What are Engram Cells? Learn about them with this quite long article www.cell.com/neuron/fullt... which is worth the read because it shows cognitive regeneration of Alzheimer's mice (and humans have these cells too, so it could also work for them)

Singapore scientists are figuring out more of how a known protein DTMF, alerts the brain to make fresh new cells to combat brain disease and brain aging. www.sciencealert.com/scientists-h... how can it be safely added to humans?

France continues their good progress toward an artificial heart that you can leave in there forever (fixes the need for donor organs) Currently Carmat's Aeson heart-replacer works well but is not for 'indefinite use'. See it at x.com/argosaki/sta...

Spreading the gene editing? They're trying www.newscientist.com/article/2514... you can read a snippet of how that could help with this part of an article.

1. Discover molecular messenger of aging 2. Figure out how to turn it off! It's ReHMGB1, and Korea needs to turn it off x.com/NextScience/... They published on Metabolism – Clinical and Experimental, as this is a good target for new therapies.

Yeah, it's mouse study still but Partial Cellular Reprogramming is regenerating their brains and even restoring age lost memories. www.cell.com/neuron/fullt... very long paper that explains it well: human trials when?

What's the first real AI-made drug? It's Rentosertib (a rare lung disease is fought) It took 30 months and 10x less money than the usual way, thanks to AI being used. x.com/majoragv/sta...

Programmable MRNA theraputics? That would help out with so many different diseases, www.nature.com/articles/s41... (specifically good for 'undruggable' problems) This one is a really long and complicated paper.

Well, it IS Q1 2026, and they started the human trial! www.globenewswire.com/news-release... It's ER-100, the FDA cleared it, and it's the first (one of the first?) actual human rejuvenation therapy to launch.

Rejuvenating the blood brain barrier? As it's such a key component for brain health, this is a great avenue to look into. This very long article www.nature.com/articles/s41... (may want a summary) explains what will be studied.

Another win for Semaglutide? It's now fighting arthritis independent of weight loss. (people hand-waved it before 'of course if you lose weight your joints are better--this isn't that!) www.cell.com/cell-metabol... the summary says 'actual cartilage restoration', very good news.

Quite a long article on using TCells to fight Alzheimer's www.pnas.org/doi/10.1073/... , might want to have an AI summarize this long/complex article for you as this seems like a good and new angle

News you want to hear if you...want to hear! Rinri in England has sheffield.ac.uk/research/fea... with Rincell-1, restoration of the hair cells that die/damage and cause hearing loss.

The latest from Isomorphic Labs is great news for health at www.isomorphiclabs.com/articles/the... as it moves beyond the already amazing AlphaFold3.

15-PGDH returns to the news x.com/CraigBrockie... as their trial (phase 1 on humans) is close to finishing. Inhibiting the PGDH which is a gero-enzyme that breaks cartilage may allow it to grow back properly and stop breaking down, if this works as they hope it will.

Finally a solution to endless yearly flu shots? Johnson & Johnson says it's quite possible with a nasal spray that stops EVERY flu (as you know, it changes each year) www.newscientist.com/article/2514... It's called CR9114 and you spray it up your nose 2x/day during risk of infection. (so far)

The pancreatic cancer news from Spain's top guy the other day (he had to get crowd funded--and did!) gets a deeper look by this guy in Spain as to the reasons x.com/enricross196... it's a longer tweet if you want to know more.

Stopping the "go" signal on cancer doesn't harm healthy cells and stops it in its tracks: and it's being tested on a human already. www.sciencedaily.com/releases/202... (being as this is a 2025 article) A safer approach for multiple types of cancer if/when the trial succeeds.

The last 7 days have apparently been quite something for discoveries x.com/m_goes_dista... including anti-cancer progress around the world and accelerating experiments with AI help to discover more things faster and for less money.

Kidney Conversion? There is now! An enzyme converts a kidney into Type 0 to transplant into anyone, and this is what it looks like news.ubc.ca/2025/10/univ... (And that was back in 2025, so they're even further along now!)

Let's talk anti-aging with a longer article... x.com/VraserX/stat... Lots of speculation, but this stuff should be discussed.

Usually this avoids rumors...but this seems a bit more substantial, x.com/Kekius_Sage/... billionaires and Nobel prize winners looking to longevity could mean amazing news to end disease if it's the real deal.

The NAD vs Alzheimer's appears updated around January 20th as well on Cell www.cell.com/cell-reports... this one's a bit of a deeper dive article, but it looks like good news.

The NAD levels vs Alzheimer's article re-appeared around Xmas of last year, www.sciencedaily.com/releases/202... so it's a good chance to read up on it now with an easy article

Only the 2nd month into the year and already we've got another anti-aging/rejuvenation trial entering for humans NOW longevity.technology/news/retro-b... RTR242, is a small-molecule therapy designed to restore lysosomal function in humans to fight brain diseases.

Remember Spain pancreatic cancer-curing triple-drug therapy guy from the other week? Somehow despite that being totally amazing he apparently got de-funded. So everyone RE-funded him! www.patreon.com/posts/150156... Let's get this cured ASAP!

What is vitrification? It's all about preserving brains and it just took a good step forward at this article www.biorxiv.org/content/10.6... They're trying it on rabbits and getting interesting progress.

What's ok about the fda? It's not everywhere on earth. This article highlights problematic areas x.com/jasonwilliam... of an organization created to help keep people safe, but that itself could use some improving.

Trial success! Remember that Japanese 'grow a new tooth for you' trial? Well it's just finished in humans with 0 side effects. x.com/kosuke_agos/... hopefully everyone can get this before 2030 (their year of aiming) as it is doing better than expected.

What are Transcription Factor Perturbations? Here's a twitter article with their study for rejuvenation x.com/bryan_johnso...

The curing of pancreatic cancer in mice over in Spain has gotten so much traction it made it to Reddit www.reddit.com/r/Damnthatsi... credibility and excitement increases.

The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes www.unilad.com/news/health/...

A THIRD way to fix up teeth? We've got Japan's method, England's method, and now a patch in Korea that's already on human trials x.com/argosaki/sta... good stuff out of Seoul University if this works by 2026 (keep your teeth!)

A long and complicated one, but worth a read (or an AI summary) www.frontiersin.org/journals/agi...

A synthetic human chromosome? England's going to try it x.com/argosaki/sta... because the Wellcome Trust with $13.7 million in funding has got a 5 year plan to see if they can. It'll be interesting to see where this one goes.

MIT's technology review reports further on Life Biosciences www.technologyreview.com/2026/01/27/1... and it's the eye/blindness study still and an important place to start.

Can't read much of it at endpoints.news/exclusive-fd... but the FDA greenlighting a study on total-cell reset by Life Biosciences is pretty much amazing news.

In the UK it's recently proven that rapamycin protects immune cells (in humans) from DNA damage. Rapamycin isn't new news by any means but www.medsci.ox.ac.uk/news/rapamyc... this new test of it seems to be.

"Celebrity nonsense"? Not really. This stuff is actually important x.com/realNathanCh... , super richies like Elon and people talking about longevity over at Davos along with curing 'all disease' in the foreseeable future is the kind of posting you want to see.

What's CLAIR-3? The latest AI training to spot cancer in humans before anyone else. medicalxpress.com/news/2026-01... Hong Kong professors are using it to detect cancer earlier to fight it more effectively.

Drugging the un-druggable? Degrading proteins is an important part of stopping disease. www.nature.com/articles/s41... this paper brings a new nano angle and a would-be easier approach (rather than case-specific) Yes, it would fight types of dementia also if they can get it working.

Switzerland develops a nanofilter able to get Alzheimer's amyloid out of the blood x.com/argosaki/sta... but can it get it out of the brain too? Currently people's insurance is putting up a fight. What can anyone do?

Are motor neurons a key to longevity? They work differently than all the other cells. This interesting article tells you more about their angle x.com/BiluHuang/st...

Needs some sources but this is looking good x.com/argosaki/sta... nanoparticles vs. Alzheimer's in a new way (protein called LRP1) It's still personalized/testing, but more approaches are needed and this one seems decent.

A treatment for movement disorders, Focused Ultrasound, has been revealed to fight Alzheimer's too as of January in China www.scmp.com/news/china/s... if this is an actual cure, wow. They're already testing it on humans now.

Cancer and Alzheimer's are rarely in the same person & they're learning why. www.nature.com/articles/d41... it may be cystatin C, which gets accidentally activated by having cancer, but then helps the brain. It's an all new angle to investigate.

Given the previous post...maybe it really is a 'heard it here first' because now here comes a youtube video about it www.youtube.com/watch?v=6ph2...

Immune cells moving telomeres? Mice living 17 months longer than usual? This one's got the potential to really take off, hopefully this is a 'heard it here first' www.biorxiv.org/content/10.1...

Want to read more about the Biotech Singularity? (and do you have a lot of time because this is long) www.sciencedirect.com/science/arti... there are loads of linked studies and good sources here too.

He's done it once, now he's going to do it again. (He also went to prison for a while about it too.) www.wired.com/story/china-... Frankly, he ought to succeed. Alzheimer's is the scourge of the world and must be stopped. Hopefully he edits some adults for it right away.