Francesca Chandler
@francescachandler.bsky.social
📤 20
📥 39
📝 1
pinned post!
Very happy to share the work from my PhD is out today in
@naturesmb.bsky.social
! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling:
www.nature.com/articles/s41...
loading . . .
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
https://www.nature.com/articles/s41594-025-01517-5
10 months ago
0
16
3
reposted by
Francesca Chandler
Elton Zeqiraj
10 months ago
A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...
loading . . .
Molecular Glues: drugging the undruggable
YouTube video by Phospho Biomedical Animation
https://youtu.be/wuFVeW6eCPg?si=HOMazUleWblDqieJ
0
0
1
reposted by
Francesca Chandler
Elton Zeqiraj
10 months ago
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
loading . . .
5
51
20
Very happy to share the work from my PhD is out today in
@naturesmb.bsky.social
! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling:
www.nature.com/articles/s41...
loading . . .
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
https://www.nature.com/articles/s41594-025-01517-5
10 months ago
0
16
3
you reached the end!!
feeds!
log in
