Afshin Samali
@afshinsamali.bsky.social
š¤ 52
š„ 81
š 9
ER Stress, Unfolded Protein Response, Cancer Biology
reposted by
Afshin Samali
Zoltan Molnar
1 day ago
First-ever atlas of brain development shows how stem cells turn into neurons There are 6 excellent human brain development papers in Nature -
www.nature.com/articles/d41...
Check them out!
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www.nature.com/articles/s41...
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Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly - Cell Death & Differentiation
Cell Death & Differentiation - Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
https://www.nature.com/articles/s41418-025-01603-7
9 days ago
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Breastfeeding boosts anticancer immunity through recruitment of CD8+ T cells
www.nature.com/articles/d41...
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Breastfeeding boosts immune cells that protect against breast cancer
The protective, long-lived T cells can persist for decades after a woman gives birth.
https://www.nature.com/articles/d41586-025-03419-4
21 days ago
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reposted by
Afshin Samali
New Scientist
23 days ago
An analysis of patient records suggests that mRNA covid-19 vaccines boost the immune response to cancerous tumours when given soon after people start a type of immunotherapy, extending their lives
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mRNA covid vaccines spark immune response that may aid cancer survival
An analysis of patient records suggests that mRNA covid-19 vaccines boost the immune response to cancerous tumours when given soon after people start a type of immunotherapy, extending their lives
https://www.newscientist.com/article/2500546-mrna-covid-vaccines-spark-immune-response-that-may-aid-cancer-survival/?utm_term=Autofeed&utm_medium=SOC&utm_source=Bluesky#Echobox=1760976567
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reposted by
Afshin Samali
New Scientist
23 days ago
Scientists are designing mRNA vaccines to produce virus-like nanoparticles, which should lead to a more robust immune response with even fewer side effects than either of these immunisation approaches on their own
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Why the next generation of mRNA vaccines is set to be even better
https://www.newscientist.com/article/2500112-why-the-next-generation-of-mrna-vaccines-is-set-to-be-even-better/?utm_term=Autofeed&utm_medium=SOC&utm_source=Bluesky#Echobox=1760985561
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A new blood test has been been approved by FDA to assist in diagnosing Alzheimerās disease.
go.nature.com/47b4hIp
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Blood tests are now approved for Alzheimerās: how accurate are they?
A second blood test has been been approved by the US Food and Drug Administration to assist in diagnosing Alzheimerās disease. Will these tests change how cognitive decline is measured?
https://go.nature.com/47b4hIp
25 days ago
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reposted by
Afshin Samali
Nature
26 days ago
A new blood test to aid with the diagnosis of Alzheimerās disease has been approved by the US FDA
go.nature.com/47b4hIp
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Blood tests are now approved for Alzheimerās: how accurate are they?
A second blood test has been been approved by the US Food and Drug Administration to assist in diagnosing Alzheimerās disease. Will these tests change how cognitive decline is measured?
https://go.nature.com/47b4hIp
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reposted by
Afshin Samali
Susan Logue
4 months ago
Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
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Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry
Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...
https://www.mcponline.org/article/S1535-9476%2825%2900135-5/fulltext
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Obesity gene shields against heart disease
www.nature.com/articles/d41...
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This gene causes obesity ā and shields against heart disease
People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.
https://www.nature.com/articles/d41586-025-03387-9
26 days ago
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reposted by
Afshin Samali
Research Ireland
30 days ago
The countdown to Science Week 2025 is on š¬šļø Supported by Research Ireland, Science Week is marking its 30th anniversary this year! Festival and event details are coming soon! Stay tuned and keep an eye on
www.scienceweek.ie
for the latest updates.
#ScienceWeek
#ThenTodayTomorrow
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How
#immigration
drives winning
#science
- "Talent can be born anywhere, but opportunities are not"
www.nature.com/articles/d41...
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More than 30% of this centuryās science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
https://www.nature.com/articles/d41586-025-03247-6
about 1 month ago
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reposted by
Afshin Samali
Precision Oncology Ireland
about 1 month ago
Since 2019, POI has worked to accelerate the development of personalised cancer therapy & diagnostic options. Today we begin Stage 2 of our journey, building on strong foundations and expanding our collaborations to drive innovation & shape the future of cancer care.
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reposted by
Afshin Samali
Research Ireland
about 1 month ago
Minister James Lawless has launched Phase 2 of Irelandās leading and largest ever cancer research programme,
@precisiononcire.bsky.social
. The programme is co-funded through Research Ireland, industry and the not-for-profit sector. Read more:
www.researchireland.ie/news/precision-oncology-ireland/
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reposted by
Afshin Samali
Precision Oncology Ireland
about 2 months ago
Since 2019, POI has driven huge research impacts, from biological insights to training the next generation of researchers. On
#WorldCancerResearchDay
, weāre proud to share our new brochure, developed with science journalist Claire O'Connell, highlighting these achievements
tinyurl.com/jnhs762h
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No strong evidence for autism-Tylenol link.
www.nature.com/articles/d41...
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Trump links autism and Tylenol: is there any truth to it?
The US president repeatedly advised people, āDon't take Tylenol,ā but scientists say that strong evidence between the medication and autism is lacking.
https://www.nature.com/articles/d41586-025-02876-1
about 2 months ago
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Five problems plaguing publishing in the life sciencesāand one common cause - Wright - 2024 - FEBS Letters - Wiley Online Library
febs.onlinelibrary.wiley.com/doi/10.1002/...
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FEBS Press
Although publication in scholarly peer-reviewed journals remains the gold standard for communication of findings in the life sciences, the gold has been debased by various impurities. Here, I discuss...
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.15018
about 2 months ago
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Samali Foundation will be honoured for its work at the Mayo Irish Diaspora Society 2025 Awards ceremony, tomorrow 13 September,
#Castlebar
#Mayo
.
add a skeleton here at some point
2 months ago
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reposted by
Afshin Samali
Andrew Kellett
4 months ago
Excited to share our
@narjournal.bsky.social
work on a trackable trinuclear platinum complex for breast cancer therapy:
doi.org/10.1093/nar/...
𧬠With
@raphael-depaiva.bsky.social
@afshinsamali.bsky.social
@alicepyne.bsky.social
@westerlundlab.bsky.social
@researchireland.ie
@dcuresearch.bsky.social
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It was lovely to interview with
@sorchapollak.bsky.social
@irishtimes.com
regarding
@samalifoundation.bsky.social
#Education
#Refugee
www.irishtimes.com/ireland/soci...
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Galway hotel fire āpulled our community together to help other newcomersā, says professor
Cancer specialist recalls 2023 incident as he launches foundation to help refugees and asylum seekers access education
https://www.irishtimes.com/ireland/social-affairs/2025/06/23/galway-fire-hotel-pulled-our-community-together-to-help-other-newcomers-says-professor/
5 months ago
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reposted by
Afshin Samali
Samali Foundation
5 months ago
Launch of Samali Foundation on 17 June
@ria.ie
. Speakers included Minister Colm Brophy, Pat Guiry (President
@ria.ie
), Enda O'Neill (
@unhcr.org
Ireland),
@afshinsamali.bsky.social
,
@adriennegorman.bsky.social
(
@universityofgalway.bsky.social
), Zarghona Hassani & Ismail Mohammed.
#Refugee
#Education
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reposted by
Afshin Samali
Samali Foundation
5 months ago
Former refugee on a mission to help others
connachttribune.ie/former-refug...
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Former refugee on a mission to help others - Connacht Tribune - Galway City Tribune
Former refugee on a mission to help others
https://connachttribune.ie/former-refugee-on-a-mission-to-help-others/
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