Our work expanding the Large Serine Integrase toolkit is finally out! We used alphafold-multimer to identify likely recombination directionality factors and tested them experimentally. Much credit to fantastic postdoc Heewhan Shin. @heewhanshin.bsky.social‬ #Alphafold #MobileGeneticElements

Finally posted - our structures that explain directionality control in large serine integrases! Read all about how these amazingly clever molecular swivels are controlled: www.biorxiv.org/content/10.1... Much hard work by postdoc Heewhan Shin and many thanks to collaborator Femi Olorunniji.