@labwyllie.bsky.social
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Delighted our latest paper is now published in Science Translational Medicine. Fantastic collab with Dr Avninder Bhambra and his team. Our studies reveal promising quinazolines selectively target KRS in T. cruzi.
www.science.org/doi/10.1126/...
@dundee.ac.uk
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Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease
Quinazolines targeting Trypanosoma cruzi lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
https://www.science.org/doi/10.1126/scitranslmed.adu4564
6 months ago
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Fantastic paper from MoA group alumni Richard Wall and colleagues 🙌
www.nature.com/articles/s41...
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Targeting de novo purine biosynthesis for tuberculosis treatment - Nature
The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.
https://www.nature.com/articles/s41586-025-09177-7
7 months ago
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New paper alert! Enjoy!
pubs.acs.org/doi/10.1021/...
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The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b
Chemotherapy remains a key component of the arsenal of tools to fight malaria. Specifically, new drugs with diverse mechanism(s) of action are required to combat existing drug resistance. Here, we des...
https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00259
7 months ago
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Hello Blue-sky! Delighted to be on an inclusive and well run platform!
9 months ago
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