Imad Damaj
@damajlab.bsky.social
📤 83
📥 106
📝 29
Neuropharmacology of pain and addiction VCU
www.genengnews.com/topics/trans...
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Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
https://www.genengnews.com/topics/translational-medicine/why-we-still-need-animal-research-in-a-world-of-ai-and-organoids/
3 months ago
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Just out in @TheJournal_Pain: “Paclitaxel-Induced Neuroinflammation After Systemic Administration in Male and Female Mice” Paclitaxel-induced increase in neuroinflammation is time-, sex-, and tissue- dependent.
www.jpain.org/article/S152...
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Paclitaxel-Induced Neuroinflammation After Systemic Administration in Male and Female Mice
Peripheral neuropathy is one of the most prevalent neurotoxic, dose-limiting side effects of paclitaxel, a chemotherapy agent used widely in solid cancers. The mechanism of paclitaxel-induced peripher...
https://www.jpain.org/article/S1526-5900(25)00737-0/abstract
3 months ago
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Check out our newest paper with the talented former Ph.D. Student Bryan McKiver! Astrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy.
www.sciencedirect.com/science/arti...
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Astrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy treatment, often resulting in the discontinuation of …
https://www.sciencedirect.com/science/article/abs/pii/S0889159125001059
7 months ago
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Just out: Our paper in collaboration with Javier Gonzalez-Maeso group demonstrating the long lasting effects of a single dose of psilocybin in mouse models of chronic pain.
@jgmaeso.bsky.social
www.sciencedirect.com/science/arti...
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IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain
Chronic pain is a debilitating disease with current treatments lacking efficacy and safety, therefore discovery of new treatments is crucial. Initial …
https://www.sciencedirect.com/science/article/pii/S1043661825001240
7 months ago
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reposted by
Imad Damaj
eLife
7 months ago
Research is investigating the medicinal applications of
#psilocybin
, with studies showing how
#psychedelics
can promote neuronal plasticity. This ‘fundamental’ study into the effects of
#psilocin
on human neurons:
buff.ly/f7cNemV
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I was happy to be part of this interesting study with
@jgmaeso.bsky.social
and his team! “Upregulation of the neuropeptide receptor calcitonin receptor-like in the spinal cord via MLL2 in a mouse model of paclitaxel-induced peripheral neuropathy”
journals.sagepub.com/doi/10.1177/...
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Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
https://journals.sagepub.com/doi/10.1177/17448069251314857?trk=feed-detail_main-feed-card_feed-article-content
8 months ago
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Glad to have been part of this interesting project!
pubs.acs.org/doi/10.1021/...
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New PPARα Agonist A190-Loaded Microemulsion for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of anticancer agents with limited effective preventive or therapeutic interventions. Although fenofibrate, a peroxisome proli...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c01374
9 months ago
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Join us for this interesting virtual conference!
9 months ago
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Still working on nicotinic receptors and pain !
pubmed.ncbi.nlm.nih.gov/39829331/
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Sulfonium Moieties as Ammonium Bioisosteres: Novel Ligands for the Alpha7 Nicotinic Acetylcholine Receptor - PubMed
In the pressing quest of novel treatments for chronic pain, α7 nAChR silent agonists show efficacy as anti-inflammatory modulators and represent a promising strategy. Recent findings reveal that a sul...
https://pubmed.ncbi.nlm.nih.gov/39829331/
9 months ago
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What a circus!!!
www.science.org/content/arti...
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Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
https://www.science.org/content/article/trump-hits-nih-devastating-freezes-meetings-travel-communications-and-hiring
9 months ago
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