(@michaelpacold.bsky.social)

Out now: rdcu.be/evxCv We've used CoQ10 headgroup intermediates to treat mouse models of a mitochondrial disease and improve the neurological symptoms of a patient with this disease. Grateful for funding from @damonrunyon.org , Pershing Square Foundation, @americancancersoc.bsky.social, NIH!

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Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari... https://www.nature.com/articles/s41586-025-09246-x