loading . . . Why Your Treatment Isnโt Working: The 3 Questions Your Brain Needs Answered This video explains why prediction is the missing link in mental health recovery and how three specific questions can transform the way we use medication and therapy.
In this episode, consultant psychiatrist Dr Sanil Rege (MBBS, MRCPsych, FRANZCP) breaks down why so many people feel โstuckโ despite trying multiple antidepressants, therapies, and programs โ and how a simple, neuroscience-based shift can restart progress.
Instead of asking only โDo you feel better?โ, Dr Rege shows why the brain needs clear predictions of what โbetterโ actually looks like in day-to-day life before it can change. Youโll learn three core questions that anchor treatment, reduce โtrial and error,โ and turn vague goals into measurable movement.
#mentalhealth #depression #anxiety #psychiatry #psychology #neuroscience #DrRege #therapy #antidepressants #recovery #emotionalhealth #braintraining #selfunderstanding #prediction ๐ง
โฑ๏ธ Chapters
00:00 โ The 3 questions that change everything
01:42 โ Why so many treatments โdonโt workโ: the missing anchor
02:31 โ The brain as a prediction machine (and why vague goals fail)
03:29 โ Question 1: What does improvement look like?
04:14 โ Question 2: What does feeling better look like?
05:00โ Question 3: Do you know what you need in each emotion?
07:52 โ Rethinking medication trials using clear predictions
10:43 โ Your brain wasnโt built for happiness โ it was built for movement
๐ What this video covers
โขWhy non-response is often misunderstood โ itโs not always the wrong medication or therapist, but a missing treatment anchor
โขHow the brain as a prediction machine uses expectations, feedback, and safety to drive change
โขThe 3 key questions:
1.What does improvement look like? โ concrete, functional predictions, not perfection
2.What does feeling better look like? โ specific snapshots, not vague โbetterโ
3.Do you know what you need when you feel each emotion? โ linking sadness, anger, fear to needs and actions
โขEmotions as signals of unmet needs (comfort, fairness, safety, being heard) and how clearly naming needs changes behaviour and relationships
โขHow repeated, predictable validation and safety are internalised in the brain, calming the amygdala and strengthening prefrontal regulation
โขA practical way to review antidepressants and other meds using defined targets (e.g. getting out of bed earlier, fewer morning ruminations) instead of yes/no โit workedโ
โขWhy routines, pacing, and structure are โnutrients of neuroadaptation,โ not just lifestyle advice
โขThe shift from โAm I happy?โ to โWhere am I moving?โ โ using cognition as the map and emotion as the engine for movement in recovery
๐ง For clinicians
-A simple framework to structure reviews beyond symptom checklists
-Make medication trials less random by tying them to clear functional goals
-Phrases to explore needs, emotions, and predictability in-session
-Use prediction + safety + neuroadaptation without overcomplicating consults
๐ค For patients, families, and carers
-Turn โI want to feel betterโ into concrete, realistic targets
-Everyday examples of what โbetterโ looks like (sleep, work, connection)
-Spot what you need when you feel sad, angry, anxious or afraid โ and say it clearly
-Use routines, pacing and consistent support to make treatment feel safer and more effective
๐ Resource: 3-hour masterclass at Academy.psychscene.com: https://www.academy.psychscene.com/courses/diagnostic-formulation-in-psychiatry/
Relevant Resources:
PACES Model: https://youtu.be/o-B4pnQwc_s?si=KNysGTl9wG9SXIvK
๐Psychiatry Training: https://www.academy.psychscene.com
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๐ LETโS CONNECT!
Follow Sanil Rege on LinkedIn: https://www.linkedin.com/in/sanilrege https://www.youtube.com/watch?v=Vi9Opuvwk4s