The Journal of Neurodevelopmental Disorders (@jnd-springernature.bsky.social)

Pathogenic variants in CDKL5 cause an X-linked variable neurodevelopmental disorder with seizures, autism and cognitive impairment. Mottolese et al. report in vitro&vivo effects of a ciliary neurotrophic factor-like peptide on neuronal growth. jneurodevdisorders.biomedcentral.com/articles/10....

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Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder - Journal of Neurodevelopmental Disorders Background Mutations in the X-linked CDKL5 gene underlie a severe epileptic encephalopathy, CDKL5 deficiency disorder (CDD), characterized by gross motor impairment, autistic features and intellectual... https://jneurodevdisorders.biomedcentral.com/articles/10.1186/s11689-024-09583-4