(@lupold-lab.bsky.social)

We’re pleased to share our new bioRxiv study: Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor. Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME. www.biorxiv.org/content/10.1... #miRNA #ProstateCancer #scRNAseq

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Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer Aberrant microRNA expression is common in cancer, yet cell-type-specific microRNA activity in the tumor microenvironment (TME) remains poorly understood. Here, we show that germline deletion of miR-21... https://www.biorxiv.org/content/10.1101/2025.05.14.654101v1