Summary: arguing that cell-intrinsic encoding of antigen-agnostic memory will strictly limit its durability, we propose a cell-extrinsic mechanism wherein the memory durability is no longer constrained by per-cell dynamics, tuned instead by the overall immune circuit dynamics.

Excited to share our preprint on the dynamics of antigen-agnostic immune memory! www.biorxiv.org/content/10.1...

Excited to have this Opinion out! We propose that the diverse functions of Treg cells in health and disease may be interpreted in terms of different dynamical regimes of an immune cell circuit, which provides a powerful framework for analyzing experimental data. www.sciencedirect.com/science/arti...