I decided to try out blogging! My first post is a reflection of my time on science Twitter and why I decided to start blogging. I'm going to give Bluesky a second chance, but It's nice to have a space for casual long-form writing ryanzfriedman.com/2025/09/06/s...

My thesis work on active machine learning to model regulatory DNA is now out in Cell Systems! We answer the question: When you can synthesize any DNA sequence you want, how do you decide which ones are worth testing? www.sciencedirect.com/science/arti...

We substantially revised our active learning manuscript. A brief summary of what's new. TLDR: several new analyses, benchmarking w a 2nd MPRA dataset, and a refocused argument on active learning to leverage the capacity of MPRAs to generate large datasets. www.biorxiv.org/content/10.1... 1/8 🧬🔄

A project I contributed to during grad school is now up at PLoS Comp Bio! We used the MAVE-NN package by @jbkinney.bsky.social's group to learn about the behavior of synthetic regulatory elements 🧬🔄 Keep an eye on @genologos.bsky.social's Twitter for more details. journals.plos.org/ploscompbiol...

I want to reorganize my @paperpile.bsky.social. I have folders covering broad topics with very few subfolders. Tags are for different manuscripts. Is there anyone in genomics 🖥️🧬 who wants to share how they organize their reference managers? I'm looking for more meaningful and detailed categories.

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I've had several software engineers ask me recently about transitioning into genomics/comp bio from tech. I never know what to say -- everyone I know in the field in industry went to school for biology/comp bio. Anyone have any suggestions, either of what to say or concrete resources to provide? 🧬🖥️

“The initial data leak was… 1 million lines of data for Ashkenazi people.” “The information… includes full names, usernames, profile photos, sex, date of birth, genetic ancestry results, and geographical location.” Well, that’s surely not going to be a fucking problem. (sarcastically) 🧪

I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"

Hello, world! I'm a computational biology postdoc at UW in Seattle interested in genomics 🖥️ 🧬, gene regulation 🧬 🔄, machine learning, data viz, and zebrafish 🐟 #DevBio. Also enjoy emo/punk music, sci-fi books, cooking, and gaming! #LGBTQSTEM 🏳️‍🌈 #HiSciSky