as easy as possible! Is this the future of science? 🤔🧪 Subscribe to get more like this plentyofroom.beehiiv.com/p/ai-joins-t...

What do emus (yeah, the bird!) and protein dynamics have in common? 🧪 More than you would expect! Don't miss this cool work at the interface of AI and protein structures 😎 Read and subscribe 👉 plentyofroom.beehiiv.com/p/ai-powered...

Light up the membrane! 💡🧪🧬🖥️ Transmembrane proteins are membrane gatekeepers, but designing new functional ones is hard. This paper applies the power of ML to create transmembrane proteins that can bind small molecules and fluoresce 🏮 Read and subscribe! 👉 plentyofroom.beehiiv.com/p/ai-designe...

1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said." It's literally a vital feature of both science and of representative democracy. I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.

Emus and protein science? Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬 BioEmu uses machine learning to emulate protein dynamics with high precision and speed! It complements simulations: first test with BioEmu, then continue with MD. Read and subscribe tinyurl.com/enf5apzc

Is there something cooler than structural biology papers? 🧪🖥️🧬 Looking at RNA structures, of course! 😎 Do we know what these RNA nanocages do? No. Are they cool? Yes. Did they try to use them for drug delivery? Also yes. Subscribe and get more like this at plentyofroom.beehiiv.com/p/rna-nanoca...

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable". But today a new method creates binders using the power of computational methods! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

New issue is here 🎉 Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable". But today a new method creates binders using the power of computational methods! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

Do you want to save your data in DNA? Well, now is coming closer! This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️ Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...

Is it possible to leverage AI to create functional RNAs? Well, from now yes! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

Just in case you missed this super cool paper 😎🧪

Bacteria turning plastic into drugs? Oh yeah! Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬 Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre... #chemistry

Gene editing is moving from the lab to the clinic, but delivering gene-sized DNA is still a problem. Today's paper evolved new CRISPR-associated transposons using phage-assisted evolution! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/gene-editi... #biotech #genomeediting

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪 Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML #Ai

Don't miss this cool work! 🧪

Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine! 🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social Want more like this? 👉 tinyurl.com/2da2k8dy #biotech #ML #AI 🧬🖥️

Nothing to read on Sunday? I got you covered! What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪 Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML #Ai

Protein design and regenerative medicine: is this the coolest duo? Today, the authors used computationally designed proteins to guide tissue regeneration! Amazing work from @uwproteindesign.bsky.social and @upc.edu! 🧪🖥️🧬 Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML #Ai

Do you need something to fill the void until the next issue? 😎 Well, last week's is just here! 🧪 plentyofroom.beehiiv.com/p/gene-editi...

Very cool research! 🧪

Bacteria transforming plastics into paracetamol, insane! In all the good ways 🧪 www.nature.com/articles/s41...

Protein sequencing is never easy, but it’s especially hard when there’s no database to help. But that’s exactly the case in many exciting areas of research: microbiomes, venom studies, immunopeptidomics, or synthetic proteins! 🧪

Gene editing is finally stepping out of the lab and into the clinic. There are over 60 trials underway, with base editors, prime editors, and programmable nucleases all available. 🧪

Gene editing is moving from the lab to the clinic, but delivering gene-sized DNA is a still a problem. Today's paper evolved new CRISPR-associate transposons using phage-assisted evolution! 🧪🖥️🧬

𝐑𝐚𝐩𝐢𝐝 𝐭𝐞𝐬𝐭𝐬 are fast, cheap, and convenient. They are everywhere, from COVID swabs to pregnancy tests. But they have a problem: low sensitivity. Rapid tests struggle to detect low levels of important biomarkers, which is fundamental for early disease diagnosis! 🧪

DNA origami dominates DNA nanotech. But what if we could build 𝑤𝑖𝑡ℎ𝑜𝑢𝑡 the scaffold? 🧬🧪 Today’s paper introduces 𝐁𝐑𝐀𝐈𝐃𝐒: the first automated pipeline for designing 𝐬𝐜𝐚𝐟𝐟𝐨𝐥𝐝-𝐟𝐫𝐞𝐞 𝐃𝐍𝐀 𝐰𝐢𝐫𝐞𝐟𝐫𝐚𝐦𝐞 structures.

Looking for something fresh on these summer days? This is what you're looking for 😎🧪

It's time for alternatives to DNA origami! Enter BRAIDS, an automated pipeline to create scaffold-free wireframe DNA structures. Scaling to over 30.000 nt, this is a great tool for DNA nanostructures! 🧬🖥️🧪 Subscribe to get more plentyofroom.beehiiv.com/p/dna-wirefr... #nanotech #biotech

Today, a great paper tackling a giant challenge: antibiotic resistance! A new type of antibiotics from @mcmasteruniversity.bsky.social and University of Illinois Chicago 🧪 😎 #drugs #drugresistance #biotech Get more like this at 👉 plentyofroom.beehiiv.com/p/lasso-pept...

Can we build cytoskeletons 𝑤𝑖𝑡ℎ𝑜𝑢𝑡 proteins? A new paper shows we might, using 𝐑𝐍𝐀 𝐨𝐫𝐢𝐠𝐚𝐦𝐢! 🧬🧪

Don't miss this one! 🧪

30% of proteins and 50% of target drugs are membrane proteins. And yet, their production is still hard! A great article from @ucdavis.bsky.social merges cell-free systems, robotics and machine learning to improve this! Subscribe to get more like this 🧪🧬🖥️ #biotech #machinelearning #robotics

Amazing work on creating new enzymes! 🧪Subscribe to get more like this in your inbox! plentyofroom.beehiiv.com/p/ai-designe... #science #AI

Such a cool paper! 🧪

Amazing work! Don't miss it 🧪

Proteins are dynamic machines. Subtle changes, a loop shifts, a helix wiggles, and a protein turns on or off. These movements drive signaling, catalysis and protein regulations: including many key drug targets! 🧪

Last week AI designed RNA, today it creates dynamic proteins! Small movements have a big impact in proteins, but it has been hard to replicate: until now! Great work from @ucsanfrancisco.bsky.social Subscribe to get more 👉 plentyofroom.beehiiv.com/p/ai-protein... 🧪🧬🖥️ #biotech #AI #deeplearning

Is it possible to leverage AI to create functional RNAs? Well, from now yes! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

Can CRISPR delivery get boosted? Delivery is still one of the big bottlenecks for clinical gene editing. There are a lot of options, with viral vectors, lipid nanoparticles, DNA nanostructures, VLPs, but none of them quite check all the boxes. 🧪

Wow so cool! 🧪

Searching for a weekend read? I got you! Is it possible to leverage AI to create functional RNAs? Well, from now yes! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

Thursday means just one thing: new issue! AI has shown great potential for protein design (looking at you, Alphafold). But is it possible to leverage it to create functional RNA? Well, from now yes! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

Waiting for tomorrow's issue? 😎 Check out last week's! This paper mixes DNA origami with high-resolution microscopy to create nanopatterned functional surfaces! 🧪 Subscribe to get more like this! 👉 plentyofroom.beehiiv.com/p/nanoscale-... #DNA #nanotech #lithograpy #printing

This seems worth reading! 🧪

With all the great news about gene editing, it's time to re-read this one! 🧪 CRISPR delivery is a problem: ENVLPE solves it! Amazing work from @tum.de and @www.helmholtz-munich.de Read everything and subscribe at 👉 plentyofroom.beehiiv.com/p/crispr-del... #geneediting #biotech #CRISPR