Society for Acute Medicine (@acutemedicine.bsky.social)

Development and Validation of a Comorbidity Index to Predict In-hospital Mortality Risk for Stevens-Johnson Syndrome - Acute Medicine Journal Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of high-mortality severe drug reactions. This study aimed to develop an in-hospital mortality risk calculator for SJS based on comorbidities for early risk prediction. Methods: SJS/TEN patients were identified in National/Nationwide Inpatient Sample between Q4 2015-2020. Weight for each comorbidity was determined from a multivariable logistic regression to develop SJS Index. Results: SJS Index had good discrimination power (c-statistic=0.704) and was well-calibrated (Brier score=0.049). SJS index had significantly better discriminative power than Elixhauser Comorbidity Index (p-value=0.001). SJS Index has good applicability in SJS-TEN and TEN. After adjusting for demographics, SJS Index had improved performance in all groups. Conclusions: SJS Index effectively discriminates and predicts in-hospital mortality in SJS/TEN. https://acutemedjournal.co.uk/development-and-validation-of-a-comorbidity-index-to-predict-in-hospital-mortality-risk-for-stevens-johnson-syndrome/#article-text