Trompouki lab Ircan Nice France
@trompoukilab.bsky.social
📤 402
📥 249
📝 11
Interested in
#hematology
#RNAsensing
in
#zebrafish
and
#mouse
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation: Cell
www.cell.com/cell/fulltex...
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Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation
This study reveals that composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900803-7
about 2 months ago
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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy: Cell
www.cell.com/cell/fulltex...
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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses, inclu...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900156-4
7 months ago
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www.cell.com/cell/abstrac...
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A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...
https://www.cell.com/cell/abstract/S0092-8674(25)00102-3
7 months ago
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www.nature.com/articles/s41...
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Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
https://www.nature.com/articles/s41586-024-08443-4
8 months ago
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www.sciencedirect.com/science/arti...
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A new hypothesis to explain disease dominance
The onset and progression of dominant diseases are thought to result from haploinsufficiency or dominant negative effects. Here, we propose transcript…
https://www.sciencedirect.com/science/article/pii/S0168952524002919
9 months ago
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www.nature.com/articles/s41...
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Monoallelic expression can govern penetrance of inborn errors of immunity - Nature
Somatically determined preferential allelic expression of select genes that when mutated cause inborn errors of immunity corresponds with disease phenotypes, suggesting that the penetrance and express...
https://www.nature.com/articles/s41586-024-08346-4
9 months ago
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www.nature.com/articles/s41...
10 months ago
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www.nature.com/articles/s41...
10 months ago
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A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing
doi.org/10.1126/scie...
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A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing
Down-regulation of BCL11A protein reverses the fetal (HbF, α2γ2) to adult (HbA, α2β2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo ...
https://doi.org/10.1126/science.adp3025
10 months ago
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