Jeremy Schwartzentruber (@jeremy37.bsky.social)

Let’s talk about rare variant association tests - we have a new method that helps you discover more with the same data! It’s called *FlexRV* to signal our approach: “flexibly modeling rare variant pathogenicity improves gene discovery for complex traits”. www.biorxiv.org/content/10.1...

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Flexibly Modeling Rare Variant Pathogenicity Improves Gene Discovery for Complex Traits Rare variant burden tests can directly identify genes that influence complex traits, but their power is limited by our ability to separate functional from benign alleles. We introduce FlexRV, an appro... https://www.biorxiv.org/content/10.1101/2025.11.04.686320v1