Stefan Oberlin
@chnebster.bsky.social
📤 13
📥 40
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A project from my postdoc in the McManus lab
@mcmanuslab.bsky.social
at UCSF
@ucsfdc.bsky.social
is out today 🎉 For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell. We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
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Multiplexed perturbation enables scalable pooled screens - Nature Methods
This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.
https://www.nature.com/articles/s41592-026-03095-w?utm_medium=organic_social&utm_source=partner&utm_content=null&utm_term=null&utm_campaign=CONR_JRNLS_LYLT_GL_PJNL_06PJ3_ARTPROMTK
6 days ago
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