Lucas Graybuck
@lucasgraybuck.bsky.social
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Assistant Investigator at the Allen Institute for Immunology
@parse.bsky.social
released an amazing 10M cell dataset for immunologists: they profiled 90 cytokine responses in 12 donors with the GigaLab platform:
www.parsebiosciences.com/datasets/10-...
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10 Million Human PBMCs in a Single Experiment - Parse Biosciences
https://www.parsebiosciences.com/datasets/10-million-human-pbmcs-in-a-single-experiment/?utm_campaign=7576393-GigaLab&utm_source=Allen%20Institute%20for%20Immunology%2010M&utm_medium=Web%20App
19 days ago
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reposted by
Lucas Graybuck
about 1 month ago
We have recently uploaded our revised manuscript “Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance”. TL;DR: More models, more tasks => same results.
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Looking forward to Cytokines 2025!
@alleninstitute.org
will be there, with posters about plasma cells, Rheumatoid arthritis, neuroimmune signaling, ulcerative colitis, TRM formation, and a new interferon signaling atlas. Times and details at:
apps.allenimmunology.org/aifi/present...
#cytokines2025
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Cytokines 2025
https://apps.allenimmunology.org/aifi/presentations/cytokines-2025/
about 1 month ago
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As we continue to develop the
@alleninstitute.org
Allen Institute for Immunology web platform, our first big challenge was to build tools to support the release of the amazing longitudinal Immune Health study, published yesterday in Nature:
www.nature.com/articles/s41...
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Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
https://www.nature.com/articles/s41586-025-09686-5
about 1 month ago
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reposted by
Lucas Graybuck
Allen Institute
3 months ago
Years before the pain begins, early-warning signs for rheumatoid arthritis (RA) could help doctors catch the disease before it starts. 🧵
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Two
#AACR25
posters from Allen Institute for Immunology will be up Tuesday from 9-12. Medbh Dillon will showcase 3D Multiple Myeloma culture models at Sec. 6, No. 14 Imran McGrath and I have our scRNA-seq and spatial transcriptomics from MM patients at Sec. 28 No. 11
@alleninstitute.bsky.social
7 months ago
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The Allen Institute for Immunology is at
#AACR25
conference! Come see my poster to preview our open data and tools for Multiple Myeloma. 2 PM, Section 46, Board 11 More details and where to find us at
tinyurl.com/allen-aacr-2...
@alleninstitute.bsky.social
@theaacr.bsky.social
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AACR 2025
https://tinyurl.com/allen-aacr-2025
8 months ago
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reposted by
Lucas Graybuck
Allen Institute
11 months ago
🩸🔬 Introducing
#CryoSCAPE
, a groundbreaking technique that keeps blood cells alive in deep freeze. This innovation promises to expand the reach of cutting-edge single-cell technologies to rural or underserved populations. ✨ 🧵
#SingleCellTech
#RNAseq
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Amazing new tools for targeting the striatum across species, from mouse to primate from my colleagues in Brain Science at the
@alleninstitute.bsky.social
.
www.biorxiv.org/content/10.1...
about 1 year ago
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As part of our Human Immune Health Atlas release from the Allen Institute for Immunology, we built a UMAP viewer for interactive data exploration that can handle millions of cells. You can find our Human Immune Health Atlas UMAP Explorer here:
apps.allenimmunology.org/aifi/resourc...
about 1 year ago
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The Data-Driven Discovery: AI and Modeling in Biology Workshop is happening now at the Allen Institute. I saw some great talks yesterday! More info below, with links to recordings and the live stream, can be found here:
#openscience
#machinelearning
#modeling
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Data-Driven Discovery: AI and Modeling in Biology Workshop
We are delighted to host you at the, “Data-Driven Discovery: AI and Modeling in Biology”. The workshop is hosted by the new Center for...
https://alleninstitute.org/events/data-driven-discovery-ai-and-modeling-in-biology/
about 1 year ago
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reposted by
Lucas Graybuck
Allen Institute
about 1 year ago
To understand disease, we must understand the healthy immune system, deeply and across the human lifespan. Thanks to the dedication of ~100 healthy volunteers and many research teams, we are proud to share the Human Immune Health Atlas. 🧵
#OpenScienceWeek
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