Mohiuddin et al.’s systematic review has revealed little evidence for combination pharmacotherapy to treat chronic pelvic pain. Future high-quality trials are needed in this area. Learn more in #PainReports bit.ly/45AI7OY

Conroy et al. find that modeling of baseline factors did not predict successful initiation or maintenance of buprenorphine treatment for chronic pain in enriched enrollment randomized withdrawal studies from the FDA database. Learn more in #PainReports bit.ly/4oGSXvD

Nissen et al. find that the CHIPPS behavioral assessment was more effective than skin conductance algesimetry for pain detection in postsurgical infants and combining both methods may improve pain management. Learn more in #PainReports bit.ly/4oLK8kn

Romero-Serrano et al. find that pain management using a closed-loop spinal cord stimulation in a patient with an implantable cardioverter defibrillator can be safely performed without interference between the devices. Learn more in #PainReports #PainAwarenessMonth bit.ly/45Mbv5d

Do you have any thoughts on medical jurisprudence in the context of chronic musculoskeletal nociplastic pain? Check out Editor Allan Basbaum’s comments on the article published by Assis et al. in @painreports.bsky.social bit.ly/4mJKF52 #PRF #EditorsPick #PainAwarenessMonth

Nickerson et al. find that novel adaptive recall-by-genotype study demonstrated no effect of TRPA1 putative gain-of-function polymorphism on sensory function in naïve or cinnamaldehyde-sensitized skin. Learn more in #PainReports #PainAwarenessMonth bit.ly/4oKlikM

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca#PainReports#PainAwarenessMonth

Navarro et al.’s exploratory clinical trial analyses suggest that fibromyalgia pain is more intense in the evening. This pattern should be studied further, particularly when investigating fibromyalgia interventions. Learn more in #PainReports #PainAwarenessMonth bit.ly/4p4carB

A nationwide cross-sectional study 2025 by Hellmann et al. found more than one-fourth affected by chronic noncancer pain related mainly to high-impact chronic noncancer pain in 8,643 adult Danes. Learn more in #PainReports bit.ly/45LIC9i

Gonzales et al. find that natural speech characteristics can be used as biomarkers of pain and are linked to baseline pain sensitivity, and speech production reliably reduces pain intensity. Learn more in #PainReports bit.ly/4oNrOat

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

Goncalves et al. compared a cohort of de novo post-COVID-19 pain to a chronic pain cohort with knee osteoarthritis and investigated opioid receptor Mu 1 polymorphisms. Learn more in #PainReports bit.ly/3Ve2xIQ

Tseng et al. used mouse models to determine that the conditional overexpression of contactin-associated protein-like 2 in DRG neurons does not affect neuropathic pain behaviors but reduces sensitivity to capsaicin. Learn more in #PainReports bit.ly/419BqSJ

Tseng et al. used mouse models to determine that the conditional overexpression of contactin-associated protein-like 2 in DRG neurons does not affect neuropathic pain behaviors but reduces sensitivity to capsaicin. Learn more in #PainReports bit.ly/45qn5Tp

Motohashi et al. demonstrate that inflammation-related, pain-related, and emotion-related signaling remain elevated in both the peripheral and central nervous systems, accompanied by ongoing stress responsiveness. Learn more in #PainReports bit.ly/3JhZRYg

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

Adeno-associated virus-mediated expression of multiple pronociceptive Nav peptide inhibitory peptide aptamer NaViPA1 in peripheral sensory neurons attenuates stimulated and spontaneous pain in osteoarthritis. Learn more in Shin et al. #PainReports bit.ly/4oQM6Qy

Kang et al. find that brief pain inventory numerical rating score greater than 1.5 (worst pain), 0.5 (average pain), and 0.8 (pain interference) defines unacceptable persistent pain after breast cancer surgery. Learn more in #PainReports bit.ly/40SOqfA

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

Dutkiewicz et al. identified 81 quality indicators for opioid stewardship, which can be applied to develop future standards. Learn more in #PainReports bit.ly/4ovezeA

For people with an acute episode of low back pain, Chang et al. find that processing of non-noxious sensory inputs changed over time differentiated 6-month pain, but not disability outcome. Learn more in #PainReports bit.ly/3FoaRld

Can your voice reveal how much pain you’re in? Our new study with #UniMelb published in @painreports.bsky.social shows speech can serve as marker of acute pain and speaking might help reduce it. 🤕 🔗 Read more: redenlab.com/what-can-spe...

Great to have this published in @painreports.bsky.social doi.org/10.1097/PR9.... Congratulation Stephanie Smith and team. I was happy to provide further CAP-RA data for analyses as part of the SOCRATES data collection funded by @researchwales.bsky.social @ctrcardiffuni.bsky.social

Kumar et al. find that patients with migraine without aura exhibit heightened cortisol responses and gene expression changes after a neuroendocrine challenge, suggesting an altered stress response linked to migraine pathophysiology. #PainReports bit.ly/4kLyJyd

Jansen et al. present a case series of 10 patients with co-occurring cluster headache and short-lasting unilateral neuralgiform headache attacks, addressing clinical management, and exploring a potential shared pathophysiological link #PainReports bit.ly/4mAN3uT

Laughey et al. argue that bridging the gender pain gap requires collaborative efforts that address female-specific biological and psychosocial dimensions of pain through evidence-based, compassionate and empathy-driven approaches. Learn more in #PainReports bit.ly/3HiRaMb

Li et al. find that sleep medication use is common among veterans with chronic pain. Insomnia, psychiatric comorbidities, and current or recent opioid therapy are associated with a higher likelihood of sleep medication use. Learn more in #PainReports bit.ly/4jvDnzf

Ablin et al. argue that fibromyalgia, influenced by genetic and environmental factors, requires a multidisciplinary approach. Advances in genetics, microbiome research, and AI promise improved diagnosis and treatment. Learn more in #PainReports bit.ly/43igtqf

Temmermand et al. explore how epigenetic mechanisms contribute to chronic pain disparities among racial/ethnic groups, highlighting biopsychosocial factors that influence the pain experience. Learn more in #PainReports bit.ly/43hxlNQ

Shao et al. find that facial grimacing in mice is more pronounced when cutaneous and visceral tissues are injured during laparotomy surgery compared to cutaneous injury alone. Learn more in #PainReports bit.ly/4kyDQ4G

Bui et al. find that approximately 1 in 6 opioid-naïve patients who survived 12 months after first hip fracture surgery were persistent opioid users at 12 months posthospital discharge. Learn more in #PainReports bit.ly/4jopD9u

Nikolis et al. find that patients with higher baseline depression and anxiety (emotional distress) report less reductions in neck and back pain intensity after radiofrequency ablation. Learn more in #PainReports bit.ly/43lSHcU

Hooten et al. find that considerable differences exist in the effects of buprenorphine on pain perception in healthy adults related to the route of administration, dose, and stimulus modality. Learn more in #PainReports bit.ly/3T2XZ6Y

Madden et al. find that opioid prescribing patterns, combined with complementary medicine and outpatient services, significantly influence pain severity reporting among patients with opioid use and other substance use disorders. Learn more in #PainReports bit.ly/4kE3Qvp

Navasardyan et al. find that adolescents’ recall of back pain is influenced by current pain experiences, environmental sensitivity, and familial factors, emphasizing the complexity of assessing long-term pain histories. Learn more in #PainReports bit.ly/43PO6Ql

Smith et al. find that cumulative adverse childhood experience exposure is associated with multisite pain in early adolescence using data from the Adolescent Brain Cognitive Development Study. Learn more in #PainReports bit.ly/4jmLYnX

Vincenot et al. argue that the way pain has been perceived, understood, and treated has changed greatly over the centuries, from a divine punishment to a fully-fledged entity. Learn more in #PainReports bit.ly/4jrFfJc

The #PainReports June 2025 issue includes the final articles in our series on Epigenetic Regulation of Chronic Pain and Fibromyalgia. Read the entire issue for free at bit.ly/3HglTcC

Meller et al. find that neuropathic pain and small fiber impairment are common in neurofibromatosis, impairing quality of life. Accurate categorization and treatment are crucial for effective pain management. Learn more in #PainReports bit.ly/4jtnb1f

Smith et al. find that central aspects of pain link pain with physical inactivity and may pose a barrier to maintaining physical activity. Learn more in #PainReports bit.ly/43PPEK6

The June 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/3HglTcC

Tao et al. identified novel genes for neck or shoulder pain using new a definition in the UK Biobank dataset and replicated in the FinnGen dataset. Learn more in #PainReports bit.ly/4mEaxQ0

The #PainReports June 2025 issue includes the final articles in our series on Epigenetic Regulation of Chronic Pain and Fibromyalgia. Read the entire issue for free at bit.ly/3HglTcC

In older adults with low back pain, Kahan et al. find that laboratory and daily movement-evoked pain (MEP) were strongly correlated; psychological and immunological factors explained variance in both MEP outcomes. Learn more in #PainReports bit.ly/3Fns0vj

Verwoerd et al. studied differences in daily activities, patient concerns, and self-efficacy between first-episode and recurrent nonspecific neck pain patients. Learn more in #PainReports bit.ly/4mDijcS

The June 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/3HglTcC

Ali et al. identified 31 digital pain manikins, out of which only a few progressed to be used as a pain self-reporting tool. Learn more in #PainReports bit.ly/4jAwooU

The #PainReports June 2025 issue includes the final articles in our series on Epigenetic Regulation of Chronic Pain and Fibromyalgia. Read the entire issue for free at bit.ly/3HglTcC

For people with an acute episode of low back pain, Chang et al. find that processing of non-noxious sensory inputs changed over time differentiated 6-month pain, but not disability outcome. Learn more in #PainReports bit.ly/3FoaRld

Kumar et al. find that patients with migraine without aura exhibit heightened cortisol responses and gene expression changes after a neuroendocrine challenge, suggesting an altered stress response linked to migraine pathophysiology. #PainReports bit.ly/4kLyJyd