Sang Woo (Daniel) Park and I are excited to share a new preprint, "Susceptible host dynamics explain pathogen resilience to perturbations" [1/8] www.biorxiv.org/content/10.1...

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

Artigo liderado por @portellatp.bsky.social www.sciencedirect.com/science/arti...

Seems population immunity should be useful for forecasting flu, right? Using cross-sectional, age-representative neutralizing titers measured in the summer of 2017 in Philly, we find that the clade to which we infer the greatest susceptibility dominated the next season. Even more, we found...

Antibodies are the product of evolution on two timescales: over millions of years in vertebrate populations, and within weeks of infection or vaccination in populations of B cells. We ask how those timescales interact in our paper out in Plos Pathogens 🧵 1/n t.co/vRdGYYQwsU