(@orentzfadia.bsky.social)

Our latest paper is out! It describes mutations from >32,000 isolates, mapped on the 3D structures of ESX-1 related proteins: journals.asm.org/doi/full/10....

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Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets | Microbi... We mapped all non-synonymous single nucleotide polymorphisms onto each of the experimental and predicted ESX-1 proteins’ structural models and inspected their placement. Varying sizes of conserved reg... https://journals.asm.org/doi/full/10.1128/spectrum.03816-23