🧪 Read JPET's recent Editor's Choice, which suggests that inhibition of BRG1 could be a novel mechanism for combating paclitaxel resistance and enhancing the potency of chemotherapeutic agents: https://ow.ly/8jLk50XVJt3

Rami Shahror, PhD, is the JPET Highlighted Trainee Author for January 2026. His research focuses on identifying proteins linked to harmful blood vessel formation in the retina due to ischemia, which can lead to retinopathy and vision loss. ➡️ Read here: https://doi.org/10.1016/j.jpet.2025.103738

📢Make sure to sign up for today's webinar, designed for healthcare educators eager to enhance their teaching methodologies and student outcomes. This webinar is open to both ASPET members AND non-members.🧪 Learn more and register here: https://ow.ly/HGy650XWSLV

Congratulations to the 2026 recipients of an ASPET Editorial Fellowship. This program offers senior post-doctoral fellows and junior faculty members the opportunity to build important skills as a peer reviewer and as an editor.

Vrishali Salian, PhD, a Postdoctoral Associate at the University of Minnesota, is the Molecular Pharmacology Highlighted Trainee Author for January 2026. Her research focuses on finding early warning signs of Alzheimer’s disease. 🔗 Read the research: https://doi.org/10.1016/j.molpha.2025.100088

Congrats to the 4 recipients of Trainee Challenge Awards, awarded through a partnership w/ ASPET and the PhRMA Foundation, who have been recognized for their work in rapidly emerging areas in drug discovery research. Their award-winning research is free to read and share: https://ow.ly/V5jw50XR9Ws 🧪

Modern antidiabetic drugs do more than lower sugar, they protect the heart and vessels. This review explains how. #PharmRev 🧪 https://ow.ly/nZLt50XMvsO

Last chance! PharmRev's Editor has selected the following article as free to read through December! We invite you to read this review that explores how marine-derived compounds are shaping the future of natural health products and modern pharmacology: https://ow.ly/8Jq150XBTGm 🧪

Neuropeptides fine-tune the brain’s noradrenergic centre. This review maps how they regulate the locus coeruleus to shape behaviour. #PharmRev Danai Riga 🧪 https://ow.ly/SrCq50XMrCq#PharmRev

Posttraumatic epilepsy remains untreatable. This review highlights new models and strategies for PTE prevention and therapy. #PharmRev #Epilepsy 🧪 https://ow.ly/EHRR50XMrre

EPAC proteins reshape blood vessels. This review dissects cAMP-driven vascular remodeling and its therapeutic implications. #PharmRev #science 🧪 https://pharmrev.aspetjournals.org/article/S0031-6997(25)07486-1/abstract

MolPharm's Editor-in-Chief has selected the following article as free-to-read through December 31, which unpacks the underlying mechanisms of nicotine addiction, offering valuable perspectives on receptor pharmacology and early dependence processes: https://ow.ly/9G3q50XBSRo 🧪

Reprogramming cells to heal organs, this review explores breakthroughs in cell and tissue reprogramming for regenerative drug discovery. #PharmRev 🧪 https://ow.ly/9KGW50XMnLp

The complement system is booming, 8 new drugs in 5 years! This review covers the biology, pathology, and therapeutic targeting of complement pathways. #PharmRev @neurocomplementlab.bsky.social 🧪 https://ow.ly/Tolg50XL5V5

Raeanne Lanphier, a 4th year PhD candidate, is the DMD Highlighted Trainee Author for December 2025. Her research focuses on understanding why a small number of patients develop unpredictable liver injury from the antibiotic sulfamethoxazole/trimethoprim: https://doi.org/10.1016/j.dmd.2025.100195.

DMD's Editor-in-Chief has selected the following article as free to read for the month of December, which introduces advanced ensemble modeling approaches for predicting drug-drug interactions involving CYP enzymes: https://dmd.aspetjournals.org/article/S0090-9556(25)09146-9/fulltext #science 🧪

📢 Hypoxia fuels tumor survival. This review from Gregg Semenza explores small-molecule inhibitors of HIF-1/2 as emerging cancer therapeutics. #PharmRev 🧪 https://ow.ly/jENZ50XJOVj

JPET is planning a collection titled “Gene and Cell-Based Therapeutics for Disorders of Maladaptive Neuroplasticity," profiling original research in all areas associated w/ gene and cell-based therapeutics for neurological disorders driven by maladaptive neuroplasticity: https://ow.ly/esRy50XJP0s 🧪

EGFR drives many cancers, but resistance remains a challenge. This review decodes EGFR biology and emerging strategies to overcome therapy resistance. #PharmRev #cancertherapy #science 🧪 https://ow.ly/IiMg50XHqHK

JPET's Editor-in-Chief has selected the following article as free to read for the month of December! We invite you to read and share this study, which sheds new light on how autophagy may help cells respond to targeted therapies: https://ow.ly/Vwpc50XBQyv 🧪

Targeting serotonin to treat neurodegeneration: this review explores how the serotonergic system could unlock new therapies for Alzheimer’s, Parkinson’s, and ALS. #PharmRev #Neuroscience #science 🧪 https://ow.ly/xK4z50XHqhf

Harlie McKelvey, a Neuroscience PhD candidate, is the JPET Highlighted Trainee Author for December 2025. Her research focuses on understanding how repeated, spontaneous opioid withdrawal affects overall sleep architecture and brain activity. ➡️ Read here: https://doi.org/10.1016/j.jpet.2025.103766.

📢 Read our Editor's Choice, "Molecular mechanisms of 10-butyl ether minocycline, a novel nonantibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders" https://jpet.aspetjournals.org/article/S0022-3565(25)40261-4/abstract 🧪

ASPET Discovery's Editor-in-Chief has selected this article for December's highlight, which unveils innovative approaches for studying protein interactions. We invite you to read the research and share it with your colleagues: https://ow.ly/eeoI50XBUgv 🧪

Pharmaceutical Metabolite Data Base (PharmMet DB) was created with metabolites from 1,114 drugs identified in human liver S9 fractions by LC-HRMS and compared to in silico predicted metabolites, offering a new resource for metabolite analyses and broad applications: https://ow.ly/kxB750XAGVx 🧪

Tri Do, PharmD, is the Molecular Pharmacology Highlighted Trainee Author for December 2025. His research focuses on how drugs interact with proteins in the heart that control electrical activity, specifically ion channels: https://doi.org/10.1016/j.molpha.2025.100086.

This comprehensive review explores how bile acid metabolism and signaling contribute to hepatocellular carcinoma (HCC) pathogenesis. Learn more in our Social Media Ambassador Choice from the most recent issue of Pharmacological Reviews. #science 🧪

Read our recent Editor's Choice in Molecular Pharmacology, and share the research with your colleagues: https://www.sciencedirect.com/science/article/abs/pii/S0026895X2515640X 🧪

📢 Reminder: join our webinar, today at 12 pm! Are you finishing your PhD or postdoctoral research? Will you be on the job market and want to pursue a career in academia or industry? Then join our Drug Metabolism and Disposition Career Panel for Trainees: https://ow.ly/IqYb50XAcGx #science 🧪

Dopamine doesn’t just drive reward; it guides our social lives. This review explores how dopamine regulates social behaviour across species. #PharmRev #Dopamine Nancy Padilla-Coreano Martínez-Rivera 🧪 https://ow.ly/hx0x50XARUX#PharmRev#Dopamine

Read the the Editor's Choice for the most recent issue of the Journal of Pharmacology and Experimental Therapeutics: An antifentanyl monoclonal antibody reverses fentanyl-induced apnea in pigs. #science 🧪 https://ow.ly/SZpJ50XAGp6#science

This special collection will celebrate the research showcased by attendees of the 5th Transatlantic ECI GPCR Symposium, a free online event to foster transatlantic knowledge exchange and collaborations within the GPCR community. Learn more and submit your work: https://ow.ly/Ffii50XxG1o 🧪

Make sure to check out our most recent collection in JPET. Clot Formation: Novel Regulators, Drugs & Targets: a special section highlighting today’s antithrombotic therapies and tomorrow’s breakthroughs. Explore the future of treatment: https://ow.ly/ywFY50XxFvm 🧪

📢 Check out this new call for papers from the Journal of Pharmacology and Experimental Therapeutics, and learn how to contribute your impactful research to this special collection! 🧪 https://ow.ly/TMJu50XxG7g

There's no better place than ASPET26 to present the most innovative science in pharmacology and experimental therapeutics! We welcome you and your latest research for inclusion at our 2026 Annual Meeting. Learn more about submitting an abstract: https://ow.ly/GWK750Xuh1z 🧪

Join us TODAY at 12 pm ET for an engaging workshop that demonstrates novel approaches to pharmacology education. Learn more: https://ow.ly/wgga50XmtRH 🧪 * This webinar is only for ASPET members. If you would like to learn more about membership options, please visit our website.

What's new in the Washington Update: NASEM’s recent workshop on researcher assessment highlights multi-level strategies to align assessment and incentives with research integrity, open science, and public impact. Read more: buff.ly/uFTRVc6

This collection will celebrate the research by attendees of the 5th Transatlantic ECI GPCR Symposium, organized for early-career investigators by early-career investigators to foster transatlantic knowledge exchange & collaborations within the GPCR community: www.aspet.org/aspet/news/n... 🧪

Junlong Chen, a 4th year PhD candidate, is the DMD Highlighted Trainee Author for November 2025. “I have successfully generated a small part of the human small intestine. These cells can be expanded and cryopreserved for long-term storage." ➡️ https://doi.org/10.1016/j.dmd.2025.100170

There are only a few days left to apply for ASPET's Editorial Fellowship Program, a one-year program for senior post-doctoral fellows and junior faculty members to build important skills as peer reviewers and editors. Learn more: https://ow.ly/Qgqi50XqBIc

ICYMI, all of the ASPET journals will have new covers in 2026! Learn more about the covers, and the scientists who designed them: https://ow.ly/zQuX50XouaM

Make sure to get your application in for ASPET's Editorial Fellowship Program, a one-year program for senior post-doctoral fellows and junior faculty members to build important skills as a peer reviewer and as an editor. 🧪 Applications due November 17! Learn more: https://ow.ly/mFn350XmNpR

Join us on Nov. 19 for an engaging workshop that demonstrates novel approaches to pharmacology education. Learn more: https://ow.ly/8aNf50XmtRG * This webinar is only for ASPET members. If you would like to learn more about membership options, please visit our website.

Syed Anees Ahmed, PhD, is the JPET Highlighted Trainee Author for November 2025. Understanding and blocking ferroptosis could help protect people whose medical treatments or conditions alter estrogen or perhaps other sex hormone levels: https://doi.org/10.1016/j.jpet.2025.103690.

📢 This special issue celebrates the top-tier research showcased by attendees of the 4th Transatlantic ECI GPCR Symposium, a free online event organized for early-career investigators by early-career investigators. Read their research: https://ow.ly/vtFr50XmNAu #science 🧪

Earlier this year, ASPET held a contest to design the covers for our five journals for 2026, and we're excited to share the winning covers with you! Learn more about the covers, and their designers, at: https://ow.ly/6wUk50XlWhL

New in the Journal of Pharmacology and Experimental Therapeutics (JPET)! Clot Formation: Novel Regulators, Drugs & Targets: a special section highlighting today’s antithrombotic therapies and tomorrow’s breakthroughs. Explore the future of treatment: https://ow.ly/HAmy50Xm01h 🧪#science

Join us for tomorrow's webinar featuring Drug Metabolism and Disposition authors discussing their published work and publication process. The webinar is perfect for junior researchers and aspiring authors in pharmacology. Learn more and register: https://ow.ly/JMi650XlLrW 🧪

Applications to become a 2026 ASPET Editorial Fellow are now open! 🧪 Those chosen for the program will have an in-depth opportunity to learn important elements of the editorial process. Learn more and apply: https://www.aspet.org/aspet/journals/aspet-editorial-fellowship-program #science

Important notice for ASPET members! 📢