🚨Thrilled our work is out in @NatureComm!🚨 Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs. Read the full paper: doi.org/10.1038/s414...

Cool new paper by Galmozzi et al.! www.nature.com/articles/s41... They show that bacterial chaperones bind regions of nascent proteins with exposed "unsatisfied residues" (segments missing key native contacts due to ongoing translation). A shared theme with our recent work on Native Fold Delay.

🚨New lab preprint!🚨 Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge. www.biorxiv.org/content/10.1...

A new @MolecularCell paper shows that bacterial sRNAs can bind within coding sequences and enhance protein activity without affecting mRNA levels, pointing towards a new mechanism of co-translational folding regulation! Could this be used as tool to induce translation pausing? 👀 #translation

Had a fantastic week at @embl.org to learn the ins and outs of ribosome profiling directly from some of the best in the field! Grateful to the amazing organisers, trainers, and fellow participants for such an enriching experience. #ProteinTranslation #EMBORiboProf

Very excited to share our new preprint together with @daniedaaboul.bsky.social, where we studied the gene regulatory code that hippocampal granule cells (GCs) use during synapse formation (1/n)

Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳ Read more here www.nature.com/articles/s41...