Susan Kilgas
@susankilgas.bsky.social
📤 102
📥 157
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Postdoc at Dana-Farber Cancer Institute in the Chowdhury lab | Interested in genome stability 🧬
reposted by
Susan Kilgas
Chowdhury Lab
about 1 month ago
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
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Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...
https://www.cell.com/cell-chemical-biology/abstract/S2451-9456(25)00232-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945625002326%3Fshowall%3Dtrue
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🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote:
@chowdhurylab.bsky.social
. Abstracts due Nov 23, 2025. 🔗 Sign up here:
www.grc.org/dna-damage-m...
about 2 months ago
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reposted by
Susan Kilgas
Stowers Institute
5 months ago
Thank you to
@chowdhurylab.bsky.social
(
@danafarber.bsky.social
) for joining us for a fantastic
#WednedsayLectureSeries
on "DNA repair mechanisms in the context of cell cycle with implication in
#cancer
." 🧬 Hosted by the Si Lab.
#SciSky
#ResearchSky
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reposted by
Susan Kilgas
Chowdhury Lab
5 months ago
Excited to share our latest publication, out in
@science.org
! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to
@michelleswift.bsky.social
and all authors!
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CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
https://www.science.org/doi/10.1126/science.adt3034
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