Interesting👍

TF dosage can expand regulatory scope and yield qualitatively different differentiation outcomes.

Machine learning + single cell omics + morphological phenotyping = molecular basis underlying morphological variations👍

The integration of DARLIN system with spatial transcriptomics👍

Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders | Science www.science.org/doi/10.1126/...

Dubito, ergo Cogito, ergo sum.

EiTiX undergoes neurulation and heart development. MGZ: This unified model recapitulates developmental events from embryonic day 5.5 to 8.5 (gastrulation; formation of AP axis, brain, and a beating heart structure; and the development of extraembryonic tissues, including yolk sac and chorion).

Step-wise induction of totipotent-like cell-based embryo model. J Xu: It recapitulates key developmental milestones, including zygotic genome activation in 2-cell embryos, the formation of blastocysts and the subsequent development into post-implantation egg cylinders.

Totipotent like TBLCs mimic early embryogenesis. P Du: single TBLCs underwent expansion, compaction, and polarization to efficiently generate blastocyst-like structures and even post-implantation egg-cylinder-like structures.

👍👍👍 induced assemble+ Ex Utero culture lead to advanced embryogenesis. JH: Post-gastrulation stages of development with organ progenitors and complex extra-embryonic compartments are achieved ex utero entirely from assembled naive mouse embryonic stem cells.

Moving forward! induced ETX. MGZ: iETX embryos establish a robust anterior signaling center that migrates unilaterally to break embryo symmetry.

It takes three to initiate gastrulation. MGZ: Three stem cell types self-assemble in vitro into gastrulating embryo-like structures undertaking spatiotemporal events of the gastrulating mammalian embryo.

👍👍👍 Landmark work in the embryo model field. MZG: establishing a close cross-talk between emb and exe in a 3D ECM scaffold is necessary and sufficient for the self-assembly.

Very happy to be part of this wonderful team! 😀😀😀

Meet our Preprint Editors We are pleased to welcome Xianfa Yang to our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles. journals.biologists.com/dev/pages/pr...

Very nice work! Inhibition of Hippo signaling, activation of Wnt signaling and TGFbeta signaling give rise to MTSC. J Zhang: Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state

Very nice work!👍 WQ Liu: Integration of BPSCs with PrE induction system enables high-efficiency generation of E8.5-stage embryo models. www.nature.com/articles/s41...

Yu: Despite differing views on the underlying mechanism, both studies converged on a shared conclusion: improved induction of extraembryonic lineages is essential for enhancing the developmental potential of SCBEMs

Many years later, as he faced the firing squad, Colonel Aureliano Buendía was to remember that distant afternoon when his father took him to discover ice.

Nice work to explore cellular fitness and intercellular competition.

Invictus

风来时，爷爷没有躲避，尽管风把我们车上的草刮的只剩下最后一颗，我们的车还在，我们就像钉在大坝上一样，没有前进，但是也没有倒退。我觉得从这个意义来讲，我们胜利了。 - 《不被大风吹倒》

Amazing! www.sciencedirect.com/science/arti...

Primed chromatin signatures at HOX loci enables regeneration and also facilitate the susceptibility to gliomagenesis.🫡 www.nature.com/articles/s41...

Pluripotency factors premarked cell-type-restricted enhancers also exist in human ES cells👍👍👍

Really inspiring work! 🫡 There may exist alternative explanation beyond the signal responses to IHH signaling for the reason why no cilia formed in XEN and TE cells. 🤔

Cross-species comparison revealed that only mouse initiate BMP signaling in trophectoderm lineage (extraembryonic ectoderm), while other mammals, such as Pig, rabbit, and sheep, generate BMP signaling from the hypoblast.

SEM models in livestock👍👍👍 Why, how and what for ? www.biorxiv.org/content/10.6...

Deeplearning captures unseen sex features in early human embryos. Amazing!! royalsocietypublishing.org/rsob/article...

So differentation could be a aging-related features amplifier? www.sciencedirect.com/science/arti...

Science from Six years ago: Generation of human endothelium in Etv2 mutated Pig embryos. How can the human differentiation speed be accelerated and what about the he functional fidelity of these Endo cells? www.nature.com/articles/s41...

Bravo! construction of testicular organoid, the co-culture of testicular niche and PGCLCs, and the generation of viable progeny www.science.org/doi/full/10....

To what extent can we reconstruct the embryo?

A new day to say goodbye and hi

Single-cell analysis, ectoderm patterning, morphogen gradient, signaling activity www.biorxiv.org/content/10.6...

Transposable element reactivation on ecDNA rdcu.be/eVm9q

A shifting of the perspective brings new insights! GENE BODY also contributes! Functional maps of a genomic locus reveal confinement of an enhancer by its target gene | Science www.science.org/doi/10.1126/...

Nice work! 👍👍👍 Capturing trophectoderm-like stem cells enables step-wisely remodeling of placental development www.biorxiv.org/content/10.1...

Thrilled to share our most recent work concerning the mechanistic study of developmental enhancers. Cis or trans may be a spatial-temporal choice 😁😁😁 advanced.onlinelibrary.wiley.com/doi/10.1002/...

Very nice work! Gastruloids set up the cellular basis for prospective functional celltypes. In-depth molecular survey determining the exact similarity or translational application validating the functionality may be the next steps. | Science www.science.org/doi/full/10....

Heterogeneous intrinsic features for superenhancer, balance between details and landscape. Quote: ‘The partitioning of sub-units within SEs as constitutively active (PU) or decommissioned (DM) proposes a mechanism by preserving pluripotency as cells prepare for subsequent differentiation.’

Thrilled to share our newly published work about how primitive endoderm fate is regulated by a lncRNA gene (Gm26793)-mediated inter-chromosomal interaction. P.S. Biology is like magic. Keep smart and stay alert to strike the gold. Unknown but crucial things ahead!

The offspring from GF mothers were highly susceptible to metabolic syndrome characterized by an exacerbation of obesity and glucose intolerance in association with reduced energy expenditure upon high-fat diet consumption during adulthood.

@mbekatoros.bsky.social τυχαίο μένσιον! 👇 Dari Zuron “Working on yourself” #art #artgr

Very impressive work! 👍👍👍 Remaining questions: How do initial cell states (naive vs. primed) exhibit differential responsiveness to the same signal stimuli? How does certain additional extrinsic signals (Nodal signaling here) eliminate the differences? Signaling principles and cell fate choice

Just see a post about the Great Lady- Ms Lu on the day of China Female football team win the Asian champion. Salute to the history

The off target effects is never a random phenomenon and also not be specific for epigenetic editing at age-associated CpGs for the bystander effect. Worth further studies!

DNA replication time sequencing. Pluripotency factors play a role in the firing efficiency of mESCs. What about the cell differentiation process? 2025.01.07.631761v1

Really smart design of leveraging polyA-tailed transposome to unify the molecular approach for spatial epigenome, transcriptome and cell lineages👍 www.pnas.org/doi/10.1073/...

Human-specific LTR5Hs regulation of a primate-specific gene is essential for blastoid formation. Definitive study!!! www.biorxiv.org/content/10.1...