Ian Silverman
@iansilverman.bsky.social
📤 22
📥 239
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Precision Oncology, Translational Genomics, Molecular Diagnostics.
reposted by
Ian Silverman
Sylvain Gigan
about 1 year ago
Happy birthday Google Scholar - making my life easier since 2004.
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reposted by
Ian Silverman
vonMeyenn Lab @ ETH Zurich
about 1 year ago
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!
www.nature.com/articles/s41...
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Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
https://www.nature.com/articles/s41586-024-08165-7
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Pleased to share our latest work on genomic- and methylation-based
#ctDNA
analysis of baseline samples from patients with
#DDR
and
#HRD
tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in
#ATM
www.medrxiv.org/content/10.1...
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Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profiling
The development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i...
https://www.medrxiv.org/content/10.1101/2024.11.11.24316049v1
about 1 year ago
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