Loss of E3 ligase Ube4A disrupts colon homeostasis and accelerates experimental colitis via altered lipid handling https://www.biorxiv.org/content/10.64898/2026.01.02.697430v1

Oral Administration of the carboxylic acid ester prodrug NHC SN_9 protects mice from lethal Orthopoxvirus challenge: Implications for the Treatment of Monkeypox https://www.biorxiv.org/content/10.64898/2025.12.30.696971v1

Endothelial TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis https://www.biorxiv.org/content/10.64898/2025.12.31.697193v1

High-Throughput, Multiplex Immunofluorescence for the Computer-automated Immunophenotyping of Mycosis Fungoides https://www.biorxiv.org/content/10.64898/2025.12.30.697118v1

TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Fibrosis in Obstructive Kidney Injury https://www.biorxiv.org/content/10.64898/2025.12.30.697039v1

Isoflavone treatment attenuates cardiovascular-kidney-metabolic (CKM) syndrome symptoms in an experimental model of ovariectomized rats. https://www.biorxiv.org/content/10.64898/2025.12.23.696268v1

Morphometry-based detection of deep learning faults in glomerular segmentation https://www.biorxiv.org/content/10.64898/2025.12.23.696291v1

Cell-based calcification assays - magnesium overrules calcium phosphate saturation in overall outcome https://www.biorxiv.org/content/10.64898/2025.12.23.696208v1

Preclinical characterization of AT-03, a novel Serum Amyloid P fusion protein that demonstrates pan-amyloid binding and removal https://www.biorxiv.org/content/10.64898/2025.12.23.696051v1

LARP6 Promotes Features of Plaque Stability and Smooth Muscle Cell Survival in Atherosclerosis https://www.biorxiv.org/content/10.64898/2025.12.22.696106v1

Biologically-Inspired Digital Histology for Deep Phenotyping of Placental Composition Changes Across Major Lesion Types https://www.biorxiv.org/content/10.64898/2025.12.22.693945v1

Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance https://www.biorxiv.org/content/10.64898/2025.12.19.694840v1

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types https://www.biorxiv.org/content/10.64898/2025.12.19.695600v1

Correlative Ultrastructural Mapping of Lewy Pathology Reveals Regional Diversity in Parkinsons and Dementia with Lewy bodies https://www.biorxiv.org/content/10.64898/2025.12.19.695426v1

Accelerated Apolipoprotein A-II senile amyloidosis in a PAI-1 (plasminogen activator inhibitor 1) knock-out model https://www.biorxiv.org/content/10.64898/2025.12.18.695159v1

Human liver organoids uncover ductular reaction in Wolman disease and inform gene therapy design https://www.biorxiv.org/content/10.64898/2025.12.16.694623v1

Reinke crystals are immunoreactive for purine-synthesizing metabolic enzymes https://www.biorxiv.org/content/10.64898/2025.12.18.695235v1

Pyruvate promotes ciliogenesis bypassing IFT88 dependency and attenuates DSS-induced colitis https://www.biorxiv.org/content/10.64898/2025.12.17.694572v1

Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease. https://www.biorxiv.org/content/10.64898/2025.12.15.694523v1

SMOC1 Regulates Endothelial-to-Mesenchymal Transition During Cardiac Repair After Myocardial Infarction https://www.biorxiv.org/content/10.64898/2025.12.10.693412v1

Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease https://www.biorxiv.org/content/10.64898/2025.12.08.693036v1

Sequential mitochondrial remodeling in cardiomyocytes drives diastolic dysfunction and transition to HFrEF in anthracycline-induced cardiotoxicity https://www.biorxiv.org/content/10.64898/2025.12.05.692508v1

Early blood-spinal cord barrier stabilization preserves peri-lesional tissue and improves recovery after SCI https://www.biorxiv.org/content/10.64898/2025.12.03.692136v1

Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathy https://www.biorxiv.org/content/10.64898/2025.12.03.692123v1

Female-predominant anti-CD4 IgG autoantibody production and its correlations with plasma levels of progesterone, microbial translocation, and blunted immune reconstitution in HIV-infected patients on suppressive ART https://www.biorxiv.org/content/10.64898/2025.12.03.689730v1

Sexually Dimorphic Transdifferentiation of Endothelial Cells in Atherosclerosis https://www.biorxiv.org/content/10.64898/2025.12.01.691732v1

TWEAK and Fn14 expression in osteoarthritis: evidence for TWEAK-induced RANKL release from chondrocytes https://www.biorxiv.org/content/10.64898/2025.11.30.691475v1

Resolution of the circulating pathogenic phenotype of alpha-1 antitrypsin deficiency following liver transplantation https://www.biorxiv.org/content/10.64898/2025.11.29.691315v1

Angiotensin II Induces Abdominal Aortic Branch Aneurysms in Fibrillin-1C1041G/+ Mice https://www.biorxiv.org/content/10.1101/2025.11.26.690689v1

Anatomical Research on the Anterior Cruciate Ligament of the Knee https://www.biorxiv.org/content/10.1101/2025.11.23.690033v1

Digital Spatial Pathway Mapping Reveals Prognostic Tumor States in Head and Neck Cancer https://www.biorxiv.org/content/10.1101/2025.11.24.689710v1

Exhaled breath condensate proteomics using amphipols improves protein detection but reveals statistical challenges in respiratory disease biomarker discovery https://www.biorxiv.org/content/10.1101/2025.11.21.689702v1

Glutamine alters the response to stress in mice with diet-induced obesity in a sex-dependent manner. https://www.biorxiv.org/content/10.1101/2025.11.21.689652v1

Circadian clock regulates epidermal endocrine system in homeostatic skin pigmentation https://www.biorxiv.org/content/10.1101/2025.11.20.689605v1

EPHB2 promotes diet-induced MASH liver fibrosis https://www.biorxiv.org/content/10.1101/2025.11.19.688968v1

Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis inPlasminogen Activator Inhibitor-1 Deficient Mice https://www.biorxiv.org/content/10.1101/2025.11.19.689269v1

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis https://www.biorxiv.org/content/10.1101/2025.11.18.689117v1

INVA8001, a Novel and Highly Selective Chymase Inhibitor, Ameliorates Liver Inflammation, Fibrosis, and Hyperplasia in Mdr2 Knockout Mice https://www.biorxiv.org/content/10.1101/2025.11.18.688305v1

RUNX2 promotes epigenetic WNT signaling in inflamed intestinal epithelial cells https://www.biorxiv.org/content/10.1101/2025.11.17.688458v1

SAMP1/TMEM201 Promotes Hepatic Gluconeogenesis by PKA/CREB Pathway https://www.biorxiv.org/content/10.1101/2025.11.17.688768v1

Adipocyte IL-22RA1 signaling promotes structural and functional remodeling of white adipose tissue following acute intestinal damage. https://www.biorxiv.org/content/10.1101/2025.11.14.688505v1

Integrated Bioinformatics analysis and Metabolomic Responses in finding novel therapeutic approach to treat viral myocarditis https://www.biorxiv.org/content/10.1101/2025.11.13.688209v1

The role of muscle fascia in heterotopic ossification and maintenance of skeletal muscle integrity in fibrodysplasia ossificans progressiva https://www.biorxiv.org/content/10.1101/2025.11.12.688008v1

An aerosolised dual-action Autotaxin inhibitor- PPARγ agonist for the treatment of pulmonary fibrosis https://www.biorxiv.org/content/10.1101/2025.11.12.687859v1

Fosl2 regulates the transition from parietal epithelial cells to myofibroblasts in the kidney https://www.biorxiv.org/content/10.1101/2025.11.10.687667v1

Image Analysis for Non-Neoplastic Kidney Disease: Utilizing Morphological Segmentation to Improve Quantification of Interstitial Fibrosis https://www.biorxiv.org/content/10.1101/2025.11.10.686700v1

Detection of a novel Puccinia coronata f. sp. avenae genotypic lineage in Australia during the 2024 oat growing season https://www.biorxiv.org/content/10.1101/2025.11.08.687394v1

Risk Factors and Patterns of Treponema Infection Affecting Olive Baboons in Gombe National Park https://www.biorxiv.org/content/10.1101/2025.11.07.687138v1

Automated spermatogenic staging in PAS-stained testes of Sprague-Dawley rats using a deep learning model for nomal and atrophied tissues https://www.biorxiv.org/content/10.1101/2025.11.06.687107v1

Synergistic therapeutic effects of endolysin BNT331 and a Lactobacillus crispatus consortium in a human vagina chip model of bacterial vaginosis https://www.biorxiv.org/content/10.1101/2025.11.05.686849v1