Jacob A Hoffman
@jahoffman1.bsky.social
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PhD - Penn - Wilson Lab - AAVxGlycobiology MIT - Novo Nordisk AI Postdoctoral Fellow - Belcher Lab
reposted by
Jacob A Hoffman
Jon Lim, MRCP PhD
11 months ago
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇
bioart.niaid.nih.gov
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Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered
#glycan
profiles between mouse, NHP and human liver, with implications for translation of
#AAV
#genetherapy
pubmed.ncbi.nlm.nih.gov/39001819/
Enjoy!
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Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed
Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...
https://pubmed.ncbi.nlm.nih.gov/39001819/
11 months ago
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Hi
@bsky.app
#glycobiology
community! Seems pretty sweet over here
11 months ago
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