What if controlled disease doesn’t mean a quiet immune system? “We learned that even when HIV is controlled, inflammation persists — and that persistent inflammation is what drives many diseases of aging.” – Alan Landay #Longevity #AgingScience #Immunology

What if the biology of aging is written in immune activity? This clip from Episode 20 of Decoding Longevity introduces a conversation on chronic inflammation, immune health, and biological aging. #Longevity #AgingScience #Immunology

What if the roots of modern longevity science were uncovered in HIV immunology? In Episode 20 of Decoding Longevity, we explore how immune activation, chronic inflammation, and biological aging intersect.

New episode out 🎙️ We explore how immune activation and chronic inflammation shape biological aging — from gut health to future longevity interventions. Listen here: Spotify → open.spotify.com/episode/5Jzn... YouTube → youtu.be/GTGnEFaBhwA?... Apple Podcasts → podcasts.apple.com/tr/podcast/i...

Understanding longevity progress requires context, not just discoveries. 🎙️ In Episode 19 of Decoding Longevity, Dr. Karl Pfleger explains how tracking aging biotech by mechanisms of aging reveals what’s really changing. 🟢 open.spotify.com/episode/4j9E... 🔴 youtu.be/57sU8zGs_xo?...

What if the real shift in longevity science is moving from slowing aging to repairing its damage? 🎙️ Episode 19 of Decoding Longevity is now live. With Dr. Karl Pfleger on aging biotech, rejuvenation, and the future of the field. 🟢 open.spotify.com/episode/4j9E... 🔴 youtu.be/57sU8zGs_xo?...

What if breakthroughs in longevity don’t come from single discoveries, but from ecosystems built across science, capital, and community? 🎙️ Episode 19 of Decoding Longevity features Dr. Karl Pfleger on aging biotech, rejuvenation, and how progress actually happens.

What if progress in longevity isn’t limited by ideas — but by how we measure them? 🎙️ Episode 19 of Decoding Longevity is now live. A thoughtful conversation with Dr. Karl Pfleger on aging biotech, rejuvenation, biomarkers, and the ecosystem shaping longevity science.

We’re starting the new year of Decoding Longevity with Dr. Karl Pfleger. From aging biotech and rejuvenation strategies to investment realities and ecosystem building, this episode explores what it takes to move longevity science forward. 🎧 Episode 19 releases tomorrow.

What if longevity science included something as old as humanity itself—rituals, rhythm, and shared energy? In Ep18, Tina Woods introduces the idea of a “Longevity Rave,” highlighting how connection and movement support healthy aging.

Scientists now say loneliness may shorten lifespan more than smoking. So what does that mean for the future of aging? In Episode 18, we sit down with Tina Woods to explore how cities, social ties, community design, and exposome data shape health across a lifetime.

What if the key to healthy longevity isn’t only in our DNA — but in the cities and communities we live in? 🌍 In Episode 18, we talk with Tina Woods about the Exposome Revolution and how our environments shape how we age.

“Longevity goes far beyond bioscience — it shapes policy, cities, design, and the way we live.” — Tina Woods 🎙️ Episode 18 is officially LIVE! We dive deep into the exposome, longevity ecosystems, and how environments influence aging.

What if longevity isn’t shaped only by genetics — but by the city you live in, the air you breathe, the food you eat, the community around you? Tomorrow we release our conversation with Tina Woods on the Human Exposome Project. Episode drops TOMORROW. Don’t miss it #Longevity #Exposome #HealthyAging

Could stem cells unlock a new era of regenerative medicine? 🔬 In Episode 17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to discuss how tapping into our body’s earliest blueprint might one day reset aging itself.

What if the key to longevity lies in the earliest stem cells — ones that can rejuvenate tissues without ethical barriers? 🌿 In Ep.17 of Decoding Longevity, Yuta Lee joins Raghav Sehgal & Macsue Jacques to explore a new era of regenerative medicine.

Tomorrow’s episode dives into one of the most exciting frontiers in longevity — regenerative medicine. 🌱 Hosts Raghav Sehgal & Macsue Jacques chat with Yuta Lee (Accelerated Biosciences) about pioneering pluripotent stem cells that could redefine aging itself. 🎧 Episode 17 out tomorrow!

“You don’t need any of this oxidized cholesterol in your body.” Dr. Matthew O’Connor explains how 7-ketocholesterol — a toxic, oxidized form — drives vascular aging. 🎧 Ep16 out now! 🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...

We’ve been treating cholesterol for decades — but 7-ketocholesterol is far more toxic than we realized. 🎧 New Decoding Longevity episode out now! Ep16: Targeting 7-Ketocholesterol in Atherosclerosis 🔗 Spotify: open.spotify.com/episode/1ctI... | YouTube: youtu.be/EVhx11YavTk?...

What if cardiovascular aging could be reversed? 🧬 In Episode 16 of Decoding Longevity, Matthew “Oki” O’Connor explains how targeting 7-ketocholesterol — a toxic oxidized cholesterol — might be the key to tackling atherosclerosis at its root. 🎙️ #Longevity #AgingResearch #CardiovascularHealth

🎙️ Episode 16 is out today! What if cardiovascular aging could actually be reversed? 🫀 In today’s episode of Decoding Longevity, Matthew “Oki” O’Connor joins Raghav Sehgal and Macsue Jacques to explore how targeting 7-ketocholesterol could reshape heart health. #Longevity

New episode drops tomorrow! 🎙️ Join Raghav Sehgal and Macsue Jacques in conversation with Matthew “Oki” O’Connor on how clearing 7-ketocholesterol — a toxic oxidized lipid — could reverse plaque buildup and change how we treat cardiovascular aging. #Longevity #Atherosclerosis #HealthyAging

“Longevity should be part of basic healthcare, not a privilege.” 🌍 In Episode 15 of Decoding Longevity, Jasmine Smith (Rejuve.AI) joins hosts Raghav Sehgal & Macsue Jacques to explore how AI and decentralized science make longevity more inclusive. #Longevity #AI #DeSci #Healthspan

What if the future of science wasn’t locked in labs, but built on a global network of people sharing data and accelerating discoveries in real time? 🌍 That’s the vision of decentralized science (DeSci) — and it’s transforming how we study aging and longevity.

“Decentralized science is about breaking down silos and creating a global network where everyone can contribute to longevity research.” 🌍🧬 In Decoding Longevity Ep.15, Raghav Sehgal & Macsue Jacques explore how Rejuve.AI’s vision of DeSci is changing the way we study aging.

Beyond DNA: the future of aging research lies in multi-omics approaches. 🌍 In Ep.14 of Decoding Longevity, host Macsue Jacques and Prof. Brian Kennedy discuss how proteomics, lipidomics, and other biomarkers can provide a holistic view of aging. #Longevity #HealthyAging #MultiOmics #BrianKennedy

“Methylation clocks are powerful, but in the clinic, changing lives takes more.” 🧬 In Decoding Longevity Ep.14, Dr. Macsue Jacques and Prof. Brian Kennedy explore: – Why methylation has limits in clinical use – How biomarkers must evolve for real-world impact – The future of aging diagnostics

Every biological clock tells a different story. 🕰️ DNA methylation, proteomics, lipidomics — each has strengths, weaknesses, and unique insights into aging.

“What if we could measure how fast we’re aging—AND test if lifestyle changes could slow it down?” In Ep. #14 of Decoding Longevity, Dr. Macsue Jacques hosts Prof. Brian Kennedy for a deep dive into epigenetic clocks, interventions, and the future of healthy aging.

🎙️ New episode out today! On Decoding Longevity Ep. #14, Dr. Macsue Jacques welcomes Prof. Brian Kennedy for a fascinating discussion on: ✨ Biological aging clocks that predict mortality ✨ Why modifiable clinical features matter ✨ How science is transforming our approach to longevity

🚨 New episode dropped! 🚨 “If we are calling ourselves aging researchers and we haven’t defined aging, I think there is a lack. We need a definition that we can operationalize.” — Prof. Andrea B. Maier, from National University of Singapore

What if precision medicine applied not only to disease, but to aging itself? 🧬 In Ep13 of Decoding Longevity, Prof. Andrea B. Maier joins hosts Raghav Sehgal & Macsue Jacques to discuss how personalized biology could change the way we age. #Longevity #PrecisionMedicine

🚨 Our latest episode just dropped today! 🚨 “First we diagnose, then we treat. The same should apply to aging.” — Prof. Andrea B. Maier

The future of aging isn’t generic—it’s precision geromedicine. 🌍✨ In Ep13 of Decoding Longevity, Prof. Andrea B. Maier (National University of Singapore) joins Raghav Sehgal & Macsue Jacques to explore how biomarkers, genetics & multi-organ data shape interventions built for your biology.

Clocks estimate age. But what if they could reveal discoveries? 🧬 EnsembleAge detects stress, rejuvenation & novel mechanisms, helping translate aging science into clinics. 🎧 Ep. 12 of Decoding Longevity with Dr. Amin Hagani Hosts: Raghav Sehgal & Macsue Jacques #Longevity #AgingResearch

🚀 New Episode! Aging isn’t one-dimensional—it’s chemical, genetic, environmental & more. In Ep. 12, Dr. Amin Haghani joins hosts @rvsehgal.bsky.social & Macsue Jacques to share how EnsembleAge captures the full story of aging. 🎧 Listen here: open.spotify.com/episode/0U0z... #Longevity #AgingScience

What if we could detect subtle biological changes before symptoms appear? 🧬

New episode out now! 🚨 In Ep.12 of Decoding Longevity, Dr. Amin Haghani joins hosts Raghav Sehgal & Macsue Jacques to discuss EnsembleAge—a new generation of epigenetic clocks reshaping how we measure aging, stress, and rejuvenation. 🎧 Watch/Listen now! #Longevity #AgingScience #Epigenetics

🎙️ Tomorrow we drop a new episode of Decoding Longevity! Our guest Dr. Amin Haghani takes us inside the development of EnsembleAge and its impact on aging research. We’re grateful for his insights and can’t wait to share this conversation with you. ✨ Stay tuned — Episode 12 is almost here!

🧬 Whole-genome CRISPR screening in neurons = a new frontier for brain aging research. Yes, that means knocking out every single gene—one by one. 🚀 Episode 11 of Decoding Longevity is out now!

Episode 11 of Decoding Longevity is live! 🚀 This week we explore how whole-genome CRISPR screens in neurons are unlocking new insights into aging, brain health & neurodegeneration. 🧬 Hosts: @rvsehgal.bsky.social & Macsue Jacques 🎧Listen here: open.spotify.com/episode/6IvA... #Longevity #CRISPR

Could we slow or accelerate brain aging with a single molecular switch? In Decoding Longevity, Dr. Macsue Jacques & Dr. Raghav Sehgal speak with Dr. Nathalie Saurat about the emerging role of neddylation in Alzheimer’s research 🎙 Full episode out now #BrainHealth #LongevityScience #Neurodegeneration

🎙 Decoding Longevity Ep11 is here! Hosts Dr. Macsue Jacques & Dr. Raghav Sehgal talk with Dr. Nathalie Saurat about neddylation—a molecular switch that could change how we study and prevent Alzheimer’s. Now streaming on Spotify & YouTube. #BrainHealth #LongevityScience #Neurodegeneration

Coming tomorrow on Decoding Longevity: A deep dive into neddylation, the hidden molecular switch behind neuronal aging. With guest Dr. Nathalie Saurat, we explore how aging can be programmed into neurons to better understand and combat late-onset neurodegenerative diseases like Alzheimer’s.

Is aging really just a slow fade—or a cellular rebellion in disguise? 🧬 In Ep10 of Decoding Longevity, we dive into the science of senescence and how some aging cells could be rescued. 🎧 Watch the full episode now on Spotify & YouTube! #Longevity #Senolytics

New episode of Decoding Longevity lands tomorrow! 🧬 We talk to Dr. Iman Azimi about senescent cells, why they aren't all alike, and how his study might reshape how we approach aging with drugs like rapamycin. Hosts: @rvsehgal.bsky.social & Macsue Jacques #Senolytics #Longevity

Everyone’s asking: “When will biomarkers be ready for the clinic?” But what we need is proof they work in the real world. Catch Ep9 of Decoding Longevity with Chiara Herzog, Raghav Sehgal & Macsue Jacques. #Aging #Biotech #Longevity #DecodingLongevity

Everyone’s asking: “When will biomarkers be ready for the clinic?” But what we need is proof they work in the real world. Catch Ep9 of Decoding Longevity with Chiara Herzog, Raghav Sehgal & Macsue Jacques. #Aging #Biotech #Longevity #DecodingLongevity

🎧 New episode of Decoding Longevity is out! "We don’t just need more data—we need better, shared, and regulated data." Chiara Herzog joins us to talk about the messy reality of turning aging science into clinical tools. Hosted by Raghav Sehgal and Macsue Jacques

We can clock your biological age with just a few drops of blood. So why isn’t your doctor using it? Because translating science into clinical tools is messy. Really messy. New @DecodingLongev episode with @chiaraherzog.bsky.social 🎧 Ep9: The Biomarkers of Aging Bottleneck