Dave Weisman
@dweisman.bsky.social
📤 606
📥 549
📝 479
Neurologist, trialist, focused on Alzheimer’s disease. Skeptical doesn’t mean cynical.
Wrapping up Vermont riding.
5 days ago
1
3
0
Another mouseheimer's paper blown up beyond all reason. Please, do not take Lithium for memory or Alzheimer's disease.
wapo.st/47uJMrU
loading . . .
How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s
A new study suggests lithium may play a crucial role in developing Alzheimer’s treatments, but the substance has long been used to treat mood disorders like bipolar disorder.
https://wapo.st/47uJMrU
about 2 months ago
0
1
0
Check this conversation out on Neurology Live.
www.neurologylive.com/peers-perspe...
loading . . .
Approaches and Considerations in Mild Cognitive Impairment Due to Alzheimer
Experts discuss the importance of early diagnosis in Alzheimer disease, and discuss the safety and efficacy of newer treatment options for mild cognitive impairment.
https://www.neurologylive.com/peers-perspectives/approaches-and-considerations-in-mild-cognitive-impairment-due-to-alzheimer
2 months ago
0
0
0
The basis of informed consent is falsifying medical records?
3 months ago
0
0
0
How to implement anti-amyloid therapies lecanemab or donanemab:
practicalneurology.com/diseases-dia...
loading . . .
Building an Infrastructure to Administer Amyloid-Targeting Treatments
With the introduction of amyloid-targeting therapies, clinicians face a paradigm shift, requiring new clinical systems, interdisciplinary teams, and exper…
https://practicalneurology.com/diseases-diagnoses/alzheimer-disease-dementias/building-an-infrastructure-to-administer-amyloid-targeting-treatments/36187/
3 months ago
0
1
1
New titration of donanemab is approved. Not aware of anyone who use the previous titration, but good to see this.
www.biospace.com/policy/lilly...
loading . . .
Lilly Gets FDA Label Update for Alzheimer’s Drug To Mitigate Safety Concerns
The FDA will allow a new dosing schedule for Eli Lilly’s Alzheimer’s drug Kisunla that could lessen a known side effect of the monoclonal antibody drug class that has led to several deaths.
https://www.biospace.com/policy/lilly-gets-fda-label-update-for-alzheimers-drug-to-mitigate-safety-concerns?trk=feed_main-feed-card_feed-article-content
3 months ago
0
5
2
This entire Sage story added nothing to patient care or to the economy. Just wasted efforts to rearrange the deck chairs. Then set all the staff adrift.
www.biospace.com/business/sag...
loading . . .
Sage’s Search for Lifeline Ran Into Defiant Biogen CEO
After the FDA rejection of Zurzuvae in one type of depression and the triple failure of neuro asset dalzanemdor, Sage was searching for a path forward at the end of December 2024. Biogen CEO Chris Vie...
https://www.biospace.com/business/sages-search-for-lifeline-ran-into-defiant-biogen-ceo
3 months ago
0
1
0
I did a thing for Medscape. Very good patient-physician interactions, and the structure and thinking behind those conversations.
www.medscape.org/sites/pwr/ad...
loading . . .
Life in the Dementia Clinic: Contextualizing Treatment Options for Early Stages of Alzheimer's Disease
Unlock Better Conversations: Guiding Patients Through Benefits and Risks of Anti-Amyloid Alzheimer's Therapy
https://www.medscape.org/sites/pwr/ad-treatment-conversations
3 months ago
0
0
0
How many humans will die as a result of this? Pathogens don't respect borders.
www.nytimes.com/2025/06/25/h...
loading . . .
Kennedy Withdraws Funding Pledge to International Vaccine Agency
https://www.nytimes.com/2025/06/25/health/kennedy-vaccines-gavi.html
3 months ago
0
1
2
Can the UK legislate itself to biotech greatness? At least they're trying.
www.fiercepharma.com/pharma/uk-la...
loading . . .
UK lays out strategy to become a top 3 life sciences economy by 2035
With a goal of boosting its life sciences economy into the top three of the global rankings by 2035, the U.K. | With a goal of boosting its life sciences economy into the top three of the global ranki...
https://www.fiercepharma.com/pharma/uk-lays-out-strategy-playbook-becoming-top-3-life-sciences-economy-2035
3 months ago
0
0
0
Incrementalism works. This is great news.
www.nytimes.com/2025/06/03/h...
loading . . .
From No Hope to a Potential Cure for a Deadly Blood Cancer
https://www.nytimes.com/2025/06/03/health/multiple-myeloma-car-t-immunotherapy.html?smid=bs-share
4 months ago
0
1
0
This comes up all the time. Great idea, I hope this is implemented widely.
add a skeleton here at some point
4 months ago
0
4
0
"Unless these journals change dramatically, we are going to stop NIH scientists from publishing there, and we're going to create our own journals... They're going to become the pre-eminent journals, because if you get NIH funding, it is anointing you as a good, legitimate scientist." -K Jr. What?
4 months ago
0
0
0
Excellent takedown of an Alzheimer’s quack. My only critique of the piece is that we need more photos of that cat. Great job
@nytimes.com
- almost making up for the APOE article.
www.nytimes.com/2025/05/21/w...
loading . . .
An Expensive Alzheimer’s Lifestyle Plan Offers False Hope, Experts Say
https://www.nytimes.com/2025/05/21/well/alzheimer-symptoms-reversal-dale-bredesen.html?smid=bs-share
4 months ago
0
0
0
A pediatrician at Feinberg Northwestern just denied an amyloid PET scan on the phone with me. Does this world even make sense anymore?
4 months ago
0
0
0
The Wash U lecanemab paper is a hard act to follow. But here’s a combo experience with a private clinic and U Wash.
link.springer.com/article/10.1...
loading . . .
Monoclonal antibody administration in an academic institution and private neurological practice: a tale of two clinics - Journal of Neurology
The emergence of monoclonal antibody (MABs) drugs since the FDA approval of lecanemab has resulted in dramatic changes in the clinical approach and management of early-stage Alzheimer’s disease (AD). ...
https://link.springer.com/article/10.1007/s00415-025-13142-9#citeas
5 months ago
0
3
1
Probably the best data since lecanamab RCT and OLE on patient safety.
@suzanneeschindler.bsky.social
et al did RCT level trial work on every patient getting leqembi with HUGE n, kept things boring, with many lessons learned here.
jamanetwork.com/journals/jam...
loading . . .
Lecanemab Treatment in a Specialty Memory Clinic
This study examines the feasibility and safety of treating patients in specialty memory clinics with lecanemab.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2833457
5 months ago
1
4
0
The slow twitch muscles let me down. But I’m proud of this epic ride.
strava.app.link/z8ZsTQqi6Sb
loading . . .
https://strava.app.link/z8ZsTQqi6Sb
5 months ago
1
0
0
I’m up in the mountains of Denver. Trails going up need oxygen.
5 months ago
1
2
0
WIth 94 sequential patients on lecanemab, what did we learn?
www.vumedi.com/video/real-w...
loading . . .
Real-World Experience With Long-Term Lecanemab Treatment: A Retrospective Chart Review in Early Alzheimer's Disease
A video from David Weisman, posted on Apr 17, 2025.
https://www.vumedi.com/video/real-world-experience-with-long-term-lecanemab-treatment-a-retrospective-chart-review-in-early-alzhe/
5 months ago
1
3
2
New point when doing insurance “peer to peers.”
add a skeleton here at some point
5 months ago
0
1
0
The poisons we should worry about more than sugar.
www.washingtonpost.com/nation/2025/...
loading . . .
USDA rolls back plans to limit salmonella levels in raw chicken, turkey
The agency said the Biden-era proposal would have been a burden on businesses. Food-safety experts criticized the decision as an unwillingness to protect the public.
https://www.washingtonpost.com/nation/2025/04/25/usda-chicken-salmonella-trump-agriculture/
5 months ago
0
1
0
Amazing work. Dissociate amyloid from tau, could be huge effect.
add a skeleton here at some point
5 months ago
0
1
0
Check this out, two learned doctors talking anti-amyloid therapies, lecanemab and donanemab, some lessons learned, hopefully some nuggets of wisdom.
www.neurologylive.com/peers-perspe...
loading . . .
Approaches and Considerations in Mild Cognitive Impairment Due to Alzheimer
Experts discuss the importance of early diagnosis in Alzheimer disease, and discuss the safety and efficacy of newer treatment options for mild cognitive impairment.
https://www.neurologylive.com/peers-perspectives/approaches-and-considerations-in-mild-cognitive-impairment-due-to-alzheimer
5 months ago
0
2
0
Tell it to the face of a kid with cystic fibrosis, “you are not patriotic.”
www.latintimes.com/dr-oz-ridicu...
loading . . .
Dr Oz Ridiculed for Advising Americans to Use Less Drugs to Reduce Drug Spending: 'Tell That to a Diabetic'
As Dr. Mehmet Oz was sworn in as head of Medicare and Medicaid, he encouraged Americans to reduce drug spending by simply staying healthy.
https://www.latintimes.com/dr-oz-ridiculed-advising-americans-use-less-drugs-reduce-drug-spending-tell-that-diabetic-581196
5 months ago
0
5
3
IBX will not cover lecanemab unless the person has Medicare? So people with early Alzheimer's, the same disease, suffer age discrimination. How is this legal?
5 months ago
0
1
0
I was expecting this question to be answered in the negative. Is my brain broken by expecting internet contrarians?
www.sciencedirect.com/science/arti...
loading . . .
Are Appropriate Use Recommendations useful in clinical practice?
https://www.sciencedirect.com/science/article/pii/S2274580725001104#bib0003
5 months ago
0
1
0
Makary recently learned industry employed experts sit on ad coms, so perhaps he doesn't know they are non-voting members? Dismissing insight and expertise is never wise.
www.statnews.com/2025/04/17/f...
via
@statnews.com
loading . . .
Makary says FDA will remove pharma representatives from advisory panels
Representatives from pharma and other industries already play a more limited role in advising the FDA.
https://www.statnews.com/2025/04/17/fda-advisory-panels-pharma-industry-employees-patients-caregivers/
5 months ago
0
0
0
Great thread on ARIA. Thanks!
add a skeleton here at some point
5 months ago
1
1
0
Patient, "I called the guy on call last week, wow, he sounded stressed out. I said, 'hey, don't worry about me, I'll call back later.'" It is so weird and rare to have compassion flowing from patients towards doctors.
6 months ago
0
2
0
Great news today. Lecanemab approved in Europe. I quibble with the fact that genetic discrimination is permitted, but this probably won’t last long.
add a skeleton here at some point
6 months ago
2
6
3
reposted by
Dave Weisman
Nicolas Villain
6 months ago
Oh! It was finally approved today! 🍾🍾
ec.europa.eu/newsroom/san...
loading . . .
HEALTH AND FOOD SAFETY - Commission authorises medicine for treatment of early Alzheimer’s disease
https://ec.europa.eu/newsroom/sante/items/879055/en
0
6
3
‘The Pitt’ does capture the overcrowding, but the ER docs do not use resources wisely, handingly palliative care and brain death instead of calling for consults. I'm only 3 episodes in though. Does it get better?
www.nytimes.com/2025/04/10/h...
loading . . .
‘The Pitt’ Captures the Real Overcrowding Crisis in Emergency Rooms
From the “chairs” to the hallway medicine, the show’s depiction of an emergency medicine system that is beyond capacity rings true for medical experts.
https://www.nytimes.com/2025/04/10/health/the-pitt-max-crowded-emergency-rooms.html?smid=bs-share
6 months ago
0
0
0
Not a man of action. More of an idea man. Not good ideas, but they are ideas.
add a skeleton here at some point
6 months ago
0
2
0
Asians may not have as much ARIA. Really no clue why but I’m open to ideas. Limitations are present, but if this is seen in donanemab, would be more signal than noise.
6 months ago
1
1
0
He does the same in hallways!
@renegadesynapse.bsky.social
great bumping into you.
add a skeleton here at some point
6 months ago
1
2
0
reposted by
Dave Weisman
Stacey L. Clardy
6 months ago
Dr. Trey Bateman
@renegadesynapse.bsky.social
of Wake Forest University School of Medicine giving a fast-paced, info-packed “Updates in Cognitive and Behavioral Neurology” at C10: Neurology Update at the
@aanmember.bsky.social
Annual Meeting.
#AANAM
0
13
6
Big loss today. Alzheon overall trial was negative. But there were provocative findings.
www.neurologylive.com/view/valiltr...
loading . . .
Valiltramiprosate Demonstrates Greater Promise in Milder Forms of Alzheimer Disease, Phase 3 APOLLOE4 Study Shows
Although valiltramiprosate failed to distinguish itself from placebo on the primary end point, the drug performed significantly better among mild MCI participants vs those with mild Alzheimer disease.
https://www.neurologylive.com/view/valiltramiprosate-demonstrates-greater-promise-milder-forms-alzheimer-disease-phase-3-apolloe4-study-shows
6 months ago
1
3
1
Sigh. Another day, another bad faith (bleed/lede!) news piece about the anti-amyloid drugs.
6 months ago
1
0
0
Fraud, arrogance, and tragedy: the case of Doctored - The Lancet Neurology
www.thelancet.com/journals/lan...
loading . . .
Fraud, arrogance, and tragedy: the case of Doctored
Over the past few months, investigative journalist Charles Piller has published—eg, in The Daily Mail, The New York Times, and Science—multiple reports of supposed historical fraud in Alzheimer's dise...
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2825%2900112-7/fulltext
6 months ago
1
4
1
Fantastic essay on AI, which is turning to out to be a not revolutionary technology. “A.I. is a parasite.” This isn’t mutualism.
www.nytimes.com/2025/03/29/o...
loading . . .
Opinion | The Tech Fantasy That Powers A.I. Is Running on Fumes
A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.
https://www.nytimes.com/2025/03/29/opinion/ai-tech-innovation.html?smid=bs-share
6 months ago
0
1
0
Wasn’t this the initial impression for lecanemab as well?
firstwordpharma.com/story/5945673
loading . . .
FirstWord
https://firstwordpharma.com/story/5945673
6 months ago
0
0
0
The ducks are back at Wiss. Good news, more riding.
6 months ago
0
0
0
Imagine how bad it would have been if we had elected that email lady.
www.nytimes.com/live/2025/03...
loading . . .
Trump Live Updates: Hegseth's War Plan Texts, Tariffs and Federal Layoffs
https://www.nytimes.com/live/2025/03/24/us/trump-news?smid=bs-share
6 months ago
0
0
1
Top 5 for March Madness in the office and, as a bad high school wrestler, know nothing about basketball. Next year Vegas.
6 months ago
0
0
0
Twenty years ago, March 21, 2005, W Bush flew to Washington, D.C. from vacation to transfer jurisdiction of the Schiavo case to the federal courts to delay comfort care. We’ve had meddling fools in office before, which should offer some hope.
6 months ago
0
1
0
Perfect summation.
wapo.st/41ICahj
loading . . .
Opinion | RFK Jr. is spewing childish libertarian nonsense
Vaccines are not a “personal choice.” We give up some personal freedoms so we all stay alive.
https://wapo.st/41ICahj
6 months ago
0
5
1
At this point beating up on Piller seems beside the point, but his book poisons the discourse. This response says it all. Kudos to Grill and Rabinovici.
jamanetwork.com/journals/jam...
loading . . .
The Bad Medicine of Doctored
This Viewpoint discusses a recent book that alleges scientific misconduct in Alzheimer disease (AD) research; summarizes actual progress made in the field; suggests that the book contributes to a narr...
https://jamanetwork.com/journals/jama/fullarticle/2831830
6 months ago
2
5
2
Mehmet Oz: "exercise decreases the amount of Apo E4 in the blood." What if one is APOE44! The next leader of CMS!
www.oprah.com/health/dr-oz...
loading . . .
15 Ways to Remember <i>Anything</i>, from Dr. Oz
Fifteen ways to sharpen your mind, strengthen your brain, and keep your thoughts in order.
https://www.oprah.com/health/dr-ozs-memory-enhancing-tricks/all#ixzz6G8FJX1hx
6 months ago
0
1
0
How about hair and skin dyes? Or are those sacrosanct?
fortune.com/well/2025/03...
loading . . .
RFK Jr. gives food companies ultimatum to remove artificial dyes
Health advocates have said for years that synthetic colors add no taste or nutritional value but make unhealthy foods more visually appealing.
https://fortune.com/well/2025/03/11/rfk-food-kraft-heinz-general-mills-dye-food-babe-toxins-hyperactivity-children/
7 months ago
0
1
0
Load more
feeds!
log in
