Fritz Deufel (@chimicafritz.bsky.social)

Using racemization as a potential tool to prevent enzyme mutation-induced inhibition loss? Shout out to Kinga and everyone on these new metallo-β⁠-lactamase inhibitors. Looks like the easter bunny 🐰🥚 was busy over the holidays fighting antibiotic resistance 🤔. doi.org/10.1038/s420...

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Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors - Communications Chemistry Metallo-β-lactamases dismantle most β-lactam antibiotics and cause antibiotic resistance, however, no metallo-β-lactamase inhibitors are clinically available. Here, the authors report stereodynamicall... https://doi.org/10.1038/s42004-025-01510-5