Newton (@cp-newton.bsky.social)

Emerging optical imaging of three-dimensional cellular-scale mechanics in mechanobiology Mechanobiology is unveiling how forces and mechanical properties influence cell function, development, and disease. A key challenge in this area has been measuring cellular mechanics in situ, within living tissues. This perspective highlights recent advances in optical imaging, particularly Brillouin microscopy and optical coherence elastography, which now enable non-invasive, high-resolution mechanical measurements in three dimensions. We critically assess the strengths, limitations, and future potential of these methods in the context of the next generation of discoveries in mechanobiology. http://dlvr.it/TNNMSn