Late-Talking Children Talk More? A Machine Learning Approach to Speech Act Analysis in Early Childhood https://www.biorxiv.org/content/10.1101/2025.09.30.679667v1

Development of a High-Throughput Screening Method for Anti-NNV Drugs https://www.biorxiv.org/content/10.1101/2025.09.30.679469v1

ATG4D loss leads to late-onset cardiomyopathy and stress-induced heart failure in mice, and its repression marks maladaptive cardiac remodeling in humans https://www.biorxiv.org/content/10.1101/2025.09.29.678527v1

BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy https://www.biorxiv.org/content/10.1101/2025.09.26.678914v1

Deletion of Cd248 in Postn positive myofibroblast Fails to Attenuate Cardiac Remodeling and Fibrosis in a Murine Model of Pressure-Overload Cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.09.26.678917v1

Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD https://www.biorxiv.org/content/10.1101/2025.09.26.678483v1

Phenomenological model of transthyretin stabilization https://www.biorxiv.org/content/10.1101/2025.09.25.678455v1

The fate of melanocytes and the disorganization of basement membrane in a guinea pig model of Rhododendrol-induced chemical vitiligo https://www.biorxiv.org/content/10.1101/2025.09.24.678429v1

N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation https://www.biorxiv.org/content/10.1101/2025.09.24.678188v1

Lzp Ablation Ameliorates Dyslipidemia and Suppresses Atherosclerosis by Reducing Circulating Apolipoprotein B-Containing Lipoproteins https://www.biorxiv.org/content/10.1101/2025.09.24.678175v1

TLR4 promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis by a mechanism independent of hepatocytes and inflammatory cells https://www.biorxiv.org/content/10.1101/2025.09.25.678670v1

Repurpose of Ritlecitinib Reduces Neointima Formation and Enhances Endothelial Recovery Following Vascular Injury https://www.biorxiv.org/content/10.1101/2025.09.23.678172v1

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease https://www.biorxiv.org/content/10.1101/2025.09.22.677648v1

Alkalinized Filtered Water Induces Changes in the Gut Microbiome in Inflammatory Bowel Disease. https://www.biorxiv.org/content/10.1101/2025.09.19.677298v1

Probing the activity of cysteine cathepsins in inflammatory bowel diseases https://www.biorxiv.org/content/10.1101/2025.09.18.677249v1

Hepatitis E ORF2 blocks trophoblast autophagy to induce miscarriage via LC3B binding rather than PI3K/Akt/mTOR pathway suppression https://www.biorxiv.org/content/10.1101/2025.09.19.677307v1

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma https://www.biorxiv.org/content/10.1101/2025.09.19.677076v1

Intermittent Hypoxia Drives Early Metabolic Dysfunction in Brown Adipose Tissue https://www.biorxiv.org/content/10.1101/2025.09.18.676807v1

Interpretable Deep Learning Reveals Biologically Relevant Spatial Gene Expression Patterns in Lung Tumors and their Microenvironment https://www.biorxiv.org/content/10.1101/2025.09.17.674367v1

Mitochondrial stress in Fabry disease https://www.biorxiv.org/content/10.1101/2025.09.16.676526v1

Sex differences in alpha galactosidase protein processing and its impact on disease severity in Fabry disease https://www.biorxiv.org/content/10.1101/2025.09.16.676554v1

The Impact of Formic Acid Treatment on Brain Tissues for Prion Inactivation https://www.biorxiv.org/content/10.1101/2025.09.16.676643v1

Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association https://www.biorxiv.org/content/10.1101/2025.09.15.676282v1

Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn's Disease: Repurposing Cancer drugs for Permeability Barrier Healing. https://www.biorxiv.org/content/10.1101/2025.09.16.676680v1

Embryonic Atrial Injury Programs an Anti-Fibrotic Atrial Fibrillation Substrate https://www.biorxiv.org/content/10.1101/2025.09.16.676656v1

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes https://www.biorxiv.org/content/10.1101/2025.09.13.676053v1

Track to Combat Wheat Stem Rust (Puccinia graminis f. sp. tritici) Races: Pathogenicity Spectrum, Tempo-Spatial Dynamics, and Impacts on Irrigated Wheat in Ethiopia under Climate Change https://www.biorxiv.org/content/10.1101/2025.09.14.676115v1

TSPO deficiency reveals a novel role for porphyrins in regulating white adipose tissue lipid metabolism https://www.biorxiv.org/content/10.1101/2025.09.14.676078v1

Understanding Foundation Models in Digital Pathology: Performance, Trade-offs, and Model-Selection Recommendations https://www.biorxiv.org/content/10.1101/2025.09.12.675923v1

Aortic Valve Remodeling in Chronic Kidney Disease: A Mineralocorticoid Receptor-Driven Mechanism Involving NGAL and TLR4 Pathways https://www.biorxiv.org/content/10.1101/2025.09.12.675970v1

An automated morphometric approach to evaluate distal lung patterning in mouse models of Bronchopulmonary Dysplasia https://www.biorxiv.org/content/10.1101/2025.09.11.675692v1

Novel Biomaterial-Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis-Driven Osteoarthritis https://www.biorxiv.org/content/10.1101/2025.09.11.675532v1

Impact of the maternal environment on cardiovascular features of the offspring in a mouse model of Marfan syndrome https://www.biorxiv.org/content/10.1101/2025.09.10.675335v1

Pathological Angiogenesis Precedes the Onset of Aortic Dissection https://www.biorxiv.org/content/10.1101/2025.09.10.675317v1

PDLIM2 Repression: A Common Mechanism in Viral Lung Infection https://www.biorxiv.org/content/10.1101/2025.09.12.675949v1

Pre- and postnatal 1,4-phenylene di-isothiocyanate treatment does not induce bile duct injury in neonatal pigs https://www.biorxiv.org/content/10.1101/2025.09.12.675643v1

Time-Restricted Feeding Attenuates Kidney Damage and Preserves Renal Function in Mouse Model of Chronic Kidney Disease https://www.biorxiv.org/content/10.1101/2025.09.08.674986v1

Stem-like Prostate Remodeling in Obesity Mediates Resistance to 5α-Reductase Inhibition Therapy in BPH https://www.biorxiv.org/content/10.1101/2025.09.08.674969v1

Effects of anti-RANKL, Zoledronate or combination therapy in a mouse model of Fibrous Dysplasia: a preclinical study https://www.biorxiv.org/content/10.1101/2025.09.08.672330v1

Investigating high pathogenicity avian influenza virus incursions to remote islands: Detection of H5N1 on Gough Island in the South Atlantic Ocean https://www.biorxiv.org/content/10.1101/2025.09.06.674618v1

ATF4 alleviates doxorubicin-induced cardiomyopathy through H2S-mediated antioxidation https://www.biorxiv.org/content/10.1101/2025.09.03.674119v1

Isolation and Characterization of Potential Pathogenic Fungi Associated with Watermelons in Southwest Mississippi https://www.biorxiv.org/content/10.1101/2025.09.05.674577v1

Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk https://www.biorxiv.org/content/10.1101/2025.09.08.674895v1

MSI.EAGLE: An Open-Source GUI for Streamlined Mass Spectrometry Imaging Analysis https://www.biorxiv.org/content/10.1101/2025.09.03.673811v1

Mitosis detection in the wild using detection transformers https://www.biorxiv.org/content/10.1101/2025.09.03.673198v1

Deep tissue optical 3D imaging reveals preferential preservation of extra-islet β-cells in late-onset Type 1 Diabetes https://www.biorxiv.org/content/10.1101/2025.09.03.673632v1

Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations https://www.biorxiv.org/content/10.1101/2025.09.02.673874v1

Clinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components https://www.biorxiv.org/content/10.1101/2025.09.02.673845v1

FibroTrack: A Standalone Deep Learning Platform for Automated Fibrosis Quantification in Muscle and Cardiac Histology https://www.biorxiv.org/content/10.1101/2025.09.02.673720v1

Gene expression profiling of bovine raw milk is linked to the inflammatory status of the udder https://www.biorxiv.org/content/10.1101/2025.09.03.671445v1