The resulting dataset paints a relatively comprehensive picture of oncogenomics in cats and also provides a basis for insights into comparative biology of cancers in cats and human patients. www.science.org/doi/10.1126/...

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

DrugCLIP an open-source database screening 10,000 human proteins against 500 million molecules www.science.org/doi/10.1126/...

Discovery of Novel CBP/p300 and BRD4 Dual-Target PROTACs with Potent Antitumor Activity in Prostate Cancer pubs.acs.org/doi/10.1021/...

Emerging landscape of KRAS inhibitors in cancer treatment www.cell.com/cancer-cell/...

Hallmarks of cancer—Then and now, and beyond www.cell.com/cell/fulltex...

Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy pubs.acs.org/doi/10.1021/...

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism www.nature.com/articles/s41...

This review summarizes the current standard of care for glioblastomas, as well as novel therapies under evaluation and future directions. academic.oup.com/neuro-oncolo...

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 | Science www.science.org/doi/10.1126/...

Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer www.cell.com/cancer-cell/...

Long-range cholinergic input promotes glioblastoma progression www.cell.com/cancer-cell/...

First-line immunotherapy with or without chemotherapy versus BRAF plus MEK inhibitors for patients with BRAFV600E-mutated metastatic non-small cell lung cancer: The FRONT-BRAF study. ascopubs.org/doi/10.1200/...

Past, present and future of drug conjugates for cancer therapy www.nature.com/articles/s43...

Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment www.nature.com/articles/s41...

Leveraging WNT Hyperactivation to Kill Colorectal Cancer While Rejuvenating Healthy Intestine www.biorxiv.org/content/10.1...

First-line immunotherapy with or without chemotherapy versus BRAF plus MEK inhibitors for patients with BRAFV600E-mutated metastatic non-small cell lung cancer: The FRONT-BRAF study. ascopubs.org/doi/10.1200/...

A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers www.cell.com/cancer-cell/...

A chemical epigenetic tool to probe site-specific DNA-binding protein complexes www.pnas.org/doi/10.1073/...

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer www.science.org/doi/10.1126/...

First-line immunotherapy with or without chemotherapy versus BRAF plus MEK inhibitors in BRAFV600E-mutated metastatic non-small-cell lung cancer (FRONT-BRAF): a multicentre, retrospective cohort study www.thelancet.com/journals/lan...

De novo design of phospho-tyrosine peptide binders [new] Designs binders for phosphorylated tyrosine sites on clinically relevant targets using a deep generative framework, enabling modulation of signaling pathways.

The top-ranked country this year, as it was last year, is tiny Switzerland. Sweden comes second and America third econ.st/46EuZKN

How Much Water and Energy do Data Centers Consume? A New Jersey Bill Demands Answers. insideclimatenews.org/news/2409202...

Combinatorial prediction of therapeutic perturbations using causally inspired neural networks www.nature.com/articles/s41...

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability jamanetwork.com/journals/jam...

The immune microenvironment of colorectal cancer www.nature.com/articles/s41...

Aspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with PIK3CA hotspot mutations www.nejm.org/doi/full/10....

Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer www.sciencedirect.com/science/arti...

Load and lock: An emerging class of therapeutics that influence macromolecular dissociation www.science.org/doi/10.1126/...

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation www.sciencedirect.com/science/arti...

Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer #proteindegradation #protacs aacrjournals.org/clincancerre...

Arvinas rules out a solo vepdegestrant launch www.oncologypipeline.com/apexonco/arv...

T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma aacrjournals.org/cancerdiscov...

Why Your Name Matters www.newyorker.com/tech/annals-...

Brainshuttle platform from Roche. Looking forward to see clinical trials coming up with this platform in neuroscience and neuro-oncology www.roche.com/stories/clev...

Sleeping’ cancer cells in the lungs can be roused by COVID and flu www.nature.com/articles/d41...

Unveiling the hidden interactome of CRBN molecular glues www.nature.com/articles/s41...

Response and Resistance to RAS Inhibition in Cancer aacrjournals.org/cancerdiscov...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis www.nature.com/articles/s41...

Response and Resistance to RAS Inhibition in Cancer aacrjournals.org/cancerdiscov...

PARP inhibitor in solid tumors ascopubs.org/doi/10.1200/...

An unexpected career in cancer metabolism www.nature.com/articles/s43...

The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types www.nature.com/articles/s43...

A first-in-class EGFR-directed KRAS G12V selective inhibitor www.cell.com/cancer-cell/...

San Diego now ranked 9th most expensive city in the United States timesofsandiego.com/business/202...

Updated Efficacy and Safety From the Phase 2 PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic NSCLC‒A Brief Report www.jto.org/article/S155...

Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer www.nejm.org/doi/full/10....

Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment www.biorxiv.org/content/10.1...

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets www.cell.com/cancer-cell/...