Francesca Chandler
@francescachandler.bsky.social
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Very happy to share the work from my PhD is out today in
@naturesmb.bsky.social
! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling:
www.nature.com/articles/s41...
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Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
https://www.nature.com/articles/s41594-025-01517-5
8 months ago
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reposted by
Francesca Chandler
Elton Zeqiraj
8 months ago
A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...
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Molecular Glues: drugging the undruggable
YouTube video by Phospho Biomedical Animation
https://youtu.be/wuFVeW6eCPg?si=HOMazUleWblDqieJ
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reposted by
Francesca Chandler
Elton Zeqiraj
8 months ago
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
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Very happy to share the work from my PhD is out today in
@naturesmb.bsky.social
! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling:
www.nature.com/articles/s41...
loading . . .
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
https://www.nature.com/articles/s41594-025-01517-5
8 months ago
0
16
3
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