Article from the UK focusing on advocacy for peanut allergy prevention drawn in part from current JACI article (pubmed.ncbi.nlm.nih.gov/36521802/) on early introduction of peanuts. www.the-independent.com/news/uk/home...

The September issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Personalized Medicine. Special thanks to Mohamed Shamji, who helped coordinate this issue. Read the Editors' Choice summaries here (free): authors.elsevier.com/a/1ljA5Ks2xL...

The August issue of JACI is now online! jacionline.org/current This month's theme focuses on Complement. Special thanks to Kathleen Sullivan, who helped coordinate this issue. Read the Editors' Choice summaries from the August issue here (free): authors.elsevier.com/a/1lYd6Ks2xL...

While over 50% of U.S. children test positive for common allergens, only ~7% of Amish children do. Asthma rates run just 1–2% in Amish Children vs. ~8–10% in non-Amish kids. Their secret? See this Washington Post article that cites research from JACI. wapo.st/4odEBmq

The July issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Endotypes in Allergy/Immunology. Read the Editors' Choice summaries from the June issue here (free to read/download): authors.elsevier.com/a/1lN0bKs2xL...

Clinical trials of therapies for asthma and food allergy are complex, and there is intense interest in the development of biomarkers to predict natural disease history and response to therapy. Read a summary of a US FDA-hosted workshop discussion. bit.ly/4juKdVD

Our understanding of the genetic etiology of allergic diseases has grown significantly in recent years. Read about key advances in the field, with a focus on common genetic variants that increase disease risk. bit.ly/45CWrIr

Climate change is affecting outdoor and indoor allergen exposures, and diagnostic and treatment strategies should limit exposure and facilitate desensitization. An American Academy of Allergy, Asthma & Immunology Work Group Report shares 4 steps. Read on. bit.ly/4kP95bB

Birth cohort studies have provided invaluable insights into risk factors for allergic diseases and asthma in children. They also have their limitations. Should we standardize population descriptors, exposures, and outcomes measures from diverse cohorts? bit.ly/4mJBHoJ

Traditionally, birth cohort studies are longitudinal, prospective observational studies of parents and their children. A Paradigms and perspectives piece discusses how birth cohort studies are evolving to incorporate methodologic innovations. Read on. bit.ly/3SyhzIn

The use of administrative data, or data from research-independent repositories, offers a valuable tool for birth cohort studies. It also brings challenges. How have administrative data have enhanced asthma, allergy, and immune disorder birth cohorts? bit.ly/43M6fgK

Studies of human IgE and its targeted epitopes on allergens have been limited. A study now shares a molecular map of the IgE antibody response to key peanut allergens. The issue also includes editorial commentary on the findings. bit.ly/3ZhS6Xc

The June issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Birth Cohorts. Special thanks to Tina Hartert and Andrea Apter, who helped coordinate this issue. Read the Editors' Choice summaries here: authors.elsevier.com/a/1lCq7Ks2xL...

Data from a phase 2 trial of GR1802, a novel anti-IL-4Ra monoclonal antibody, for the treatment of patients with uncontrolled chronic rhinosinusitis with nasal polyps suggest that the treatment is well-tolerated and effective. Here’s more. bit.ly/44F8VPn

Rocuronium is widely used to assist in mechanical ventilation. In a small number of anesthesia cases, it can lead to anaphylaxis. New data shed light on the underlying mechanisms and suggest novel diagnostic tools for rocuronium hypersensitivity. bit.ly/3SJJ15H

Human IgE mAbs that recognize peanut allergens are now available. How do these IgEs target allergens? Read about a structural map of the IgE antibody response to two key peanut allergen proteins. The issue includes editorial commentary on the findings. bit.ly/3Zftm1O

New data suggest that chronic rhinosinusitis with nasal polyps pathobiology may involve autoreactive humoral immunity, with some cases exhibiting molecular mimicry-driven autoimmune features triggered by microbial infections. Read the Editors’ Choice paper. bit.ly/3YP6Dtf

Short-chain fatty acids have been shown to be locally produced in areas of the body other than the gut in response to disease. What role might local short-chain fatty acid concentrations hold in obstructive airway diseases? Here’s a Brief report. bit.ly/430eTJy

Why do some upper respiratory illnesses provoke asthma exacerbations while the majority do not? An Editors’ Choice study identifies transcriptome-wide gene expression changes associated with common colds that progress to asthma exacerbation. Learn more. bit.ly/44EGKQL

Airway inflammation plays a key role in asthma, and the contributing molecular pathways, especially in type 2 inflammation characterized by eosinophilia and higher fractional exhaled nitric oxide, are not clear. Read new findings here. bit.ly/4jRGcM1

Rhinoconjunctivitis phenotypes are described based on aeroallergen sensitization and symptom severity and seasonality. Do these phenotypes fully reflect patterns of symptoms at a population level in children with asthma? Read Editors’ Choice findings. bit.ly/4keX9jc

Since 1993, the American Academy of Allergy, Asthma & Immunology has spent almost $11 million in Faculty Development awards to support the growth of our junior colleagues. Almost all have gone on to attain faculty appointments. Meet the 2025 awardees. bit.ly/3S4boeT

Chronic rhinosinusitis is associated with a disruption of the sinonasal microbiome, and a better understanding may open new treatments. Here’s a Paradigms and perspectives review on epithelial cell innate immunity and important open questions. bit.ly/3SrJCct

Dysregulated function of the prostaglandin E2 (PGE2) system contributes to many features of chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease. Read what we know and the pathogenic and therapeutic implications. bit.ly/3ETbVgM

There have been major advances in the treatment of chronic rhinosinusitis with nasal polyps, but disease returns upon discontinuation and there is no targeted anti-inflammatory approach. Recent data on epithelial barrier dysfunction suggest new avenues. bit.ly/43FN60b

An alarmin is a molecule that is rapidly released to alert the immune system through the engagement of specific receptors on immune cells. Learn what we know about the role of the novel alarmin TNF-like cytokine 1A (TL1A) in inflammatory conditions. bit.ly/436CjM5

Hyperinflammation has been associated with rare autoinflammatory disorders, but advances in omics technologies have revealed it to be more common, occurring in sepsis and severe coronavirus disease 2019. Learn about the key role of omics in this shift. bit.ly/4jPeUpD

Hyperinflammation has been associated with rare autoinflammatory disorders, but advances in omics technologies have revealed it to be more common, occurring in sepsis and severe coronavirus disease 2019. Learn about the key role of omics in this shift. bit.ly/4jPeUpD

Deficiency of ADA2 causes a complex phenotype of autoinflammation and immunodeficiency. The mechanisms underlying the disease on a cellular level remain unclear. A review inspects characteristics of the ADA2 protein and its proposed function. bit.ly/4dbR58P

Aspirin exacerbated respiratory disease occurs in an estimated 15% of patients with chronic rhinosinusitis with nasal polyps and/or asthma. Read a review of novel mechanistic findings and recent advancements in clinical understanding and management. bit.ly/44pBsZd

Three biologic therapies are currently approved to treat chronic rhinosinusitis with nasal polyps. Here’s a review of clinical trial and real-world data on effectiveness and safety, outcomes of biologic therapy versus surgery, and future directions. bit.ly/3YAEB4C