JRL EChem Lab @ Illinois (@jrl-electrochem.bsky.social)

Faster, better, self-driving electrochemical measurement: the crowning achievement of our recently minted Dr. Mike Pence, showing synergy of simulation and experiment for molecular electrocatalysis. Enjoy! pubs.acs.org/doi/10.1021/...

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Closed-Loop Navigation of a Kinetic Zone Diagram for Redox-Mediated Electrocatalysis Using Bayesian Optimization, a Digital Twin, and Automated Electrochemistry Molecular electrocatalysis campaigns often require tuning multiple experimental parameters to obtain kinetically insightful electrochemical measurements, a prohibitively time-consuming task when performing comprehensive studies across multiple catalysts and substrates. In this work, we present an autonomous workflow that combines Bayesian optimization and automated electrochemistry to perform fully unsupervised cyclic voltammetry (CV) studies of molecular electrocatalysis. We developed CV descriptors that leveraged the conceptual framework of the EC′ (where EC′ denotes an electrochemical step followed by a catalytic chemical step) kinetic zone diagram to enable efficient Bayesian optimization. The CV descriptor’s effect on optimization performance was evaluated using a digital twin of our autonomous experimental platform, quantifying the accuracy of obtained kinetic values against the known ground truth. We demonstrated our platform experimentally by performing autonomous studies of TEMPO-catalyzed ethanol and isopropanol electro-oxidation, demonstrating rapid identification of kinetically insightful conditions in 10 or less iterations through the closed-loop workflow. Overall, this work highlights the application of autonomous electrochemical platforms to accelerate mechanistic studies in molecular electrocatalysis and beyond. https://pubs.acs.org/doi/10.1021/acs.analchem.5c00099