Aitor Aguirre, Ph.D.
@aaguirre1980.bsky.social
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Stem cell biologist, cardiovascular researcher and bioengineer interested in organoid biology.
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Aitor Aguirre, Ph.D.
Cell Stem Cell
3 months ago
Online Now! Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
#stemcells
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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate cardiac development and conduction and, under chronic inflammation, recapitulate atrial fibrillation features, offering a powerful model to study immune-cardiac interactions and arrhythmia mechanisms.
http://dlvr.it/TNw7my
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Our new paper in Cell Stem Cell introduces human heart–macrophage assembloids — the first, highly sophisticated organoid model of immune–cardiac interactions.
#NAMs
#Organoids
#CardiacResearch
#CellStemCell
#AFib
#NIH
#MSU
Link to the paper:
www.cell.com/cell-stem-ce...
loading . . .
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate card...
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00367-4
3 months ago
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