Our NAR paper is officially out (doi.org/10.1093/nar/...). Digging in to how TFs work as a function of where they bind, what they bind to and which promoter they regulate on synthetic promoters designed to be regulated ONLY by that TF. Huge effort by both Sunil and Vinu.

How does a TFs function depend on the promoter it regulates? We know that a TF can have different effects on different promoters. For example, consider this case: CpxR regulates ldtCp, yccAp, efeUp at a similar location. Yet two of them are activated, one repressed #GeneReg 🧪 tinyurl.com/3hr9njnd