Del Valle Lab at ND
@delvallelab.bsky.social
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Organic synthesis and chemical biology lab at Notre Dame... Putting the 'PEP' in peptides.
Ever wondered how intra-strand staples impact beta-sheet stability? Check out our @J_A_C_S paper on an easy method to promote peptide folding and amyloid seeding activity. Congrats to Abha and Isaac!!
pubs.acs.org/doi/10.1021/...
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Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding
Side chain stapling of cysteine (Cys) residues offers convenient entry into constrained peptides with enhanced bioactivity and bioavailability. Despite its widespread application in the constraint of ...
https://pubs.acs.org/doi/10.1021/jacs.5c06944
2 months ago
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