Happy to share the latest paper from the lab looking at PARP inhibitor responses in isogenic BRCA1 cell line pairs, from the Master work of Shiella Amelia Soetomo and Michael Sharp: dx.plos.org/10.1371/jour...

I feel incredibly privileged to share this study on Fanconi anaemia, based on a small but important cohort. This work describes the genetics and clinical outcomes of patients in Australia and New Zealand with a diagnosis of FA. www.sciencedirect.com/science/arti...

🚀 Our collaborative work with @monica-pradillo.bsky.social, "Genetic dissection of MutL complexes in Arabidopsis meiosis," is now published in NAR! 🌱 doi.org/10.1093/nar/... 🔬 We show that MutLγ is crucial for ZMM-dependent crossovers, with MUS81 unable to fully compensate for its loss.

Thrilled to share our latest work on meiotic recombination, where we mapped rates and distributions by sequencing thousands of individual sperm. This study was led by Stevan Novakovic and @caitlinharris.bsky.social , in collaboration with @davisjmcc.bsky.social and Cynthia Liu.

🦘🧬Australian invited speaker list finalised for the 2025 Cell Cycle, DNA repair and Telomere Meeting! Friday 5 Sep is your last chance to register at the EARLY BIRD rate & submit an abstract 🤩 australiancellcycle.org/australian-i...

Paper accepted! Shout out to co-first authors Hannah Fluhler, Elissah Granger and Michael Sharp.

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

A recent preprint from the team, about the clinical and genetic spectrum of Fanconi anaemia in Australia and New Zealand. It also underscores the value of higher testing rates in detecting more cases. www.medrxiv.org/content/10.1...

Thanks to the team for a great year and a very chilled end of year lunch in Carlton gardens.

Congratulations to Shiella Amelia Soetomo on completing an excellent Masters thesis on developing tools to measure synthetic lethality. Shout out to co-supervisor Michael Sharp!