Excited to share this Annual Review synthesizing 75+ yrs of research (150+ studies) on stress effects--from pregnancy through adolescence--on children’s mental, physical, social, and functional health. This review fills a critical gap & finds pervasive stress effects. www.ucsf.edu/news/2026/01...

#Research Readings: Self-Perceived Life Course #Sleep Duration Trajectories and Risk and Age at Onset of #ParkinsonsDisease https://www.nature.com/articles/s41531-025-01202-w

Following several AI-related delusion diagnoses since June, UCSF will soon implement routine screening for chatbot use to see if the researchers can make any connections. https://ow.ly/fnue50XUtiC

#Research Readings: Expenditures for #Pediatric #BehavioralHealth Care Over Time and Estimated Family Financial Burden https://jamanetwork.com/journals/jamapediatrics/fullarticle/2842604

In a joint effort, UCSF and Stanford plan to invite patients to voluntarily share chatbot logs to explore potential links between chatbot conversations and mental-health conditions or symptom changes. https://ow.ly/v6Ty50XUthv

#Research Readings: #Plasma Placental Growth Factor as a Susceptibility Biomarker for Longitudinal #Cognitive Change https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70936

#Research Readings: Adopting a Cascade-of-Care Approach to Examine Mental Health Service Access for Youths in the Child Welfare System https://psychiatryonline.org/doi/full/10.1176/appi.ps.20240487

Join us for an evening exploring how science is reshaping our understanding of the brain. ✨ Flash talk by Dr. Matthew State ✨ Conversation with journalist Victoria Colliver ✨ Open audience Q&A The Night of Science-making science relevant and deeply human. Register: qbi.ucsf.edu/night-of-sci...

UCSF and Stanford researchers are preparing a systematic study on how patients interact with AI chatbots, aiming to better understand the technology’s role in mental health care. More information here, https://ow.ly/bwlW50XUthG.

#Research Readings: The Waiting Room Effect: Why Diverting People with #MentalIllness From Jails Requires Broad Structural and Systemic Change https://psychiatryonline.org/doi/10.1176/appi.ps.20240386#Research

#Research Reading: #Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation https://www.pnas.org/doi/10.1073/pnas.2420623122

#Research Reading: #Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation https://www.pnas.org/doi/10.1073/pnas.2420623122

#Research Reading: A systematic review of #income and #education reporting in #psychedelic clinical trials https://www.nature.com/articles/s44220-025-00417-3

#Research Reading: Democratizing #dementia research through global online conferences https://www.nature.com/articles/s41593-025-01949-8

#Research Reading: Fostering experiential learning of #neurocognitive skills in #brain injury tele-#rehabilitation: bridging gaps in remote #training by integrating scenario-based digital experiences with #coaching https://ow.ly/LLI350XBx8p#Research

#Research Reading: Transitive prediction of small-molecule function through alignment of high-content screening resources https://www.nature.com/articles/s41587-025-02729-2

#Research Reading: Leveraging family and #caregiver support in #psychedelic-assisted therapy: considerations for the treatment of #adolescents https://capmh.biomedcentral.com/articles/10.1186/s13034-025-00930-4#Research

#Research Reading: Timing and intraindividual variability of daytime #napping and #Alzheimer’s disease in older adults https://www.nature.com/articles/s43856-025-00936-1#Research

#Research Reading: Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD https://www.researchgate.net/publication/393265726_Opposing_role_of_phagocytic_receptors_MERTK_and_AXL_in_Progranulin_deficient_FTD

⏰ STARTS IN 1 HR ⏰ UCSF DPBS #GrandRounds – "Targeting Threat and Reward Processing in the Treatment of Anxiety and Depression" with Michelle G. Craske, PhD. To access the Zoom livestream, visit psychiatry.ucsf.edu/watchgrandrounds#GrandRounds

#Research Reading: The Global #Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common #neurodegenerative diseases and #aging https://www.researchgate.net/publication/393723839

Join us tomorrow, Dec. 10, for our next DPBS #GrandRounds – "Targeting Threat and Reward Processing in the Treatment of Anxiety and Depression" – featuring Michelle G. Craske, PhD. More information, https://calendar.ucsf.edu/event/251210gr#GrandRounds

#Research Reading: Objective #sleep quality in diverse older adults: a cross-sectional study on the importance of #race and #ethnicity and sex https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04204-w

⏰ STARTS IN 1 HR ⏰ UCSF DPBS #GrandRounds – "Neuroscience and Mental Health: Past, Present, and Future" with Joshua A. Gordon, MD, PhD. To access the Zoom livestream, visit psychiatry.ucsf.edu/watchgrandrounds#GrandRounds

Join us tomorrow, Dec 9 at 8:30am for our next #GrandRounds – "Neuroscience and Mental Health: Past, Present, and Future" with Joshua A. Gordon, MD, PhD. Pritzker Bldg. Auditorium and online via Zoom. More info here, https://calendar.ucsf.edu/event/251209gr#GrandRounds

#Research Reading: Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility https://www.nature.com/articles/s41467-025-57342-3

Researchers just released the most detailed maps yet of how the brain differentiate from stem cells. In five new Nature papers, researchers tracked hundreds of thousands of early brain cells, revealing the precise molecular steps that create our neurons and support cells. https://ow.ly/pC7e50XytfV

#Research Readings: Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions https://www.nature.com/articles/s41569-025-01188-1#Research

Join us on Dec. 10 for our next DPBS #GrandRounds, featuring Michelle G. Craske, PhD. More information, https://calendar.ucsf.edu/event/251210gr#GrandRounds

In a recent study, offering buprenorphine as a switching option showed no major differences in pain or opioid reduction. Researchers suggest future work should focus on integrating buprenorphine discussions more prominently into chronic pain care plans. https://ow.ly/Zt4C50Xyteq

This week's DPBS #GrandRounds on positive psychiatry with Dilip V. Jeste, MD is now available to watch on demand. 🖥💻📱➡️ https://youtu.be/M5NSuMVxo_U?si=2_XTR7ciK4nuIeEB#GrandRounds

#Research Readings: Productivity benefits of treatment of depression and post-traumatic stress disorder in Kenya https://pubmed.ncbi.nlm.nih.gov/41184028/

Our next #GrandRounds – "Neuroscience and Mental Health: Past, Present, and Future" with Joshua A. Gordon, MD, PhD – is scheduled for next Tuesday, Dec 9 at 8:30am. Pritzker Bldg. Auditorium and online via Zoom. More info here, https://calendar.ucsf.edu/event/251209gr#GrandRounds

Recently researchers traced hundreds of thousands of developing brain cells, revealing precise molecular events that shape cognition. These atlases will help scientists pinpoint genes, pathways, and time points relevant to conditions. https://www.nature.com/articles/d41586-025-03641-0

Shira Maguen, PhD, joins filmmaker Stephen Olsson and Vietnam veteran Levie Isaacks on KQED’s Forum to discuss moral injury and its lasting impact. https://www.kqed.org/forum/2010101912003/veterans-ptsd-and-moral-injury-centered-in-documentary-healing-a-soldiers-heart

#Research Readings: Integrating expert knowledge into large language models improves performance for psychiatric reasoning and diagnosis https://www.sciencedirect.com/science/article/pii/S0165178125004895

On KQED’s Forum, Shira Maguen, PhD, talks with Healing A Soldier’s Heart director Stephen Olsson about moral injury and how it affects veterans and communities. https://www.kqed.org/forum/2010101912003/veterans-ptsd-and-moral-injury-centered-in-documentary-healing-a-soldiers-heart

#Research Readings: Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity https://www.nature.com/articles/s41398-025-03690-z

Combining genetic and cardiovascular disease risk factors may predict who is at highest risk for developing dementia, a UCSF-led study finds. Lifestyle change and improved vascular illness control could help delay or prevent symptoms, UCSF’s Shea Andrews says. https://ucsfh.org/49Boom9

Shira Maguen, PhD, joins Stephen Olsson, director and producer of the documentary “Healing A Soldier's Heart” on KQED Forum to discuss moral injury – the psychological harm experienced when personal moral codes are violated. Listen here, https://ow.ly/1bKU50XAnqv.

Join us tomorrow at 8:30am for DPBS #GrandRounds – "Positive Psychiatry: Yesterday, Today, and Tomorrow" with Dilip V. Jeste, MD. To access the Zoom livestream, visit psychiatry.ucsf.edu/watchgrandrounds

#Research Readings: The new frontier in understanding human and mammalian #brain development https://www.nature.com/articles/s41586-025-09652-1

#Research Readings: #HepatitisC virus-related liver cancer among #Medicaid recipients with #schizophrenia, 2002–2012 https://ow.ly/4tPt50XuqUE#Research#HepatitisC

#Research Reading: Transitive prediction of small-molecule function through alignment of high-content screening resources https://www.nature.com/articles/s41587-025-02729-2

Holiday dinners often bring diverse viewpoints. Instead of trying to “win” arguments, Joe Pierre, MD suggests asking: “I’m so interested in what you believe. Tell me more about this.” Compassionate listening builds trust, which helps counter misinformation long-term. https://ow.ly/1fTF50XxQOT

#Research Reading: Prevalence of chemsex and associated factors among gay, bisexual, and other men who have sex with men in Nepal: findings from an online national survey https://www.nature.com/articles/s41598-025-92449-z

Our next #GrandRounds – "Positive Psychiatry: Yesterday, Today, and Tomorrow" with Dilip V. Jeste, MD – is scheduled for next Tuesday, Dec 2 at 8:30am. Pritzker Bldg. Auditorium and online via Zoom. More info here, https://calendar.ucsf.edu/event/251202gr#GrandRounds

New research suggests that recognizing non-genetic influences may help those more vulnerable to developing #dementia. https://psych.ucsf.edu/news/could-precision-medicine-approach-help-you-delay-dementia

#Research Reading: Short- and long-term modulation of rat #prefrontalcortical activity following single doses of #psilocybin https://ow.ly/9cR350WMjvG

According to researchers, a heightened awareness of the role of non-genetic factors could help those who are at increased risk of developing #dementia. More info here, https://www.ucsf.edu/news/2025/11/431111/could-precision-medicine-approach-help-you-delay-dementia#dementia