NEW ARTICLE: In Science Advances, an investigation of the malarial parasite Plasmodium falciparum's PPCS enzyme, part of the CoA biosynthesis pathway. A collaboration between the Auclair, Creek, Corry, Strauss, and Saliba groups, spanning Canada and Australia. www.science.org/doi/10.1126/...

Some updates: The Auclair lab congratulates Aracelli Chang on a successful Master's thesis submission! And we're happy to officially welcome Dr. Jacob Pierscianowski back as a post-doc! Dr. Jake defended his thesis with us last year.

One decade ago: the Auclair lab first examined small molecules to resensitize bacteria to macrophages. #chemsky #biosky doi.org/10.1002/cbic...

It's a full queue kind of day #chemsky

Congratulations to Natalia for receiving a PROTEO graduate scholarship! proteo.ca/en/news-and-...

Freezer defrosting day means freezer sorting day #chemsky

First thiol smell of the new year. And it's not even a particularly noxious one! #chemsky

We're officially back for the new year. The built-up freezer ice looks so neat it's almost a shame to de-ice it all.

This is our freezer for the next few hours #chemsky

Check out some of the great work being done by our collaborators in the Schmeing lab in Biochemistry! In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes. #chemsky #biochemsky www.linkedin.com/posts/canlig...

Prof. Auclair presented at the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) annual symposium last week!

Come find us at @concordia.ca Loyola campus for CBGRC this Friday!

NEW PREPRINT: An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium. We investigate the mechanisms of action of these compounds and their use with in vivo mouse models. doi.org/10.1101/2025...

NEW PREPRINT: An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium. We investigate the mechanisms of action of these compounds and their use with in vivo mouse models. doi.org/10.1101/2025...

Here's some more balanced centrifuge arrangements #chemsky

We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis! Congratulations to Dr. Jake on the amazing work.

Good Wordle yesterday.

Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky

The Auclair Lab welcomes two new members! Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects. Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.

Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.

Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday. Talk about good timing #chemsky

Many members of the Auclair lab hosted and attended the student-led Careers After Chemistry conference! #CAC2025 #chemsky

Literal green chemistry #chemsky

Doing a little setup for our new baby 👀

New instrument 🔜🔜🔜

Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5. cacmcgill.wixsite.com/cac2025/regi...

The Auclair lab went tree trekking recently! Super fun teambuilding exercise.

Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!

‼️NEW PAPER ALERT In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU. doi.org/10.1128/aac.... 🧵

Another day, another paper 😌

‼️NEW PAPER ALERT In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU. doi.org/10.1128/aac.... 🧵

Balloons! #chemsky

Finding the volume of our milling balls: if it was good enough for Archimedes, it's good enough for grad students #chemsky

A wonderful moist-solid #chemsky

It's gel day #chemsky

The samples are extra colourful today #chemsky

Throwback: in 2012, our lab investigated prodrugs - activated by the CoA pathway - to resensitize resistant bacteria to aminoglycoside antibiotics. #chemsky doi.org/10.1021/cb20...

🚨NEW PREPRINT ALERT: In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies. Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky doi.org/10.1101/2025...

🚨NEW PREPRINT ALERT: In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies. Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky doi.org/10.1101/2025...

Well done to Aracelli and Alec for their great presentations! Late evening or early morning, they did wonderfully. #CSC2025 #chemsky

Look for Aracelli at the poster session tonight at 6 pm, and Alec is giving a presentation tomorrow at 8 am in the #medchem section! #chemsky

Three of our own - Prof. Auclair, Alec, and Aracelli - are presenting at @ciccheminst.bsky.social #CSC2025 in Ottawa this week!

Worth a shot #chemsky

Latest advances in cursed but balanced centrifuge arrangements #chemsky

Nitrogen tank went completely empty last week... that's what two LCMS on one tank will do #chemsky

‼️NEW ARTICLE ALERT ‼️ Dr. Ali Zaker, a recent post-doctoral fellow with the Auclair lab, investigated scaling up mechanoenzymatic depolymerization of PET plastic in a roller mill. The paper is online now in @acs.org Sustainable Chemistry and Engineering! #chemsky doi.org/10.1021/acss...

‼️NEW ARTICLE ALERT ‼️ Dr. Ali Zaker, a recent post-doctoral fellow with the Auclair lab, investigated scaling up mechanoenzymatic depolymerization of PET plastic in a roller mill. The paper is online now in @acs.org Sustainable Chemistry and Engineering! #chemsky doi.org/10.1021/acss...

Our very own Tarasha is a TV star now! She appeared on CBC News Montreal as part of McGill's Chemistry Outreach program, demonstrating the wonders of science to kids (and a few adults.) [We only have a video of the broadcast, but it's still worth a watch...!]

The team took advantage of the Montreal heat wave with a picnic!

Don't touch that dial...news 🔜