Building a network of lymphoma researchers on @bsky.app. Let us know who we’re missing! 🔬 go.bsky.app/KbjoCuC

Lab night out on Broadway! 🎭 A well-earned pause from experiments. 🧬

Huge congratulations to my postdoc Jiali Yu 👏 who has been awarded a fellowship from the National Cancer Center. She’ll be investigating how chromatin remodelers contribute to the onset and progression of blood cancers. So proud and excited for what’s ahead. 🚀

Huge congrats to *Ari Melnick* on being appointed the Director of the Josep Carreras Leukemia Research Institute in Barcelona! 🙌 👏

🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social! 🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬

🚨Our new prepint 🚨 ▶️ When a bromodomain goes rogue Rsc1 bromodomain 2 doesn’t bind acetyl-lysines. It grabs DNA instead — and yeast cells die 💀 without it. Plot twist? Read our preprint: 👉 www.biorxiv.org/content/10.1... #chromatin #bromodrama #DNAlover And a 🧵👇 1/5

Absolutely fantastic work from the magnificent @davidlabmsk.bsky.social lab! Incredible science and amazing out-of-the-box approach. Congrats to all the authors and highly recommend the read. 🙌

Nearly every medicine we benefit from started with NIH-funded research. Early discovery work starts in academia. Immunotherapies? Gene therapy for rare diseases? Alzheimer’s and Parkinson’s medicines? Vaccines? Novel cancer treatments? Psychiatric medicines? You betcha. 1/

Impressed by Genome-Shuffle-seq. 🔀 “Multiplex generation and single-cell analysis of structural variants in mammalian genomes”. www.science.org/doi/10.1126/...

Long-read sequencing just got an upgrade. 📢 Genome, methylome, epigenome & transcriptome in one go—haplotype-resolved & at single-molecule resolution. 🔥

PRINT is finally out. 🖨️ Highly recommend this paper! Congrats to Buenrostro group and all the authors. 🙌 “Multiscale footprints reveal the organization of cis-regulatory elements.” www.nature.com/articles/s41...

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics

#ASH2024 Highly recommend this place for lunch. Also, highly recommend the company @jchellmuth.bsky.social!

Closest I know of is lymphoma research from @darkobar.bsky.social: bsky.app/starter-pack...

Great morning session with Panagiotis Ntziachristos on Lymphoid Oncogenesis – Molecular Insights Into Lymphoma and CLL. #ASH2024

Huge congrats to Béguelin lab at Weill Cornell. Fantastic new work showing how PRC2 inhibition boosts T cell immunotherapies. Out now in Cancer Cell. www.cell.com/cancer-cell/...

Good news, Altmetric has now started watching BlueSky for mentions of publications. And by the way, provides an easy comparison between this and the old site for a recent preprint of mine which I posted simultaneousl at both. Numbers speak by themselves !

H3-H4 histone dimers act as copper reductase. This is important because ETC and SOD1 require bio-usable Cu+ for function. This article shows a new mechanism by which chromatin histones can affect the cell metabolism via a new role in metal processing #redoxepigenetics www.science.org/doi/10.1126/...

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER. doi.org/10.1038/s415...

Happy Thanksgiving from Weill Cornell fourteen floor groups! 🦃 🇮🇹 🇨🇳 🇦🇷 🇺🇸 🇭🇷 🇷🇺 🇵🇱 🇺🇿 🇰🇷 🇫🇷 🇬🇷

Please help me curate a Lymphoma Research Starter Pack by suggesting folks to add or messaging me to be added yourself. Looking forward to more lymphoma topics on BlueSky. 🙌

Very interesting paper from @mitchguttman.bsky.social previously in @biorxivpreprint.bsky.social out in Nature Genetics. "ChIP-DIP generates context-specific protein localization maps at consortium scale" www.nature.com/articles/s41...

starter pack 2 for all things #chromatin, #transcription, and adjacent: go.bsky.app/Q5sXc6E - reply to self-nominate or suggest colleagues! check out pack 1: go.bsky.app/5zgpZfg and @sproullab.bsky.social's pack: go.bsky.app/TKp9YAn for more people to follow

www.nature.com/articles/s41... Single-molecule states link transcription factor binding to gene expression Deep insights into multiple facets of TF binding, accessibility & expression with biophysical models of single molecule data by Ben Doughty, Michaela Hinks, Bintu & Greenleaf labs

cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers. www.nature.com/articles/s41...

Beautiful and fundamental paper about Polycomb-mediated gene repression by @kjarmache.bsky.social Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1 www.nature.com/articles/s41...

Nucleosome flipping drives kinetic proofreading and processivity by SWR1. Very cool story. 🙌 www.nature.com/articles/s41...

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

Thrilled to share we are @theNCI R00-funded. 🥳 Looking for computational biologists or bioinformaticians. 👩‍💻👨‍💻 We have many exciting projects on the role of chromatin remodelers in blood cancers. 🩸🦀 Please share/DM/email if relevant. Our latest story: www.cell.com/cancer-cell/...

New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL