The DCRI had a strong presence at #AHA25, with over 40 sessions spanning presentations, discussions, forums, and more. Browse highlights from our impactful thought leadership and expert insights in our conference recap: dcri.org/news/dcri-re... #MedSky #CardioSky

Revealing safety results from the KARDIA-3 study at #AHA25, Neha Pagidipati shared that single doses of the novel, long-acting RNAi therapy zilebesiran showed an acceptable safety profile. The ZENITH trial is now enrolling and will evaluate the therapy’s impact on CV outcomes.

DCRI’s Tyler Cope shared a key piece of the RACE-CARS trial team’s efforts to make a difference in out-of-hospital cardiac arrest outcomes during an #AHA25 poster session. The ongoing initiative is engaging 30 counties to incentivize their businesses to train employees in CPR.

DCRI’s Nishant Shah joined NBC News to discuss research presented at #AHA25 on a new treatment that has the potential to cut dangerous cholesterol levels in half with just one treatment. Watch here: www.nbcnews.com/video/new-ex...

DCRI faculty member Jennifer Rymer brought her expertise in peripheral procedures to the #AHA25 Simulation Zone - engaging directly with trainees through hands-on learning and sharing insights from her extensive experience as a Duke interventional cardiologist.

DCRI fellow Satoshi Shoji presented findings on the clinical and economic burden of ATTR-CM in HF patients at #AHA25. Patients with this condition face higher readmission risk and healthcare costs, highlighting the need for enhanced post-discharge strategies to improve outcomes.

AHA president-elect and DCRI Chief of Cardiology Manesh Patel, MD offered a thoughtful and nuanced discussion of the OPTIMA-AF trial at #AHA25, emphasizing the complexity of noninferiority trial design and implications for clinical practice.

Sharing results from a first-in-human gene therapy trial for patients with HFpEF at #AHA25, DCRI’s Marat Fudim highlighted encouraging safety data and improved wedge pressure among five patients from the initial cohort in the MUSIC-HFpEF trial.

DCRI fellow Allison Levin, MD, MSc, joined us at the DCRI booth 3401 to discuss the abstract she presented at #AHA25, which focused on mortality rates and cause of death in congenital heart disease populations.

DCRI founding director and faculty member Rob Califf, MD, highlighted the importance of speaking out and sharing one’s values during a session discussing the impact of the One Big Beautiful Bill Act on Friday afternoon at #AHA25.

“The failing heart is like an engine out of fuel,” DCRI’s Svati Shah observed in her Thursday morning presentation at #AHA25. Shah’s presentation highlighted how the heart draws energy from fats, glucose, ketones, and amino acids, and how this balance shifts in heart failure.

What is Manesh Patel, DCRI faculty member and new volunteer president-elect for the AHA, looking forward to the most at #AHA25? New insights, discoveries, and most of all, how to improve care for patients.

It's day one of #AHA25! Today's DCRI events include sessions featuring Svati Shah, Marat Fudim, Neha Pagidipati, and Robert Califf. See the schedule below for times and locations.

#AHA25 starts tomorrow! We'll be posting rundowns of sessions and events featuring those from the DCRI, news from the conference floor, and more. Be sure to follow as to not miss a thing!

📢 New Episode Alert! From obesity to diabetes and beyond, GLP-1s are changing the landscape of care. In the final episode of the Beyond the Endpoint Obesity Series, Dr. Jennifer Green helps connect the dots between research, outcomes, and what’s next. dcri.org/blog/s2-ep-5...

A new joint study from ATI Physical and the DCRI found that a no copay physical therapy led to lower rates of costly health care services for those with musculoskeletal conditions. Read more: dcri.org/news/no-copa... #clinicalresearch #MedSky

For DCRI's Neha Pagidipati, she believes that when GLP-1s "are more accessible to more people, the number of lives that are going to be changed is going to be tremendous." Learn more about these hot-topic drugs on latest Beyond the Endpoint episode: dcri.org/blog/s2-ep-4...

A recent study led by DCRI’s Jennifer Rymer suggests one long-held DST belief, that these time jumps can lead to an uptick in myocardial infarctions, may not be the case. Read more: www.medscape.com/viewarticle/...

📢 New Episode Alert 📢 GLP-1s and the Evidence That Matters Part 2 of our obesity series features Dr. Neha Pagidipati breaking down what research really tells us about GLP-1 medications, and what to expect in the future. 🎧 Check out the episode! dcri.org/blog/s2-ep-4...

According to @who.int , bacterial “superbugs” have been on the rise globally, with North Carolina being no exception. DCRI’s Tom Holland offers his insights what's contributing to this increase, and what can be done in the long-term to address this problem: www.wral.com/lifestyle/he...

DCRI’s Stephen Greene duke joined AJMC for a Q&A on his recently published viewpoint in JAMA Cardiology to discuss the future and practical implications of optimizing quadruple foundational therapies for patients with heart failure. Read & listen at: www.ajmc.com/view/aggress...

Season 2 of Beyond the Endpoint is well under way, with hosts Emily O’Brien and Manesh Patel diving deep into all things clinical research. Catch new episodes every other Wednesday, and find all the past and current episodes at: dcri.org/bte-podcast/... #MedSky #podcast

📢 New Episode Alert: “It’s Not Just the Scale: Supporting Sustainable Change in Obesity Treatment” In Part 1 of our obesity series, Emily O’Brien and Manesh Patel dive into what sustainable weight change really looks like with Jennifer Norris, PA-C. dcri.org/blog/s2-ep-3...

A recent analysis of the CARE-HK registry indicates that a reduced risk for death may balance out concerns about hyperkalemia when treating heart failure with RAS inhibitors MRAs. Learn more about the findings, featuring insights from DCRI’s Stephen Greene: www.medscape.com/viewarticle/...

Millions of Americans with heart failure struggle to get the medications they need. Yet a new Duke Health led by DCRI Faculty member Adam DeVore showed that a remote care program provided patients with a safe and accessible way to get the care required: corporate.dukehealth.org/news/remote-...

Have you listened to the latest Beyond the Headlines episode of our Beyond the Endpoint podcast? Tune in on your preferred streaming platform, and let us know what topics you'd like to see hosts Emily O'Brien and Manesh Patel cover in a future episode! dcri.org/blog/s2-ep-2...

At #ESC2025, AQUATIC trial results showed aspirin is harmful for those with OAC 6+ months removed from PCI. Discussant & DCRI Faculty member Renato Lopes said these results show the importance of randomized trials to find “the antithrombotic sweet spot”: www.tctmd.com/news/aquatic...

Cognitive functional therapy, an individualized approach to managing chronic pain, has shown promising results as a way to treat back pain. DCRI Faculty member Steven George and other experts share their thoughts on the treatment: www.washingtonpost.com/wellness/202...

🚨 New Episode Alert: Season 2’s Beyond the Headlines Series kicks off with Emily O’Brien and Manesh Patel unpacking what’s making waves in medical news: • Funding research • Vaccines • Sleep Health • AI in Healthcare 🎧 Tune in for the full conversation! dcri.org/blog/ep-2-be...

New research featuring DCRI’s Stephen Greene assessed the effects of GLP-1RAs on heart failure hospitalization and cardiovascular death across populations with varying type and number of CKM comorbidity, finding the treatment helped reduce deaths. Read more: onlinelibrary.wiley.com/doi/10.1002/...

At #ESC2025, PARACHUTE-HF lead investigator & DCRI Faculty member Renato Lopes shared how the study results are "a first step in the right direction" for those heart failure caused by Chagas disease. Read more about the results: www.tctmd.com/news/parachu... #CardioSky #clinicalresearch

In a recent editorial for JAMA, DCRI’s Gerald Bloomfield shares his perspective on the WHO STEPS program, emphasizing how new STEPS surveys must not only track risk, but also help countries define and deliver cardiovascular health: jamanetwork.com/journals/jam...

We’re excited to announce that Matt Healy will be joining the DCRI! Matt will serve as a member of the DCRI Executive Team, and will assume the role of Chief Operating Officer on November 1. Join us in extending a warm welcome to Matt!

DCRI Faculty member Jennifer Rymer served as the lead author on a new study of nearly 170,000 patients that showed no significant increase in heart attacks during the weeks surrounding daylight saving time. Read more: medschool.duke.edu/news/dayligh... #CardioSky

🚨 BTE Season 2 is here! Dr. Lauren Franz joins hosts Emily O'Brien and Manesh Patel to explore how research informs care and helps families with navigating autism. dcri.org/blog/s2-ep-1... #autism #beyondtheendpoint #clinicaltrials

Season 2 of Beyond the Endpoint kicks off tomorrow! Tune in to our season premiere episode Understanding Autism: Insights from Research and Practice, which dives into autism research, care, and community. #podcast #autism #clinicalresearch

DCRI’s Manesh Patel recently joined HCPLive to discuss the new AHA & ACC hypertension guidelines, explaining key takeaways like the increased emphasis on lifestyle changes, GLP-1 receptor agonists, and exciting future treatments and trials: www.hcplive.com/view/updatin... #CardioSky

At the recent #ESCCongress, DCRI faculty shared late-breaking study results & participated in discussions on cardiovascular challenges. Get the rundown on the two late-breaking “Hot Line” presentations from Neha Pagidipati and Renato Lopes here: dcri.org/news/dcri-fa...

The latest DCRI Accomplishments story highlights recent achievements from faculty members Manesh Patel, Julius Wilder, Gerald Bloomfield, and Scott Palmer, as well as this year's Excellence Award winners. Read more: dcri.org/news/dcri-ac...

It's the first day of #ESCCongress! We'll be posting rundowns of DCRI sessions each day of the conference. Today, DCRI's Nishant Shah will be sharing his presentation on comorbidities and prognosis in chronic coronary syndromes. #clinicaltrials #clinicalresearch #cvd

Season 2 of the DCRI's Beyond the Endpoint podcast is right around the corner! Get a sneak preview of what topics you can expect to see covered below, and catch up on any episodes from season 1 you might have missed here: dcri.org/bte-podcast/...

DCRI Fellow Ben Catanese shared his thoughts on a recent study that explored the association of eGFR slope with progression of pre-clinic heart failure (HF) to clinical HF. Read the full article on ‪@ajkd.bsky.social: ajkdblog.org/2025/08/20/o... #clinicaltrials #MedSky

DCRI’s Nishant Shah was one of the experts who participated in a new article covering the American Heart Association National Integrated ASCVD Initiative, which increased lipid management referrals and LDL-C monitoring across 6 sites. Read more: www.ahajournals.org/doi/full/10.... #CardioSky

Did you know the mitochondria may play a key role in treatment for diseases such as Alzheimer’s and Parkinson’s? DCRI’s Laurie Sanders shares insights into the research her and her team did on mitochondrial dysfunction and Parkinson’s: www.nih.gov/news-events/... #clinicaltrials #clinicalresearch

New results show a simplified two-dose antibiotic treatment may be just as effective as long-term IV therapy for serious staph bloodstream infections. For DCRI Faculty member Thomas Holland, this represents a “a meaningful shift” in treatment: corporate.dukehealth.org/news/two-dos...

While current GDMT scores capture omissions and underdosing, they may miss speed and delays. DCRI’s Stephen Greene and Satoshi Shoji reflect on this need to track initiation and capture any delays in a new editorial for the American Heart Association: www.ahajournals.org/doi/10.1161/... #CardioSky

Donna Parker, Director of DCRI’s i-Cubed, recently joined Alloy Partners for an insightful conversation on how innovation, entrepreneurship, and cross-industry partnerships are shaping clinical trials. Listen to the full episode here: www.alloypartners.com/articles/adv... #clinicaltrials #podcast

V-INTERVENTION, a new clinical trial led by the DCRI, will explore whether the early use of a cholesterol-lowering medication can help reduce major cardiac and limb events in people who have had a successful revascularization procedure. Learn more: dcri.org/news/victori...

A recent Duke-led found that of 570 patients with biopsy-proven MASLD, 18% developed HF, while nearly half showed signs of the disease. Study co-author Marat Fudim says the results “highlight a critical gap” in diagnosing HF for this high-risk group: dcri.org/news/study-r... #MedSky #CardioSky

New FDA approval of finerenone for HFmrEF/HFpEF could represent a significant shift in treatment. DCRI’s Stephen Greene sat down with HCPLive to discuss the new treatment options and insights from the pivotal FINEARTS-HF trial: www.hcplive.com/view/fineren... #CardioSky #heartfailure