Sangsoo Lee
@sangsoolee.bsky.social
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Research Associate at Johns Hopkins Neurology/Neuroscience Sleep, Circadian Rhythms, and more!
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It’s been a rewarding journey studying sleep as a postdoc, and I’m now exploring faculty positions in neuroscience. My latest work uncovers a neural mechanism for homeostatic sleep. Open to opportunities and always happy to chat! 🔗
linkedin.com/in/sang-soo-lee-55b395295
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https://linkedin.com/in/sang-soo-lee-55b395295
7 months ago
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Honored to receive the Sleep Research Society Foundation's Career Development Award (2026–2027) to support my work on neural circuit mechanisms of sleep homeostasis. Grateful to the SRS Foundation and to everyone who has supported this journey.
3 months ago
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The Wu Lab at @JohnsHopkins is looking for a new postdoc fellow to study sleep and/or circadian-related behaviors in mice. If you're interested in, please contact us.
www.markwulab.net
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Wu Lab
https://www.markwulab.net/
6 months ago
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reposted by
Sangsoo Lee
Seth Blackshaw
6 months ago
Our latest preprint is out, focusing on characterizing the response of Lhx6-positive neurons of the zona incerta (ZI) to naturally-occurring and experimentally-induced changes in the need to sleep, also known as sleep pressure.
www.biorxiv.org/content/10.1...
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Sleep pressure is differentially regulated by molecularly distinct subtypes of Lhx6-positive and Lhx6-negative neurons of the zona incerta
Sleep pressure, the accumulating drive towards sleep during wakefulness, is shaped by Lhx6-positive GABAergic neurons in the zona incerta (ZI). Here, we show that these neurons are broadly activated b...
https://www.biorxiv.org/content/10.1101/2025.07.30.667705v1
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A new paper from the Wu lab: "A subcircuit in the suprachiasmatic nucleus generates wakefulness", now published online in Advanced Science. Congrats all, in particular Qiang Liu!
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness
This study identifies a sub-circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub-circuit is labeled by the clock output molecule mWAKE, which suppresse...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202505131
7 months ago
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It’s been a rewarding journey studying sleep as a postdoc, and I’m now exploring faculty positions in neuroscience. My latest work uncovers a neural mechanism for homeostatic sleep. Open to opportunities and always happy to chat! 🔗
linkedin.com/in/sang-soo-lee-55b395295
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https://linkedin.com/in/sang-soo-lee-55b395295
7 months ago
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I'm thrilled to share that my postdoctoral work is now published in
@science.org
. We uncovered a new circuit mechanism that regulates homeostatic sleep in mice. Huge thanks to all collaborators and supporters!
www.science.org/doi/10.1126/...
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Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep
Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...
https://www.science.org/doi/10.1126/science.adm8203
8 months ago
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I'm excited to share my first post with some great news; our study on sleep homeostasis has been accepted! I’ll share more details once it’s published!
10 months ago
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Just moved! I’ll be posting updates about my research and scientific things here!
10 months ago
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