もろふし🕶️
@morofushi1230.bsky.social
📤 2
📥 0
📝 99
小児, 肝臓, 腎臓を勉強中. 分子生物学, 生化学, 薬学.
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression: Cell
www.cell.com/cell/fulltex...
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A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 ...
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900056-5
about 21 hours ago
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New approach methodologies for drug discovery: Cell
www.cell.com/cell/fulltex...
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New approach methodologies for drug discovery
New approach methodologies that are human-centered, such as stem cells, organoids, and in silico models, can span the full drug discovery pipeline—from disease modeling to efficacy testing—and hold pr...
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900217-5
about 21 hours ago
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Pearling drives mitochondrial DNA nucleoid distribution | Science
www.science.org/doi/10.1126/...
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Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
https://www.science.org/doi/10.1126/science.adu5646
1 day ago
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The expanding role of formulations to enable oral delivery of poorly water-soluble drugs: Nature Reviews Drug Discovery
www.nature.com/articles/s41...
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The expanding role of formulations to enable oral delivery of poorly water-soluble drugs - Nature Reviews Drug Discovery
The oral delivery of small-molecule drugs with poor aqueous solubility represents an ongoing drug development challenge. Amorphous solid dispersions (ASDs) and lipid-based formulations (LBFs) have eme...
https://www.nature.com/articles/s41573-026-01407-5
1 day ago
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Purinergic ATP-P2X7 Signaling Drives Colonic Giant Migrating Contraction in Suncus murinus: The FASEB Journal
faseb.onlinelibrary.wiley.com/doi/10.1096/...
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Purinergic ATP‐P2X7 Signaling Drives Colonic Giant Migrating Contraction in Suncus murinus
Using Suncus murinus, this study reveals that ATP regulates colonic giant migrating contractions (GMCs). ATP activates P2X7 receptors on cholinergic neurons, triggering powerful contractions that fac...
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202504538RR
2 days ago
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CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease: EMBO
link.springer.com/article/10.1...
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CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease - The EMBO Journal
Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) encodes a tRNA-modifying enzyme responsible for thiomethylation generating 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in the antic...
https://link.springer.com/article/10.1038/s44318-026-00759-3
3 days ago
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STING signalling as a mediator between lipid metabolism and innate immunity: Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
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STING signalling as a mediator between lipid metabolism and innate immunity - Nature Reviews Molecular Cell Biology
This Comment discusses the bidirectional interplay between STING signalling and lipid homeostasis, highlighting the emerging therapeutic relevance of this regulatory network.
https://www.nature.com/articles/s41580-026-00967-z
3 days ago
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Genetic study identifies novel genes in developmental dysplasia of the hip: Bone Research
www.nature.com/articles/s41...
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Genetic study identifies novel genes in developmental dysplasia of the hip - Bone Research
Bone Research - Genetic study identifies novel genes in developmental dysplasia of the hip
https://www.nature.com/articles/s41413-026-00514-8
3 days ago
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Essential role of endothelial T-cadherin in the transcytosis of circulating high-molecular-weight adiponectin to sub-vascular tissues - Metabolism - Clinical and Experimental
www.metabolismjournal.com/article/S002...
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Essential role of endothelial T-cadherin in the transcytosis of circulating high-molecular-weight adiponectin to sub-vascular tissues
Adiponectin, an adipocyte-derived protein, has diverse organ-protective effects, which are associated with its accumulation in vascular endothelial cells (VECs) as well as in various extravascular cel...
https://www.metabolismjournal.com/article/S0026-0495%2825%2900358-0/fulltext
3 days ago
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Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1: Cell Reports
www.cell.com/cell-reports...
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Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1
Kakemura et al. show that Xrp1, a key determinant of cell competition, is abundantly expressed in normal cells, but it is not translated due to an upstream ORF. They show that unfit “loser” cells caus...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2826%2900233-0
5 days ago
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DDX3X is a Cl−-sensitive RNA helicase | Science Signaling
www.science.org/doi/10.1126/...
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DDX3X is a Cl−-sensitive RNA helicase
A disease-associated mutation blocks Cl− binding from functionally affecting the RNA helicase DDX3X.
https://www.science.org/doi/10.1126/scisignal.adv4376
8 days ago
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Regulatory grammar in human promoters uncovered by MPRA-based deep learning: Nature
www.nature.com/articles/s41...
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Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature
PARM is a deep-learning model trained on data from massively parallel reporter assays to help predict promoter activity in different human cell types, design synthetic promoters and identify key featu...
https://www.nature.com/articles/s41586-025-10093-z
8 days ago
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Repair condensates and lipid domains in lysosome integrity: Trends in Cell Biology
www.cell.com/trends/cell-...
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Repair condensates and lipid domains in lysosome integrity
Lysosomes are sophisticated signaling hubs whose function depends on membrane integrity. A breach of this barrier, known as lysosomal membrane permeabilization, triggers inflammation and cell death, d...
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924%2826%2900033-4
8 days ago
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STING signaling modulation by COPII cargo recognition: Cell
www.cell.com/cell/fulltex...
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STING signaling modulation by COPII cargo recognition
Lyu et al. identify the STING-ER-exit motif and the mechanism of its recognition by the COPII vesicle cargo-binding protein SEC24C. This study reveals how STING achieves controlled rather than constit...
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900267-9
9 days ago
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Four subtypes of disease-causing missense mutations underlie pathogenic protein interactions in neurodegenerative VPS13A disease: JCI
www.jci.org/articles/vie...
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JCI - Four subtypes of disease-causing missense mutations underlie pathogenic protein interactions in neurodegenerative VPS13A disease
https://www.jci.org/articles/view/200890
9 days ago
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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion: Nature
www.nature.com/articles/s41...
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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - Nature
Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell r...
https://www.nature.com/articles/s41586-026-10266-4
9 days ago
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Epigenetic memory of colitis promotes tumour growth: Nature
www.nature.com/articles/s41...
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Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
https://www.nature.com/articles/s41586-026-10258-4
9 days ago
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Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy - Gastroenterology
www.gastrojournal.org/article/S001...
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Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy
Hepatic congestion activates the yes-associated protein–connective tissue growth factor axis in liver sinusoidal endothelial cells through integrin αV, leading to liver fibrosis, portal hypertension, ...
https://www.gastrojournal.org/article/S0016-5085%2825%2906526-6/fulltext
17 days ago
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Acute peritonitis-induced adipose CD127+ ILC1s express PD-L1 and ameliorate inflammation in mice: Nature Communications
www.nature.com/articles/s41...
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Acute peritonitis-induced adipose CD127+ ILC1s express PD-L1 and ameliorate inflammation in mice - Nature Communications
The immune regulatory role of mesenteric adipose tissue (MAT) during acute peritonitis remains elusive. Here, the authors employ a cecal ligation and puncture mouse model and show that a population of...
https://www.nature.com/articles/s41467-026-69100-0
17 days ago
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle: Cell
www.cell.com/cell/fulltex...
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle
SLC25A35 is revealed as the mitochondrial PEP exporter that licenses glycerolipid synthesis in lipogenic cells, linking mitochondrial energetics to lipid production. Mitochondrial PEP flux drives glyc...
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900224-2
17 days ago
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A small polymerase ribozyme that can synthesize itself and its complementary strand | Science
www.science.org/doi/10.1126/...
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A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
https://www.science.org/doi/10.1126/science.adt2760
24 days ago
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OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours: Nature
www.nature.com/articles/s41...
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OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours - Nature
The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.
https://www.nature.com/articles/s41586-026-10149-8
about 1 month ago
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Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters: Cancer Drug Resist.
www.oaepublish.com/articles/cdr...
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Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters
Aim: Antibody-drug conjugates (ADCs) feature an antibody recognizing a specific protein joined to a potent toxic payload. Numerous ADCs have received U.S. Food and Drug Administration (FDA) approval; ...
https://www.oaepublish.com/articles/cdr.2025.151
about 2 months ago
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DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science
www.science.org/doi/10.1126/...
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DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
https://www.science.org/doi/10.1126/science.adx9445
about 2 months ago
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Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models | Science Translational Medicine
www.science.org/doi/10.1126/...
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Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models
KRAS G12D and G12C produce lung tumors with distinct microenvironmental and growth features that influence progression and survival.
https://www.science.org/doi/10.1126/scitranslmed.adq6647
about 2 months ago
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MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids: Cell
www.sciencedirect.com/science/arti...
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MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids
In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…
https://www.sciencedirect.com/science/article/pii/S0092867425014321
2 months ago
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Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation | Science
www.science.org/doi/10.1126/...
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Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...
https://www.science.org/doi/10.1126/science.adu2825
2 months ago
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Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit: Nature
www.nature.com/articles/s41...
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Client Challenge
https://www.nature.com/articles/s41586-025-09907-x
3 months ago
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p53 increases phospholipid headgroup scavenging in senescence : Nature Cell Biology
www.nature.com/articles/s41...
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Client Challenge
https://www.nature.com/articles/s41556-025-01853-0
3 months ago
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Membrane editing with proximity labeling reveals regulators of lipid homeostasis: Nature Chemical Biology
www.nature.com/articles/s41...
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Client Challenge
https://www.nature.com/articles/s41589-025-02104-x
3 months ago
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Renal PIEZO2 is an essential regulator of renin: Cell
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Renal PIEZO2 is an essential regulator of renin
The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney cells that produce...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901309-1
3 months ago
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Next steps in regulatory T cells: Biology and clinical application: Cell
www.cell.com/cell/fulltex...
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Next steps in regulatory T cells: Biology and clinical application
This perspective highlights advances in regulatory T cell biology and emerging clinical applications to modulate immune tolerance and tissue repair across multiple diseases.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901370-4
3 months ago
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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity: PLOS ONE
journals.plos.org/plosone/arti...
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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity
Drug-induced liver injury is a major concern in drug development, and the limitations of animal models have driven interest in human-derived in vitro models for toxicity assessment. HepaRG cell-based ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0339559
3 months ago
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Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development - Kidney International
www.kidney-international.org/article/S008...
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Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development
Epithelial cell polarity is crucial for the proper functioning of various organs, including the kidneys. Syntaxin 3, a key molecule in membrane-vesicle fusion, is localized in the apical membrane of p...
https://www.kidney-international.org/article/S0085-2538%2825%2900758-6/fulltext
3 months ago
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An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II | New England Journal of Medicine
www.nejm.org/doi/full/10....
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An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II | NEJM
Tividenofusp alfa, comprising iduronate-2-sulfatase fused to an engineered transferrin receptor–binding Fc domain, has been developed to treat neurologic and peripheral manifestations of mucopolysa...
https://www.nejm.org/doi/full/10.1056/NEJMoa2508681
3 months ago
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NFE2L1/Nrf1 forms a coactivator complex post-peptide:N-glycanase-mediated sequence editing and mitigates proteasome dysfunction | PNAS
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2517547123
3 months ago
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Optimizing cardiovascular pharmacotherapy in older adults with frailty: Nature Reviews Cardiology
www.nature.com/articles/s41...
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Optimizing cardiovascular pharmacotherapy in older adults with frailty - Nature Reviews Cardiology
Frailty is common in older individuals, but can occur independently of advanced age, multimorbidity or disability. In this Review, Nguyen and colleagues draw on evidence from clinical guidelines and r...
https://www.nature.com/articles/s41569-025-01244-w
3 months ago
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Chronic kidney disease - The Lancet
www.thelancet.com/journals/lan...
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Chronic kidney disease
Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. B...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2825%2901942-7/fulltext
3 months ago
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Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells | Science Advances
www.science.org/doi/10.1126/...
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Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells
Cholesterol efflux protein ABCA1 shifts macrophages to being anticancer, highlighting its potential use as a therapeutic target.
https://www.science.org/doi/10.1126/sciadv.adx5490
3 months ago
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Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances
www.science.org/doi/10.1126/...
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Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
https://www.science.org/doi/10.1126/sciadv.aeb2571
3 months ago
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Cancer cell death: Cell-autonomous and immunogenic dimensions: Cancer Cell
www.cell.com/cancer-cell/...
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Cancer cell death: Cell-autonomous and immunogenic dimensions
Galluzzi et al. discuss cell-autonoumous and immunomodulatory aspects of cancer cell death, both from mechanistic and therapeutic standpoints.
https://www.cell.com/cancer-cell/fulltext/S1535-6108%2825%2900539-2
3 months ago
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis
Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress respo...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901366-2
3 months ago
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Human assembloids recapitulate periportal liver tissue in vitro | Nature
www.nature.com/articles/s41...
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Human assembloids recapitulate periportal liver tissue in vitro - Nature
Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal...
https://www.nature.com/articles/s41586-025-09884-1
3 months ago
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Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses: Cell
www.cell.com/cell/fulltex...
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Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901358-3
4 months ago
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Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease: Cell
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Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease
Kidney podocytes of the blood-urine filter form autoimmunoglobulin-triggered extracellular vesicles (AIT-EVs) for intra- and extracellular waste removal into the urine, a cellular reaction that links ...
https://www.cell.com/cell/fulltext/S0092-8674(25)01306-6
4 months ago
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Tumour-reactive heterotypic CD8 T cell clusters from clinical samples: Nature
www.nature.com/articles/s41...
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Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
https://www.nature.com/articles/s41586-025-09754-w
4 months ago
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Designing allosteric modulators to change GPCR G protein subtype selectivity: Nature
www.nature.com/articles/s41...
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Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...
https://www.nature.com/articles/s41586-025-09643-2
5 months ago
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Parity and lactation induce T cell mediated breast cancer protection: Nature
www.nature.com/articles/s41...
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Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
https://www.nature.com/articles/s41586-025-09713-5
5 months ago
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T cell cholesterol transport links intestinal immune responses to dietary lipid absorption | Science
www.science.org/doi/10.1126/...
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T cell cholesterol transport links intestinal immune responses to dietary lipid absorption
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A link...
https://www.science.org/doi/10.1126/science.adt4169
6 months ago
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Role of AAA-ATPase Cdc48p in peroxisomal quality control: Cell Reports
www.cell.com/cell-reports...
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Role of AAA-ATPase Cdc48p in peroxisomal quality control
Yusuf et al. demonstrate that in the absence of Pex5p recycling, Pex5p is degraded via the RADAR pathway during the exponential growth phase of yeast. Using the GAL1 promoter to regulate gene expressi...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901176-3
6 months ago
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