🚨 New @CircAHA #ESC2025 SimPub alert! 🚨 HCM isn’t just driven by rare Mendelian mutations. This study highlights the role of intermediate-effect variants (IEVs)—variants with moderate effect & low penetrance—in shaping disease expression. #HCM #SoMeEditor tinyurl.com/HCM-IEVs

1/ In this #OriginalResearch paper in @ahajournals.bsky.social, Bellamo et al evaluate Lp(a) as a prognostic marker for incident and secondary vascular disease in participants from the UK Biobank Here's a🧵summarizing key aspects of paper 🔗http://bit.ly/3HkLhP6 Let’s unpack the findings ⤵️