🧪 A quick look behind the scenes. This 30 second clip condenses 25 minutes of prep for a metabolism assay on human brain cells ( #microglia ). Careful pipetting, clean technique, and lots of repetition. This is where the data begins. #lablife #neuroscience #braininury #science

It is estimated 1.4 million visit hospital every year in the UK with a #braininjury and 200,000 are admitted. tinyurl.com/3c2fvjxp

🧪 Neuron-derived extracellular vesicles carry tau and inflammation signals after impacts. We are validating these as potential risk markers for athletes and exploring how they may spread pathology. #EVs #Biomarkers #Science #BrainInjury

I'm hiring! Come and work with me at UCL to try and understand how the brain's blood vessels go wrong and promote dementia: www.ucl.ac.uk/work-at-ucl/...

😴 Deep sleep supports waste clearance and learning. Protect your sleep after a head injury with a steady schedule, daytime exercise, and low light before bed. #Sleep #TBI #Recovery #BrainInjury

⭐️UKABIF Summit 2025 - Sessions are now on our YouTube channel.⭐️ Watch here: youtube.com/@ukabif?si=-... #UKABIF #UKABIFSummit #ABICommunity #NeuroRehabilitation #BrainInjury

🧪 First look at our neuron derived EVs after head impact exposure in American football. ExoCheck neuronal panel shows at least two neuronal markers and an EV marker, with no cellular contamination. Image from today’s run. #EVs #TBI #AmericanFootball #Biomarkers #Science #BrainInjury

Listen to a new podcast about fetal monitoring and #braininjury open.spotify.com/episode/4Gx1...

🩸 New #TBI biomarker signal EV-GFAP in blood rises after TBI and relates to CT findings, flagging acute injury. Other EV markers were less helpful here, and plasma #GFAP still works well. We need more studies to learn when EVs add value for patients. #Biomarkers #EVs #BrainInjury #Science 🧪

Repetitive concussions can harm brain function even without overt cell loss 🧠 New work in mice shows that repeat hits activate microglia, which then eat away at excitatory synaptic inputs. Learning and memory suffer, despite no obvious cell death or bruising. #Concussion #TBI #BrainInjury #Science 🧪

A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative - The Lancet Neurology www.thelancet.com/journals/lan... #TBI #braininjury #Science 🧪

🧠It's important to understand how #CTE is different to other #brain diseases. In CTE, tau builds up around small blood vessels at the depths of cortical sulci, often in layers II and III. In #Alzheimers, tau tracks a different path and sits alongside amyloid plaques. #Science #BrainInjury🧪

🧠 Every #brain is different. With repetitive head impacts, wiring can be damaged and symptoms can appear. #CTE is diagnosed after death, but two clinical patterns are often discussed in life: a faster behavioural pattern and a slower #dementia like pattern. #Science #Braininjury🧪

🧪 Day in the lab. Isolating extracellular vesicles from plasma collected after #Americanfootball using size exclusion chromatography. Next I'm optimising a method called immunoprecipitation to further isolate neuron derived EVs. Excited to see what the data show. #TBI #LabLife #Science

#Microglia help explain why some people struggle cognitively after #TBI. Timing matters. Support early clean up, prevent long term overdrive, and protect synapses. Targeting microglia with the right therapy at the right time could change outcomes. #BrainInjury #Science 🧪

#Microglia also shape synapses, the connections that carry thoughts. After #TBI they may prune too much or release signals that destabilise these links, decreasing spine density and weakening brain circuits, especially in the hippocampus. #science #Braininjury 🧪

After #concussion, #inflammation aids clean up and injury resolution. If #microglia stay pro inflammatory for months or years, they keep releasing molecules that disrupt circuits, worsen blood #brain barrier leaks, and recruit more immune cells, prolonging symptoms. #BrainInjury #TBI #Science 🧪

Following #TBI, stress signals such as oxidative stress, calcium overload, and inflammatory signalling can push vulnerable neurons toward cell death. #Microglia may fuel this cascade, linking early injury to later memory issues. #Neuroscience #Braininjury #Science 🧪

Inflammation is a double-edged sword. Microglia patrol the brain. After #TBI they rush in, clear debris, and start repairs. Helpful inflammation can turn excessive, which then amplifies damage and impairs cognition. Balancing this response could be key. #Braininjury #Concussion #Science 🧪

🧠 After a head injury, thinking and memory can slip not only from the initial hit but also from how the brain’s immune cells called microglia respond over hours, days, and months. They can help OR they can prolong problems that affect cognition. #TBI #BrainInjury #Microglia

🧪 New study advances #TBI blood tests using single extracellular vesicles (EV) profiling. #Brain EVs captured from blood and read on a chip ID'd inflammatory signals in human and rodent models. Next we need larger cohorts and tau plus glial panels. #BrainInjury

🧠 After a #concussion, many people struggle to focus up close. That can mean headaches, blurry reading, and fatigue. A new study found that starting office-based vision therapy right away helped most people feel and focus better within 6 weeks, compared with waiting. #Braininjury #TBI

We are pleased to announce another PhD opportunity! Join Alexis Joannides for a PhD project on Imaging-Based AI Screening for Normal Pressure Hydrocephalus, funded through our Fellowship Programme. Deadline 14th January 2026. Interested: www.cam.ac.uk/jobs/phd-stu... Contact us for more details!

📰 Tina’s story shows how creativity can restore voice after brain injury. After a severe #TBI and coma, she learned BSL, earned Level 1, and helped build a deaf-aware community at Hughenden Gardens with Rose Ayling-Ellis’ project. Inspiring and practical. #BSL #BrainInjury #Concussion

Pleased to share a new podcast exploring concussion. hrc-braininjury.nihr.ac.uk/innovation-p... #ppi #scicomm #braininjury @braininjuryhrc.bsky.social

📣 @braininjuryhrc.bsky.social are gathering views on the unmet needs in brain injury care and ideas for tech that could improve outcomes. Be heard. Add your voice. Please share widely and repost. #BrainHealth #TBI #Concussion

Shane Christie’s story is heart breaking and urgent. The former Māori All Blacks and Highlanders player suffered severe symptoms after repeated head impacts and, after his death at 39, donated his brain to science. His legacy is a call for better care in rugby. #CTE #Rugby #Braininjury #Concussion

👏 Huge kudos to @braininjuryhrc.bsky.social for the Unmet Needs Directory. This needs more attention! 70 needs identified, 55 validated, mapping gaps from A&E to rehab and prevention. A brilliant launchpad for real solutions. hrc-braininjury.nihr.ac.uk/dun #BrainInjury #Research #neuroscience

As part of the Traumatic Brain Injury Model Systems Collaborative, a new guidance on communicating about brain injury was developed for clinicians, researchers, policymakers, and people with lived experience. Key message: Brain injury doesn't define a person. It's just one part of who they are.

New NIH funded work by @jon-cherry.bsky.social and team shows repeated head impacts can cause early neuron loss and inflammation in young athletes, years before classic CTE changes. This shifts the focus to cumulative exposure. www.nature.com/articles/s41... #CTE #TBI #Braininjury #concussion

The next 12 months we will be analysing the neuron derived extracellular vesicles from American footballers to test whether they contain any #TBI or #CTE related markers and if they induce #neurodegeneration like behaviour in cells. #braininjury #dementia #concussion

Head impacts in sport raise dementia risk for some people. We will study neuron derived extracellular vesicles in blood to learn how injury signals spread and how we can stop them. #TBI #CTE #Dementia #EVs #Neuroscience

🎉 First day on a pilot grant with @alzheimersresearchuk.org, supported by Wendy Noble and team. Project: Linking Head Trauma to Dementia: the role of neuron derived extracellular vesicles. Thank you for the support. I cannot wait to get started. More posts to follow daily. #ARUK #TBI #Dementia #EVs

Back after two months away for paternity leave and surgery recovery. Grateful for the time and support. Many student athletes do not get this. They feel pressure to study or play through concussion or risk falling behind. That pressure delays recovery. Put brain health first. #Concussion #TBI

👶 I am taking a brief break from Bluesky during paternity leave as we welcome our second child. I look forward to returning and sharing more about #braininjury when life settles. Thank you for the support. #FamilyTime #BrainHealth

🧠🌍 Happy #WorldBrainDay! A #braininjury can happen to anyone at any time & its impacts are life-changing. We’ve developed a Clinical Practice Guideline & Care Pathways to support consistent, evidence-based brain injury care: 🔗 kite-uhn.com/brain-injury... 🔗 www.neurotraumapathways.ca

Why GRAS matters for #concussion 📈 GRAS = Graduated Return to Activity and Sport. Six light-exercise stages over at least 21 days. Slow steps beat total bed rest and cut set-backs. #TBI #BrainInjury

🧠 You don’t need a direct hit to the head to suffer a #concussion. A heavy body blow, whiplash fall, or blast wave can whip the brain inside the skull and cause the same injury. Watch for symptoms after any big impact. #Braininjury #TBI

✅ True! Brain injuries are common among survivors of #IntimatePartnerViolence (up to 92% of all IPV cases) because the head, face, & neck are areas most likely to be injured in an assault. Check out the link below for more info on #braininjury and IPV: 🔗 www.neurotraumapathways.ca/intimate-par...

What is known about the mechanisms of #CTE? 🔬 Each impact twists axons, leaks tau, and sparks inflammation. Misfolded tau spreads from cortex to deeper regions, killing neurons and glia. Years later this cascade drives the symptoms we call CTE. 🧠 #TBI #BrainInjury #Concussion

How can reduce the occurrence of CTE? 🛡 Limit head impact forces in training, teach safe technique, strengthen necks, enforce strict return to play rules (with quantifiable data), and track exposure. Fewer knocks today mean healthier brains tomorrow. #TBI #CTE #BrainInjury

How big is the risk of CTE? 🧠 In donated brains, 50–90% of former pro American-football players. These samples come from families who suspected problems, so the true prevalence across all athletes is still unknown. We need large, unbiased studies to find the real numbers. #CTE #BrainInjury #science

Who is at risk of CTE? 🏈 Athletes in contact sports, military personnel, boxers, and anyone with long years of repetitive head knocks, even if many were called mild. More hits and less recovery time mean higher danger. #CTE #TBI #BrainInjury

What is CTE? 🧠 Chronic Traumatic Encephalopathy is a progressive brain disease linked to repeated head impacts. It brings memory loss, mood change, and movement problems years after the exposure to brain injuries. #CTE #TBI #BrainInjury

What happens when you have a #concussion? 🧠 One month and beyond 📉 Most people improve, but 10–20 % face lingering symptoms. 📊 Tracking mood, sleep, and cognition helps spot persistent issues early. Lifestyle choices, fitness, social contact, learning, keep brain ageing at bay. #BrainInjury #TBI

What happens when you have a #concussion? 🧠 Weeks 1–4: Rewiring and plasticity 🧬 Synapses reorganise, new pathways strengthen with practice. 🏃 Structured aerobic exercise boosts blood flow and growth factors. Sleep quality helps memory and mood gains. #braininjury

What happens when you have a #concussion?🧠 Days 1–7 Repair and vulnerability 🔄 #Glia clear debris and begin repair, but the #brain will struggle to use sugar 🤕 Symptoms may peak here, headaches, fog, mood shifts. Gentle activity, neck and balance checks, and nutrition aid recovery. #Braininjury #TBI

What happens when you have a #concussion? 🧠 Hours 1–24: The metabolic crisis 🧠 Cells switch to emergency mode, increasing glucose consumption. ⚠️ Inflammation starts, ion balance disrupted, risk of further damage. Hydration, monitored sleep, & minimal stimulation support early stability #braininjury

What happens when you have a #concussion? 🧠 Zero to 60 minutes: The impact zone 💥 Microscopic axon stretching, ionic storm, and sudden energy demand. 🩸 Blood flow dips, then surges, causing a brief metabolic mismatch. Early rest and removal from play are critical in this golden hour. #BrainInjury

🤝 Caregivers of #TBI survivors risk burnout and depression. Peer groups, respite programmes, and financial guidance help families stay strong alongside the injured person. Care for carers too. #CaregiverSupport #BrainInjury #MentalHealth