Nature research paper: Whole-genome landscapes of 1,364 breast cancers go.nature.com/48PM7Or

Registration for our next edition of Liquid Biopsies is now open 🎉 Join world-leading experts and emerging investigators to explore the latest advances in circulating nucleic acids, circulating tumour cells & extracellular vesicles across the cancer continuum. eacr.org/conference/l...

You have until 15 December to register for our upcoming virtual conference! We will explore a seemingly paradoxical approach to cancer therapy, based on the deliberate hyper-activation of cancer-relevant signalling pathways. Register from €60: eacr.org/conference/o...

There's no better day than #WorldCancerResearchDay to register for our next virtual conference, Patient Involvement in Cancer Research! Learn how to make your research better and more impactful. Registration closes on Monday. Learn more: eacr.org/conference/p...

EACR members! Join us for an interactive workshop on scientific publishing, where expert scientific editors will guide you through the essential steps of getting your research into the academic spotlight. 📅 29 September, 14:00-15:30 CEST 🌍 Zoom us02web.zoom.us/meeting/regi...

Stand out in your career & boost your research impact 💥 Funders & journals now expect real patient involvement. Join this event to get practical insights to collaborate better & future-proof your research. Registration closes 29 Sept - don’t miss it! 👉 eacr.org/conference/p...

New @dev-journal.bsky.social editorial We know we have high standards - but we're committed to making publishing with us constructive From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science journals.biologists.com/dev/article/...

Nature Careers reports on how a new generation of researchers are using Substack as a way to build audiences and monetize their knowledge. #Academicsky 🧪

Join us this November in Bergamo to help shape the future of early-onset cancer research! We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients. In partnership with @themarkfdn.bsky.social 💙 eacr.org/conference/m...

Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers www.cell.com/molecular-ce...

We used ~normal human mammary epithelial cells (HMECs) to test CDH1 loss (modeling ILC) vs inhibiting E-cadherin, i.e. genetic suppression vs signaling block, to define how CDH1 loss is fundamentally different that 'simply' losing E-cadh mediated cell contacts. I.e. is this ~EMT, or not? 2/n

As we learn more re CDH1 loss-induced lineage reprogramming, we can develop new risk assessment strategies for benign ILC precursors, build prevention strategies, and target "truncal" effects of CDH1 loss in overt ILC to target the changes that likely are important in every single cancer cell. 5/5

So CDH1 loss causes a lineage remodeling in normal HMEC, locking cells in a new luminal progenitor-like state. This may explain why nearly all ILC are luminal-type (i.e. ER+) and point to CDH1 loss as a critical "bottleneck" in breast oncogenesis specific to ILC. 4/n

We did a thing w @jostrander.bsky.social! Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n

🚨 New podcast episode! In this insightful and honest conversation, award winners Karin de Visser, Ido Amit and @martakova.bsky.social talk about their research, career journeys, and excitement for the future of cancer research: magazine.eacr.org/curiosity-op...

If you're traveling this weekend (like I will for the EACR Congress in Lisbon) this is a great way to learn something new while waiting on trains and airports. The Cancer Researcher Podcast is available on all major podcast platforms!

As part of the Cancer Researchers to Watch – An Early Career Showcase, the EACR Early Career Researchers Council took a moment to brainstorm with the early-career EACR members in the audience strategies that would better support the next-generation cancer scientists. #EACR2025

New online! The evolutionary foundations of transcriptional regulation in animals

What a wonderful week we’ve had here together in Lisbon for #EACR2025! Thank you to everyone who attended, presented at and helped organise this fantastic event. Sign up here for updates about EACR 2026 in Budapest… 👀 eacr.us5.list-manage.com/subscribe?u=...

Participants, speakers and exhibitors have been taking the chance to relax and mingle with a drink at the #EACR2025 Welcome Reception here in Lisbon.

Full house to attend to Eileen White keynote lecture on Cancer Metabolism with special focus on cancer cachexia! #EACR2025

Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!

How do tumors escape immune system? Outstanding presentation Prof. Karin de Visser honored with the Pezcoller–Marina Larcher Fogazzaro–EACR Women in Cancer Research Award 2025. A truly inspiring opening to #EACR25

Acquired resistance in cancer: towards targeted therapeutic strategies www.nature.com/articles/s41...

Great overview on the evolving landscape of HER2 testing — from HercepTest to next-gen quantitative tools — and why precise detection of HER2-low matters more than ever in the era of ADCs. www.nature.com/articles/s41...

LBCA has developed a new patient resource: Myths and Facts about Invasive Lobular Carcinoma to help clear up common and pervasive myths about invasive lobular carcinoma (ILC). Read it here: lobularbreastcancer.org/myths-vs-fac...

ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer doi.org/10.1038/s430...

Seung Hyun Lee's EACR Travel Fellowship experience shows the value of embracing new environments and challenges in your life as a researcher, allowing you to accelerate your development and contribute meaningfully to the global fight against cancer:

Are you preparing for an upcoming interview in a science-related field? Don't miss our next interactive workshop is designed to equip you with the skills you need. 📅 09 June at 15:00216:30 CET 🌍 Zoom us02web.zoom.us/meeting/regi...

We’re campaigning to #KeepResearchCurious because early-stage, curiosity-driven cancer research is the cornerstone of future medical breakthroughs 🔍 #EWAC2025

New @nature.com An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer www.nature.com/articles/s41...

Organoids are a promising breakthrough. These 3D tissue cultures grown from human stem cells stand to revolutionize some aspects of biomedical research, but they won’t eliminate the need for animal testing entirely. actu.epfl.ch/news/the-pro...

Beautiful work from 🇨🇭@neuroxepfl.bsky.social #EPFL #CHUV

Here's a key graph from that piece expanded

📭 Are you attending 'Defence is the Best Attack: Immuno-Oncology Breakthroughs‘ and are interested into our call for papers? Check Details here ➡️ febs.onlinelibrary.wiley.com/hub/journal/... or ➡️ talk to our editor Ruzhica Bogeska on site. @helloeacr.bsky.social

What a beautiful location for the #EACR 'Defence is the Best Attack' conference - at the CosmaCaixa Science Museum, Barcelona 🧪 Excited for 3 great days of impactful science 🤩 @helloeacr.bsky.social

The milk-producing structures, called Terminal Ductal Lobular Units (TDLUs), serve as the functional units of the human milk factory. Shown here is a section of #breast tissue stained with carmine alum, highlighting the epithelial structures of the mammary gland. Truly #fascinating! #Science

Cells as living drugs is a big part of future medical approaches. There's been so much about engineering T cells (CAR-T) for treatment of cancer and autoimmune diseases. But engineering macrophages (CAR-M) is next up for blocking inflammation. www.nature.com/articles/s41...

We're looking for a Scientific Operations Project Manager to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...

In this Review, Chantelle Rizan and colleagues discuss the role of the endocrinologist in mitigating the environmental effects of healthcare, with a focus on endocrine-disrupting chemicals (£) go.nature.com/3GoeasI #EndoSky #WorldHormoneDay #BecauseHormonesMatter

#Breast picture of the day or should I say painting? Here's a 3D reconstruction of the human breast rendered into an artistic painting using AI tools! It really does look like something that belongs in a modern gallery. #Science #Art

Have you ever wondered what it would be like to pursue a career in scientific management? What skills are valued in this sector and what are the opportunities for career progression? Tune into this episode of The Cancer Researcher Podcast:

Did you catch our latest podcast episode? Hear from @charlesswanton.bsky.social who discusses his research interests and some of the challenges he faced in his early career ahead of his Keynote Lecture at the upcoming EACR Congress: magazine.eacr.org/charlie-swan...

This week’s 3D reconstruction of the human #breast highlights the #myoepithelial cells- the contractile cells that help squeeze the milk-producing luminal cells to release milk and nourish offspring. Truly fascinating! #Science #Art

“Students have come up to me to say, ‘I’m studying cancer research because of this review. I feel like a rock star.” 🧪 These are the 25 most-cited papers published this century https://go.nature.com/4ilZw2q

Uncovering synthetic lethal vulnerabilities across cancers. Upregulation of #TWIST1/2, #VIM, and integrin components ( #ITGB5, #ITGAV, #FERMT2 ) constitutes a synthetic lethal buffering mechanism that preserves tumor fitness despite #CDH1 #Ecadherin loss #lobular #DGC www.nature.com/articles/s41...

Our review on Dormancy and EMT received enough views to be a Top Viewed and Cited Article. Read about it here: onlinelibrary.wiley.com/doi/full/10.... #TopViewedArticle @wiley.com

Turning my Bluesky profile into a merge of #science 🔬 and #art 🎨: an exhibition featuring the beauty of the #breast through #microscopy. Starting with one of my favorites: 3D reconstruction of the human breast; Staining: Smooth muscle actin; Cells: Myoepithelial cells.

Story time! We are excited to share our new Biorxiv pre-print which we hope will also find a home in a peer-reviewed journal soon: "GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers" www.biorxiv.org/content/10.1...

showing true (!) synthetic lethality www.nature.com/articles/nat... www.nature.com/articles/nat...