Happy to serve! 🧲 #NMR

TTPD #7 with @fraserlab.com. We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations. wankowiczlab.com/2025/09/27/T... Spotify: open.spotify.com/episode/0JCB...

Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data. These are plots of funding probability fas a function of percentile score for 9 institutes. 1/7

So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion".

I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal.

Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants. We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15. Even if this ends up being temporary, it’s time we don’t have.

I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share: www.sun-sentinel.com/2025/06/14/d...

In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course).

Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC

Basic science saves lives and fuels the economy, which is why I’m advocating for: ➡️NIH & NSF to spend FY25 funds ➡️$51.3B for NIH, $9.9B in FY26 ➡️Restoration of many canceled NIH & NSF grants Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123.... #ScienceServesUsAll #ASBMBAdvocates

No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...

Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:

Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu

NIH adds about 100 billion/yr to the economy

Budget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem

Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here: nature.com/articles/s41... @vubasicsciences.bsky.social

TV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2

Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/

Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!

Some new language appeared in the HHS Grants Policy Statement last week. It doesn't apply to NIH grants (yet) 1/n

In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.

Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges. www.nrimpact.com

Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."

The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below). open.spotify.com/show/10PHVou...

Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social

⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬 Give to the CSB: www.givecampus.com/campaigns/57... Give to the Karpay Award: www.givecampus.com/campaigns/57...

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

Sunday morning elliptical workout entertainment thanks to @stephanieaw.bsky.social @fraserlab.bsky.social

We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL

Fast, fair, and PAID peer review! WTG @danielgorelick.bsky.social 🙌

…and treatments for bladder cancer!

RNA2025 will feature long talks by: Jennifer Doudna David Tollervey Ling-Ling Chen Matt Disney Tracy Johnson Erin Schuman And 151(!!!) high quality additional talks. Great engagement at poster sessions. Many prizes. Stay at the conference site. Be there or be square!

Now published! Read our newest story! doi.org/10.1038/s414...

ATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...

I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!

😳🤯. Dr. Laurer was the coauthor of the memo yesterday acknowledging that the NIH funding freeze was illegal and directing staff to resume issuing grants.

We need one of these for our lab

This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...

Application deadline extended to Feb 14, 2025! Do you know any undergraduate students interested in structural biology? Check out this summer program at Meharry Medical College in Nashville TN!

Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Hey all, I know it’s a sewer, but the main action and fight on the NIH is over on Twitter. We could use your voice. I’ve already been contacted by reporters based on posts over there, it’s your best chance to be heard.

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

White House budget proposal may slash NSF funding from 9 billion to 3 billion a year.

Not #nuclearreceptors

Welcome to BlueSky, new/old #nmrchat followers! 😊🧲 ▶️ Don’t miss out - check out not one, but five (!) magnetic resonance starter packs! Discover familiar names to follow. ✅ To follow everyone on the list, just tap the upper right corner! 🤓 or tick each 🤠 bsky.app/profile/nmr9... #NMRchat #NMR

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

Just sitting in my office, saying "that seems bad" out loud to myself every hour or so.

Extremely disappointed to see HHMI decide to kill their Inclusive Excellence program, including terminating the current IE3 awards to over a hundred institutions effective this year in the middle of a 6-year grant. I was hoping HHMI (and other private funders) would continue to lead the way.