Check out our the structure of a DNA-guided Cas12a. It uses the DNA hairpin to mimic structural cues to recognize a target RNA. Gnarly. www.biorxiv.org/content/10.6...

Great work by @kaitlynakiernan.bsky.social! Glad we had her in our group before she moved on to her next adventure!!

Fabulous grad student Grace Hibshman has solved the structure of FnCas9 with its scaRNA to show how it switches roles to transcriptional repression by bypassing nuclease activation. Check out her talk at CRISPR2025 in NZ! www.biorxiv.org/content/10.1...